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Sökning: onr:"swepub:oai:DiVA.org:uu-481275" > Growth hormone secr...

Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice

Aguggia, Julieta P. (författare)
Natl Univ La Plata, Argentine Res Council CONICET, Multidisciplinary Inst Cell Biol IMBICE, Lab Neurophysiol, La Plata, Buenos Aires, Argentina.;Natl Univ La Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina.
Cornejo, Maria P. (författare)
Natl Univ La Plata, Argentine Res Council CONICET, Multidisciplinary Inst Cell Biol IMBICE, Lab Neurophysiol, La Plata, Buenos Aires, Argentina.;Natl Univ La Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina.
Fernandez, Gimena (författare)
Natl Univ La Plata, Argentine Res Council CONICET, Multidisciplinary Inst Cell Biol IMBICE, Lab Neurophysiol, La Plata, Buenos Aires, Argentina.;Natl Univ La Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina.
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De Francesco, Pablo N. (författare)
Natl Univ La Plata, Argentine Res Council CONICET, Multidisciplinary Inst Cell Biol IMBICE, Lab Neurophysiol, La Plata, Buenos Aires, Argentina.;Natl Univ La Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina.
Mani, Bharath K. (författare)
UT Southwestern Med Ctr, Ctr Hypothalam Res, Dept Internal Med, Dallas, TX USA.
Cassano, Daniela (författare)
Natl Univ La Plata, Argentine Res Council CONICET, Multidisciplinary Inst Cell Biol IMBICE, Lab Neurophysiol, La Plata, Buenos Aires, Argentina.;Natl Univ La Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina.
Cabral, Agustina (författare)
Natl Univ La Plata, Argentine Res Council CONICET, Multidisciplinary Inst Cell Biol IMBICE, Lab Neurophysiol, La Plata, Buenos Aires, Argentina.;Natl Univ La Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina.
Valdivia, Spring (författare)
Natl Univ La Plata, Argentine Res Council CONICET, Multidisciplinary Inst Cell Biol IMBICE, Lab Neurophysiol, La Plata, Buenos Aires, Argentina.;Natl Univ La Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina.
Garcia Romero, Guadalupe (författare)
Natl Univ La Plata, Argentine Res Council CONICET, Multidisciplinary Inst Cell Biol IMBICE, Lab Neurophysiol, La Plata, Buenos Aires, Argentina.;Natl Univ La Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina.
Reynaldo, Mirta (författare)
Natl Univ La Plata, Argentine Res Council CONICET, Multidisciplinary Inst Cell Biol IMBICE, Lab Neurophysiol, La Plata, Buenos Aires, Argentina.;Natl Univ La Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina.
Fehrentz, Jean-Alain (författare)
Univ Montpellier, Fac Pharm, Inst Biomol Max Mousseron, UMR 5247 CNRS,ENSCM, Montpellier, France.
Zigman, Jeffrey M. (författare)
UT Southwestern Med Ctr, Ctr Hypothalam Res, Dept Internal Med, Dallas, TX USA.
Perello, Mario (författare)
Uppsala universitet,Funktionell farmakologi och neurovetenskap,Natl Univ La Plata, Argentine Res Council CONICET, Multidisciplinary Inst Cell Biol IMBICE, Lab Neurophysiol, La Plata, Buenos Aires, Argentina.;Natl Univ La Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina.
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Natl Univ La Plata, Argentine Res Council CONICET, Multidisciplinary Inst Cell Biol IMBICE, Lab Neurophysiol, La Plata, Buenos Aires, Argentina;Natl Univ La Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, La Plata, Buenos Aires, Argentina. UT Southwestern Med Ctr, Ctr Hypothalam Res, Dept Internal Med, Dallas, TX USA. (creator_code:org_t)
Elsevier, 2022
2022
Engelska.
Ingår i: Psychoneuroendocrinology. - : Elsevier. - 0306-4530 .- 1873-3360. ; 139
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Ghrelin is a stomach-derived hormone that acts via the growth hormone secretagogue receptor (GHSR). Recent evidence suggests that some of ghrelin's actions may be mediated via the supramammillary nucleus (SuM). Not only does ghrelin bind to cells within the mouse SuM, but ghrelin also activates SuM cells and intra-SuM ghrelin administration induces feeding in rats. In the current study, we aimed to further characterize ghrelin action in the SuM. We first investigated a mouse model expressing enhanced green fluorescent protein (eGFP) under the promoter of GHSR (GHSR-eGFP mice). We found that the SuM of GHSR-eGFP mice contains a significant amount of eGFP cells, some of which express neuronal nitric oxide synthase. Centrally-, but not systemically-, injected ghrelin reached the SuM, where it induced c-Fos expression. Furthermore, a 5-day 40% calorie restriction protocol, but not a 2-day fast, increased c-Fos expression in non-eGFP+ cells of the SuM of GHSR-eGFP mice, whereas c-Fos induction by calorie restriction was not observed in GHSR-deficient mice. Exposure of satiated mice to a binge-like eating protocol also increased c-Fos expression in non-eGFP+ cells of the SuM of GHSR-eGFP mice in a GHSR-dependent manner. Finally, intra-SuM-injected ghrelin did not acutely affect food intake, locomotor activity, behavioral arousal or spatial memory but increased recognition memory. Thus, we provide a compelling neuroanatomical characterization of GHSR SuM neurons and its behavioral implications in mice.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Ghrelin receptor
Hypothalamus
Reward
Behavior
Memory

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