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Monoamine metabolit...
Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression.
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Kishida, Ikuko (författare)
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- Aklillu, Eleni (författare)
- Karolinska Institutet
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Kawanishi, Chiaki (författare)
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- Bertilsson, Leif (författare)
- Karolinska Institutet
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- Ågren, Hans, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2007-02-14
- 2007
- Engelska.
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Ingår i: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. - : Springer Science and Business Media LLC. - 0893-133X. ; 32:10, s. 2143-51
- Relaterad länk:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The serotonin (5-hydroxytryptamine) transporter (5-HTT) is considered to affect the pathogenesis of mood disorders. Large number of genetic association studies between 5-HTT functional polymorphisms and vulnerability of mood disorders and therapeutic response to antidepressants has been carried out. We investigated the influence of 5-HTT-linked polymorphic region (5-HTTLPR) and 5-HTT 17 bp variable number of tandem repeat polymorphism (5-HTTVNTR) polymorphisms on concentrations of monoamine metabolites in cerebrospinal fluid (CSF) among treatment-resistant patients with mood disorders. Subjects were 119 Swedish patients with persistent mood disorders and 141 healthy subjects. In 112 of these patients, we measured 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol in CSF. Genotyping for 5-HTT polymorphisms from genomic DNA was carried out by PCR. There was no significant difference in allele/genotype frequency between patients and healthy subjects. In patients with mood disorders, we found significant difference in mean 5-HIAA concentration between 5-HTTLPR genotypes (p=0.03). Although the 5-HIAA concentration showed a tendency to be higher in short (S) carriers than in non-S carriers of the 5-HTTLPR in patients (p=0.06), when considering patients with major depressive disorder (MDD), the 5-HIAA concentration was significantly higher among S carriers than among non-S carriers (p=0.02). Moreover, the 5-HIAA concentration was higher in S/S subjects compared to long (L)/L (p=0.0001) and L/S (p=0.002) subjects in patients with MDD. Similarly, there was higher HVA concentration in S/S subjects compared to L/L (p=0.002) and L/S subjects (p=0.002). There was no effect of 5-HTTVNTR. Our findings show that the 5-HTTLPR polymorphism affects 5-HIAA and HVA concentrations among treatment-resistant patients with mood disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Adult
- Aged
- Biogenic Monoamines
- cerebrospinal fluid
- Brain Chemistry
- genetics
- DNA Mutational Analysis
- Depressive Disorder
- cerebrospinal fluid
- genetics
- physiopathology
- Drug Resistance
- genetics
- Female
- Genetic Predisposition to Disease
- genetics
- Genetic Screening
- Genotype
- Homovanillic Acid
- cerebrospinal fluid
- Humans
- Hydroxyindoleacetic Acid
- cerebrospinal fluid
- Male
- Methoxyhydroxyphenylglycol
- analogs & derivatives
- cerebrospinal fluid
- Middle Aged
- Mutation
- genetics
- Polymorphism
- Genetic
- genetics
- Serotonin Plasma Membrane Transport Proteins
- genetics
- Tandem Repeat Sequences
- genetics
- Up-Regulation
- physiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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