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Biological characte...
Biological characteristics of adrenocortical carcinoma : A study of p53, IGF, EGF-r, Ki-67 and PCNA in 17 adrenocortical carcinomas
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Edgren, M (författare)
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- Eriksson, Barbro (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrin tumörbiologi
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- Wilander, Erik (författare)
- Uppsala universitet,Molekylär och morfologisk patologi
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visa fler...
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Westlin, J-E (författare)
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- Nilsson, Sven (författare)
- Uppsala universitet,Enheten för radiologi
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- Öberg, Kjell (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi
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visa färre...
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(creator_code:org_t)
- 1997
- 1997
- Engelska.
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 17:2B, s. 1303-1310
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Adrenocortical carcinoma (ACC) is a rare neoplasm with a poor prognosis. Prognostic factors are needed to identify patients who should be treated aggressively and those for which a less aggressive approach is warranted. As a result of advances within the field of immunohistochemistry, investigations of Ki-67, PCNA, IGF, EGF-r and p53 were performed in 17 ACC. The aim of this study was to clarify the role of Ki-67, PCNA, EGF-r, IGF and p53 in correlation to tumour behaviour and outcome. This retrospective study includes 16 patients, 10 women and 6 men, with a median age of 46 years. Nine tumours were hormonally functioning and 7 were non-functioning. The results obtained revealed that all tumours expressed PCNA and Ki-67 with median values of 59% and 14%, respectively, while p53 was negative in 88%, IGF negative in 82% and EGF-r positive in 94% of the tumours. No correlation was found between p53, IGF, EGF-r and survival rate. There was no interdependence between PCNA and Ki-67, or between PCNA, Ki-67 and the survival rate.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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