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Disease burden and ...
Disease burden and unmet need for acute allergic reactions - A patient perspective
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- Andersson, Emelie (författare)
- Swedish Inst Hlth Econ IHE, Lund, Sweden.;Swedish Inst Hlth Econ, Rabygatan 2, S-22361 Lund, Sweden.,IHE – The Swedish Institute for Health Economics
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- Löfvendahl, Sofia (författare)
- Swedish Inst Hlth Econ IHE, Lund, Sweden.,IHE – The Swedish Institute for Health Economics
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- Olofsson, Sara (författare)
- Swedish Inst Hlth Econ IHE, Lund, Sweden.,IHE – The Swedish Institute for Health Economics
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- Wahlberg, Karin (författare)
- Swedish Inst Hlth Econ IHE, Lund, Sweden.,IHE – The Swedish Institute for Health Economics
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- Bjermer, Leif (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Respiratory Medicine,Lund University Research Groups,Lund Univ, Dept Resp Med & Allergol, Lund, Sweden.
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- Tornling, Göran (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med Solna, Resp Med Div, Stockholm, Sweden.
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- Janson, Christer (författare)
- Uppsala University,Uppsala universitet,Lung- allergi- och sömnforskning
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- Hjelmgren, Jonas (författare)
- Swedish Inst Hlth Econ IHE, Lund, Sweden.,IHE – The Swedish Institute for Health Economics
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Swedish Inst Hlth Econ IHE, Lund, Sweden;Swedish Inst Hlth Econ, Rabygatan 2, S-22361 Lund, Sweden. IHE – The Swedish Institute for Health Economics (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: World Allergy Organization Journal. - : Elsevier. - 1939-4551. ; 17:4
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Abstract
Ämnesord
Stäng
- Background: Acute allergic reactions (AARs) occur shortly after exposure to an allergen, and the severity is on a continuum. Systemic corticosteroids (CS) are mainstay treatment of moderate to severe AARs, whereas those at risk of the most severe AARs (ie, anaphylaxis) are also recommended prescription of epinephrine autoinjectors. There is limited research on the impact of AARs not fulfilling the criteria for anaphylaxis. We have characterized a sample with a history of moderate to severe AARs and evaluated their self-reported disease burden (ie, daily life impact, anxiety, and treatment impediments).Methods: Survey study of adults with experience of AARs treated with CS. Participants recruited from a web-based panel and using social media were asked to complete a questionnaire related to their allergy and experience of AARs. The results were summarized for the whole sample and across subgroups with and without prescription of epinephrine.Results: The final study sample included 387 participants (80% women, mean age 41), of which 129 (33%) had at some point been prescribed epinephrine. The most common symptoms were respiratory (80%) and skin (78%) manifestations, and the mean (standard deviation, SD) self-rated severity score (scale from 0 [very mild] to 10 [very severe]) of the most recent AAR was 6.1 (2.0). More than 80% had experience of AARs interrupting daily activities and 50% of AARs that had limited work/studies or participation in leisure activities. Most of the respondents reported some degree of anxiety related to AARs and 43% had feared for their lives. Moreover, difficulties swallowing allergy medicine at an AAR was experienced by 26% and not having the medicine available when needed by 66%. Participants with prescription of epinephrine experienced more severe AARs than those without such prescription (mean [SD] severity 6.8 [2.1] vs 5.8 [1.8], p < 0.0001); however, also those without epinephrine prescription reported considerable anxiety and impact on daily life and to a similar degree as those with prescription.Conclusions: In this sample, subjects with experience of AARs treated with CS showed a considerable disease burden with anxiety and interruption on daily life, as well as problems related to access to, and swallowing of, medication. Although respondents with epinephrine prescription had more severe disease, a high disease burden was also evident among those without epinephrine. The study increases the knowledge of people with moderate to severe AARs, a patient population that has previously been underrepresented in the research literature.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Allergy
- Acute allergic reactions
- Disease burden
- Corticosteroids
- Anaphylaxis
- Acute allergic reactions
- Allergy
- Anaphylaxis
- Corticosteroids
- Disease burden
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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