Tyck till om SwePub Sök
här!
Sökning: onr:"swepub:oai:DiVA.org:gih-7377" >
Exercise training a...
Exercise training alters autoimmune cell invasion into the brain in autoimmune encephalomyelitis.
-
- Hamdi, Liel (författare)
- Department of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
-
- Nabat, Hanan (författare)
- Department of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
-
- Goldberg, Yehuda (författare)
- Department of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
-
visa fler...
-
- Fainstein, Nina (författare)
- Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
-
- Segal, Shir (författare)
- Department of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
-
- Mediouni, Efrat (författare)
- Department of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
-
- Asis, Yarden (författare)
- Department of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
-
- Touloumi, Olga (författare)
- B' Department of Neurology, AHEPA University Hospital of Thessaloniki, Greece.
-
- Grigoriadis, Nikolaos (författare)
- B' Department of Neurology, AHEPA University Hospital of Thessaloniki, Greece.
-
- Katz, Abram (författare)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
-
- Ben-Hur, Tamir (författare)
- Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
-
- Einstein, Ofira (författare)
- Department of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
-
visa färre...
-
Department of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah - Hebrew University Medical Center, Jerusalem, Israel. (creator_code:org_t)
- 2022-10-10
- 2022
- Engelska.
-
Ingår i: Annals of Clinical and Translational Neurology. - : Wiley-Blackwell. - 2328-9503. ; 9:11, s. 1792-1806
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://gih.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: The mechanisms by which exercise training (ET) elicits beneficial effects on the systemic immune system and the central nervous system (CNS) in autoimmune neuroinflammation are not fully understood.OBJECTIVES: To investigate (1) the systemic effects of high-intensity continuous training (HICT) on the migratory potential of autoimmune cells; (2) the direct effects of HICT on blood-brain-barrier (BBB) properties.METHODS: Healthy mice were subjected to high-intensity continuous training (HICT) by treadmill running. The proteolipid protein (PLP) transfer EAE model was utilized to examine the immunomodulatory effects of training, where PLP-reactive lymph-node cells (LNCs) from HICT and sedentary donor mice were analyzed in vitro and transferred to naïve recipients that developed EAE. To examine neuroprotection, encephalitogenic LNCs from donor mice were transferred into HICT or sedentary recipient mice and the BBB was analyzed.RESULTS: Transfer of PLP-reactive LNCs obtained from HICT donor mice attenuated EAE severity and inflammation in recipient mice. HICT markedly inhibited very late antigen (VLA)-4 and lymphocyte function-associated antigen (LFA)-1 expression in LNCs. Transfer of encephalitogenic LNCs into HICT recipients resulted in milder EAE and attenuated CNS inflammation. HICT reduced BBB permeability and the expression of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in CNS blood vessels.INTERPRETATION: HICT attenuates EAE development by both immunomodulatory and neuroprotective effects. The reduction in destructive CNS inflammation in EAE is attributed to systemic inhibition of autoreactive cell migratory potential, as well as reduction in BBB permeability, which are associated with reduced VLA-4/VCAM-1 and LFA-1/ICAM-1 interactions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Medicin/Teknik
- Medicine/Technology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hamdi, Liel
-
Nabat, Hanan
-
Goldberg, Yehuda
-
Fainstein, Nina
-
Segal, Shir
-
Mediouni, Efrat
-
visa fler...
-
Asis, Yarden
-
Touloumi, Olga
-
Grigoriadis, Nik ...
-
Katz, Abram
-
Ben-Hur, Tamir
-
Einstein, Ofira
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
- Artiklar i publikationen
-
Annals of Clinic ...
- Av lärosätet
-
Gymnastik- och idrottshögskolan