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Evaluation of cogni...
Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study
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- Overman, Margot J. (författare)
- University Hospitals Leuven
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- Pendleton, Neil (författare)
- University of Manchester
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- O’Neill, Terence W. (författare)
- University of Manchester
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- Bartfai, Gyorgy (författare)
- University of Szeged
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- Casanueva, Felipe F. (författare)
- Complejo Hospitalario Universitario de Santiago
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- Finn, Joseph D. (författare)
- University of Manchester
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- Forti, Gianni (författare)
- University of Florence
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- Rastrelli, Giulia (författare)
- University of Florence
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- Giwercman, Aleksander (författare)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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- Han, Thang S. (författare)
- Great Ormond Street Hospital
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- Huhtaniemi, Ilpo T. (författare)
- Imperial College London
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- Kula, Krzysztof (författare)
- Medical University of Lodz
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- Lean, Michael E J (författare)
- University of Glasgow
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- Punab, Margus (författare)
- University of Tartu
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- Lee, David M. (författare)
- University of Manchester
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- Correa, Elon S. (författare)
- University of Manchester
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- Ahern, Tomas (författare)
- University of Manchester
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- Verschueren, Sabine M P (författare)
- Catholic University of Leuven
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- Antonio, Leen (författare)
- Catholic University of Leuven
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- Gielen, Evelien (författare)
- University Hospitals Leuven
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- Rutter, Martin K. (författare)
- Great Ormond Street Hospital
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- Vanderschueren, Dirk (författare)
- Catholic University of Leuven
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- Wu, Frederick C W (författare)
- University of Manchester
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- Tournoy, Jos (författare)
- University Hospitals Leuven
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The Emas Study Group, Emas Study Group (författare)
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(creator_code:org_t)
- 2016-07-01
- 2017
- Engelska.
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Ingår i: European Journal of Nutrition. - : Springer Science and Business Media LLC. - 1436-6207 .- 1436-6215. ; 56:6, s. 2093-2103
- Relaterad länk:
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http://dx.doi.org/10...
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http://eprints.gla.a...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Purpose: Although lower levels of vitamin D have been related to poor cognitive functioning and dementia in older adults, evidence from longitudinal investigations is inconsistent. The objective of this study was to determine whether 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] levels are associated with specified measures of cognitive decline in ageing men. Methods: The European Male Ageing Study (EMAS) followed 3369 men aged 40–79 over 4.4 years. 25(OH)D levels at baseline were measured by radioimmunoassay, and 1,25(OH)2D levels were obtained with liquid chromatography–tandem mass spectrometry. Visuoconstructional abilities, visual memory, and processing speed at baseline and follow-up were assessed using the Rey–Osterrieth Complex Figure Test (ROCF), Camden Topographical Recognition Memory (CTRM), and the Digit Symbol Substitution Test (DSST). Results: Following attritions, a total of 2430 men with a mean (SD) age of 59.0 (10.6) were included in the analyses. At baseline, the mean 25(OH)D concentration was 64.6 (31.5) nmol/l, and mean 1,25(OH)2D level was 59.6 (16.6) pmol/l. In age-adjusted linear regression models, high 25(OH)D concentrations were associated with a smaller decline in the DSST (β = 0.007, p = 0.020). Men with low 25(OH)D levels (2D and decline in cognitive subdomains. Conclusion: We found no evidence for an independent association between 25(OH)D or 1,25(OH)2D levels and visuoconstructional abilities, visual memory, or processing speed over on average 4.4 years in this sample of middle-aged and elderly European men.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Ageing
- Cognition
- Male health
- Multicenter study
- Vitamin D
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Overman, Margot ...
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Pendleton, Neil
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O’Neill, Terence ...
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Bartfai, Gyorgy
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Casanueva, Felip ...
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Finn, Joseph D.
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visa fler...
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Forti, Gianni
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Rastrelli, Giuli ...
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Giwercman, Aleks ...
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Han, Thang S.
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Huhtaniemi, Ilpo ...
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Kula, Krzysztof
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Lean, Michael E ...
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Punab, Margus
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Lee, David M.
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Correa, Elon S.
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Ahern, Tomas
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Verschueren, Sab ...
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Antonio, Leen
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Gielen, Evelien
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Rutter, Martin K ...
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Vanderschueren, ...
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Wu, Frederick C ...
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Tournoy, Jos
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The Emas Study G ...
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