Sökning: onr:"swepub:oai:gup.ub.gu.se/338374" >
Association between...
Association between overweight and obesity with coronary artery bypass graft failure: an individual patient data analysis of clinical trials.
-
An, Kevin R (författare)
-
Sandner, Sigrid (författare)
-
- Redfors, Björn (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
visa fler...
-
Alexander, John H (författare)
-
Alzghari, Talal (författare)
-
Caldonazo, Tulio (författare)
-
Cancelli, Gianmarco (författare)
-
Dell'Aquila, Michele (författare)
-
Dimagli, Arnaldo (författare)
-
Gibson, C Michael (författare)
-
Harik, Lamia (författare)
-
Heise, Rachel (författare)
-
Kulik, Alexander (författare)
-
Lamy, Andre (författare)
-
Leith, Jordan (författare)
-
Peper, Joyce (författare)
-
Perezgrovas-Olaria, Roberto (författare)
-
Rossi, Camilla S (författare)
-
Ruel, Marc (författare)
-
Soletti, Giovanni (författare)
-
Ten Berg, Jurrien M (författare)
-
Willemsen, Laura M (författare)
-
Wojdyla, Daniel M (författare)
-
Zhao, Qiang (författare)
-
Zhu, Yunpeng (författare)
-
Verma, Subodh (författare)
-
Gaudino, Mario F L (författare)
-
visa färre...
-
(creator_code:org_t)
- 2024
- 2024
- Engelska.
-
Ingår i: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. - 1873-734X.
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The association between obesity and graft failure after coronary artery bypass grafting has not been previously investigated.We pooled individual patient data from randomized clinical trials with systematic post-operative coronary imaging to evaluate the association between obesity and graft failure at the individual graft and patient levels. Penalized cubic regression splines and mixed-effects multivariable logistic regression models were performed.Six trials comprising 3,928 patients and 12,048 grafts were included. The median time to imaging was 1.03 (IQR, 1.00-1.09) years. By body mass index (BMI) category, 800 (20.4%) patients were normal weight (BMI 18.5-24.9), 1,668 (42.5%) were overweight (BMI 25-29.9), 983 (25.0%) were obesity class 1 (BMI 30-34.9), 344 (8.8%) were obesity class 2 (BMI 35-39.9), and 116 (2.9%) were obesity class 3 (BMI 40+). As a continuous variable, BMI was associated with reduced graft failure (adjusted odds ratio [aOR] 0.98 [95% CI, 0.97-0.99]) at the individual graft level. Compared to normal weight patients, graft failure at the individual graft level was reduced in overweight (aOR 0.79 [95% CI, 0.64-0.96]), obesity class 1 (aOR 0.81 [95% CI, 0.64-1.01]), and obesity class 2 (aOR 0.61 [95% CI, 0.45-0.83]) patients, but not different compared to obesity class 3 (aOR 0.94 [95% CI, 0.62-1.42]) patients. Findings were similar, but did not reach significance, at the patient level.In a pooled individual patient data analysis of randomized clinical trials, BMI and obesity appear to be associated with reduced graft failure at one year after coronary artery bypass grafting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
An, Kevin R
-
Sandner, Sigrid
-
Redfors, Björn
-
Alexander, John ...
-
Alzghari, Talal
-
Caldonazo, Tulio
-
visa fler...
-
Cancelli, Gianma ...
-
Dell'Aquila, Mic ...
-
Dimagli, Arnaldo
-
Gibson, C Michae ...
-
Harik, Lamia
-
Heise, Rachel
-
Kulik, Alexander
-
Lamy, Andre
-
Leith, Jordan
-
Peper, Joyce
-
Perezgrovas-Olar ...
-
Rossi, Camilla S
-
Ruel, Marc
-
Soletti, Giovann ...
-
Ten Berg, Jurrie ...
-
Willemsen, Laura ...
-
Wojdyla, Daniel ...
-
Zhao, Qiang
-
Zhu, Yunpeng
-
Verma, Subodh
-
Gaudino, Mario F ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
European journal ...
- Av lärosätet
-
Göteborgs universitet