Estramustine a radio sensitising agent.

• The present study revealed that estramustine acts as a radio sensitising agent on the human renal cell cancer cell lines, A498 and CAKI-2. In vitro experiments used the Bürker chamber technique. Both cell lines were markedly resistant to external beam irradiation. While pretreatment of the cell cultures with estramustine prior to external beam irradiation revealed an arrest of cell growth in both cell lines. The results of this study suggest that estramustine could be utilised as a radiosensitizing agent. This in turn could open a new method for the management of patients with advanced renal cell carcinoma (RCC).

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Antineoplastic Agents

pharmacology

Carcinoma

Renal Cell

pathology

radiotherapy

Estramustine

pharmacology

Humans

Kidney Neoplasms

pathology

radiotherapy

Radiation-Sensitizing Agents

pharmacology

Tumor Cells

Cultured

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)