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Increased mRNA Leve...
Abstract
Ämnesord
Stäng
- Several components in the Wnt pathway, including β-catenin and glycogen synthase kinase 3 beta, have been implied in AD pathogenesis. Here, mRNA brain levels from five-month-old tg-ArcSwe and nontransgenic mice were compared using Affymetrix microarray analysis. With surprisingly small overall changes, Wnt signaling was the most affected pathway with altered expression of nine genes in tg-ArcSwe mice. When analyzing mRNA levels of these genes in human brain, transcription factor 7-like 2 (TCF7L2) and v-myc myelocytomatosis viral oncogene homolog (MYC), were increased in Alzheimer's disease (AD) (P < .05). Furthermore, no clear differences in TCF7L2 and MYC mRNA were found in brains with frontotemporal lobar degeneration, suggesting that altered regulation of these Wnt-related genes could be specific to AD. Finally, mRNA levels of three neurogenesis markers were analyzed. Increased mRNA levels of dihydropyrimidinase-like 3 were observed in AD brain, suggesting that altered Wnt pathway regulation may signify synaptic rearrangement or neurogenesis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- MEDICINE
- MEDICIN
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- ref (ämneskategori)
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Blom, Elin S
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Wang, Yijing
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Skoglund, Lena
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Hansson, Anita C
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Ubaldi, Massimo
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Lourdusamy, Anba ...
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Sommer, Wolfgang ...
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Mielke, Matthew
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Hyman, Bradley T
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Heilig, Markus
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Lannfelt, Lars
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Nilsson, Lars N ...
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Ingelsson, Marti ...
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Uppsala universitet
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Högskolan Dalarna