Sökning: WFRF:(Adami Hans Olov)
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Body mass index and...
Body mass index and risk of malignant lymphoma in Scandinavian men and women
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- Chang, Ellen T. (författare)
- Karolinska Institutet
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- Hjalgrim, Henrik (författare)
- Karolinska Institutet
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- Ekström Smedby, Karin (författare)
- Karolinska Institutet
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- Åkerman, Måns (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Tani, Edneia (författare)
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Johnsen, Hans E. (författare)
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- Glimelius, Bengt (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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Adami, Hans-Olov (författare)
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Melbye, Mads (författare)
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(creator_code:org_t)
- 2005-02-01
- 2005
- Engelska.
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 97:3, s. 210-218
- Relaterad länk:
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http://www.ncbi.nlm....
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http://jnci.oxfordjo...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The incidence of non-Hodgkin lymphoma and prevalence of obesity are increasing globally. A suggested positive association between obesity and risk of non-Hodgkin lymphoma has prompted us to investigate the relationship between body mass index (BMI) and risk of malignant lymphoma subtypes in a population-based case-control study. METHODS: Telephone interviews were conducted with 3055 case patients with non-Hodgkin lymphoma and 618 case patients with Hodgkin lymphoma diagnosed between October 1, 1999, and August 30, 2002, and 3187 population-based control subjects. The interviews assessed current height, normal adult weight, and other possible risk factors. Multivariable odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for risk of lymphoma were estimated by unconditional logistic regression. All statistical tests were two-sided. RESULTS: BMI was not associated with risk of overall non-Hodgkin lymphoma or of Hodgkin lymphoma (for example, comparing the highly obese group [BMI > or =35.0 kg/m2] with the normal-weight group [BMI = 18.5-24.9 kg/m2], OR for risk of non-Hodgkin lymphoma = 0.9, 95% CI = 0.6 to 1.3; P(trend) across all categories of BMI = .27). BMI was also not associated with risk of any non-Hodgkin lymphoma subtype evaluated, although there was some evidence of a positive association with risk of diffuse large B-cell lymphoma (for example, comparing the highly obese group with the normal-weight group, OR for diffuse large B-cell lymphoma = 1.5, 95% CI = 0.9 to 2.4; P(trend) =.05). CONCLUSIONS: Excess weight does not appear to be associated with an increased risk of malignant lymphoma in general, or with a risk of most major lymphoma subtypes. Hence, the growing incidence of obesity is unlikely to be an important contributor to the increasing incidence of non-Hodgkin lymphoma worldwide.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adult
- Aged
- Body Mass Index
- Case-Control Studies
- Confidence Intervals
- Confounding Factors (Epidemiology)
- Denmark/epidemiology
- Female
- Humans
- Incidence
- Logistic Models
- Lymphoma; B-Cell/epidemiology
- Lymphoma; Large-Cell/epidemiology
- Lymphoma; Non-Hodgkin/*epidemiology/etiology
- Male
- Middle Aged
- Obesity/*complications
- Odds Ratio
- Questionnaires
- Research Support; Non-U.S. Gov't
- Research Support; U.S. Gov't; P.H.S.
- Risk Assessment
- Risk Factors
- Selection Bias
- Sweden/epidemiology
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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