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Neuronal Expression...
Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain
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- Bazov, Igor, 1973- (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Sarkisyan, Daniil (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Kononenko, Olga (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Watanabe, Hiroyuki (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Taqi, Malik Mumtaz, 1983- (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Faculty of Medicine, NORMENT, University of Oslo, Oslo, Norway,Uppsala University, Uppsala, Sweden; University of Oslo, Oslo, Norway
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- Stålhandske, Lada (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Verbeek, Dineke S (author)
- Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
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- Mulder, Jan (author)
- Karolinska Institutet,Department of Neuroscience, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden
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- Rajkowska, Grazyna (author)
- Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
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- Sheedy, Donna (author)
- Discipline of Pathology, Sydney Medical School, University of Sydney, Sydney NSW, Australia
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- Kril, Jillian (author)
- Discipline of Pathology, Sydney Medical School, University of Sydney, Sydney NSW, Australia
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- Sun, Xueguang (author)
- Zymo Research Corporation, 17062 Murphy Avenue, Irvine, CA, USA; Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
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- Syvänen, Ann-Christine, 1950- (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab,Uppsala University, Uppsala, Sweden
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- Yakovleva, Tatiana (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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- Bakalkin, Georgy (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2017-07-28
- 2018
- English.
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In: Cerebral Cortex. - : Oxford University Press (OUP). - 1047-3211 .- 1460-2199. ; 28:9, s. 3129-3142
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Abstract
Subject headings
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- Molecular mechanisms that define patterns of neuropeptide expression are essential for the formation and rewiring of neural circuits. The prodynorphin gene (PDYN) gives rise to dynorphin opioid peptides mediating depression and substance dependence. We here demonstrated that PDYN is expressed in neurons in human dorsolateral prefrontal cortex (dlPFC), and identified neuronal differentially methylated region in PDYN locus framed by CCCTC-binding factor binding sites. A short, nucleosome size human-specific promoter CpG island (CGI), a core of this region may serve as a regulatory module, which is hypomethylated in neurons, enriched in 5-hydroxymethylcytosine, and targeted by USF2, a methylation-sensitive E-box transcription factor (TF). USF2 activates PDYN transcription in model systems, and binds to nonmethylated CGI in dlPFC. USF2 and PDYN expression is correlated, and USF2 and PDYN proteins are co-localized in dlPFC. Segregation of activatory TF and repressive CGI methylation may ensure contrasting PDYN expression in neurons and glia in human brain.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- DNA methylation
- cell type-specific expression
- human brain
- neuropeptides
- transcription
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bazov, Igor, 197 ...
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Sarkisyan, Danii ...
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Kononenko, Olga
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Watanabe, Hiroyu ...
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Taqi, Malik Mumt ...
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Stålhandske, Lad ...
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show more...
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Verbeek, Dineke ...
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Mulder, Jan
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Rajkowska, Grazy ...
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Sheedy, Donna
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Kril, Jillian
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Sun, Xueguang
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Syvänen, Ann-Chr ...
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Yakovleva, Tatia ...
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Bakalkin, Georgy
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Cerebral Cortex
- By the university
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Uppsala University
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Örebro University
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Karolinska Institutet