Sökning: WFRF:(Ahlström Håkan) >
Plasma-parathyroid ...
Plasma-parathyroid hormone is associated with subclinical and clinical atherosclerotic disease in 2 community-based cohorts
-
- Hagström, Emil (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Clinical Research Center ; Medical Sciences Uppsala University, Uppsala, Sweden
-
- Michaëlsson, Karl, 1959- (författare)
- Uppsala universitet,Ortopedi,Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Ortopedi
-
- Melhus, Håkan (författare)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Institutionen för medicinska vetenskaper, Klinisk farmakogenomik och osteoporos, Uppsala University, Uppsala, Sweden
-
visa fler...
-
- Hansen, Tomas (författare)
- Uppsala universitet,Enheten för radiologi,Departments of Radiology, Uppsala University, Uppsala, Sweden
-
- Ahlström, Håkan (författare)
- Uppsala universitet,Enheten för radiologi,Departments of Radiology, Uppsala University, Uppsala, Sweden
-
- Johansson, Lars (författare)
- Uppsala universitet,Enheten för radiologi,Departments of Radiology, Uppsala University, Uppsala, Sweden
-
- Ingelsson, Erik (författare)
- Uppsala universitet,Molekylär epidemiologi,Uppsala Clinical Research Center ; Medical Sciences Uppsala University, Uppsala, Sweden
-
- Sundström, Johan (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Clinical Research Center ; Medical Sciences Uppsala University, Uppsala, Sweden
-
- Lind, Lars (författare)
- Uppsala universitet,Kardiovaskulär epidemiologi,Medical Sciences Uppsala University, Uppsala, Sweden
-
- Ärnlöv, Johan, 1970- (författare)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Medical Sciences Uppsala University, Uppsala, Sweden,Molekylär epidemiologi
-
visa färre...
-
(creator_code:org_t)
- 2014
- 2014
- Engelska.
-
Ingår i: Arteriosclerosis, Thrombosis and Vascular Biology. - 1079-5642 .- 1524-4636. ; 34:7, s. 1567-1579
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE: Cardiovascular risk factors have different impact on different arterial territories. Diseases with elevated circulating parathyroid hormone (PTH) such as primary hyperparathyroidism and chronic renal failure have been shown to be associated with an increased risk of cardiovascular disease, predominantly heart or cerebrovascular diseases. However, data on the associations between circulating PTH and peripheral atherosclerosis are limited.APPROACH AND RESULTS: Two prospective, community-based studies were used. In 306 men and women, who were 70 years old, from the Prospective investigation of the vasculature in Uppsala seniors (PIVUS) study, cross-sectional relations between PTH and atherosclerotic burden assessed by whole-body magnetic resonance angiography were investigated. In 998 men, who were 71 years old, from the Uppsala longitudinal study of adult men (ULSAM) study, the association between PTH concentration and risk of subsequent nonfatal atherosclerotic disease (excluding coronary or cerebrovascular disease) was investigated. Adjusting for established vascular risk factors, PTH was associated with burden of atherosclerosis (increase in total atherosclerotic score per SD PTH increase: 0.04, 0.003-0.08; P=0.03) in the PIVUS study. During follow-up in the ULSAM study (median 16.7 years), 89 men were diagnosed with nonfatal atherosclerotic disease. In Cox-regression analyses adjusting for established vascular risk factors and mineral metabolism, higher PTH was associated with an increased risk of nonfatal atherosclerotic disease (hazard ratio for 1 SD increase of PTH: 1.55, 1.33-1.88; P<0.0001). Results were similar when including fatal atherosclerotic disease in the outcome.CONCLUSIONS: In 2 independent community-based cohorts, PTH was associated to the degree of atherosclerosis and risk of clinically overt atherosclerotic disease, respectively. Our data confirm and extend previous studies supporting a role for PTH in the development of atherosclerotic disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- atherosclerosis; magnetic resonance angiography; parathyroid hormone; population
- Hälsa och välfärd
- Health and Welfare
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hagström, Emil
-
Michaëlsson, Kar ...
-
Melhus, Håkan
-
Hansen, Tomas
-
Ahlström, Håkan
-
Johansson, Lars
-
visa fler...
-
Ingelsson, Erik
-
Sundström, Johan
-
Lind, Lars
-
Ärnlöv, Johan, 1 ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Arteriosclerosis ...
- Av lärosätet
-
Högskolan Dalarna
-
Uppsala universitet