Tyck till om SwePub Sök
här!
Search: L773:0197 4580 OR L773:1558 1497 >
Age-correlated loss...
Age-correlated loss of dopamine uptake sites labeled with [3H]GBR-12935 in human putamen.
-
- Allard, Per (author)
- Umeå universitet,Psykiatri
-
Marcusson, J O (author)
-
(creator_code:org_t)
- 1989
- 1989
- English.
-
In: Neurobiology of Aging. - 0197-4580 .- 1558-1497. ; 10:6, s. 661-4
- Related links:
-
https://urn.kb.se/re...
Abstract
Subject headings
Close
- The effects of age (19-100 years) upon dopamine uptake sites labeled with [3H]GBR-12935 in human postmortem putamen from 20 individuals were studied. There was a 70% decrease in binding density (Bmax) over the adult age range. No significant changes in binding affinity (Kd) were detected, the mean Kd being 1.0 +/- 0.2 nM (mean +/- S.E.M.). Nor were there any changes in binding related to the postmortem delay. Based on the findings that [3H]GBR-12935 labels the uptake site for dopamine, it is suggested that the age-related loss of [3H]GBR-12935 binding in human putamen reflects a degeneration of dopamine neurites.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database