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Sökning: onr:"swepub:oai:DiVA.org:umu-198568" > Cross-ancestry geno...

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

Byun, Jinyoung (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States
Han, Younghun (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States
Li, Yafang (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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Xia, Jun (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States
Long, Erping (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Choi, Jiyeon (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Xiao, Xiangjun (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
Zhu, Meng (författare)
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Zhou, Wen (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
Sun, Ryan (författare)
Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center, TX, Houston, United States
Bossé, Yohan (författare)
Institut universitaire de cardiologie et de pneumologie de Québec – Université Laval, Department of Molecular Medicine, Laval University, QC, Quebec City, Canada
Song, Zhuoyi (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States
Schwartz, Ann (författare)
Department of Oncology, Wayne State University School of Medicine, MI, Detroit, United States; Karmanos Cancer Institute, MI, Detroit, United States
Lusk, Christine (författare)
Department of Oncology, Wayne State University School of Medicine, MI, Detroit, United States; Karmanos Cancer Institute, MI, Detroit, United States
Rafnar, Thorunn (författare)
deCODE genetics/Amgen Sturlugata 8, Reykjavik, Iceland
Stefansson, Kari (författare)
deCODE genetics/Amgen Sturlugata 8, Reykjavik, Iceland
Zhang, Tongwu (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Zhao, Wei (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Pettit, Rowland W. (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
Liu, Yanhong (författare)
Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
Li, Xihao (författare)
Department of Biostatistics, Harvard TH Chan School of Public Health, MA, Boston, United States
Zhou, Hufeng (författare)
Department of Biostatistics, Harvard TH Chan School of Public Health, MA, Boston, United States
Walsh, Kyle M. (författare)
Duke Cancer Institute, Duke University Medical Center, NC, Durham, United States
Gorlov, Ivan (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
Gorlova, Olga (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
Zhu, Dakai (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States
Rosenberg, Susan M. (författare)
Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States
Pinney, Susan (författare)
University of Cincinnati College of Medicine, OH, Cincinnati, United States
Bailey-Wilson, Joan E. (författare)
National Human Genome Research Institute, NIH, MD, Baltimore, United States
Mandal, Diptasri (författare)
Louisiana State University Health Sciences Center, LA, New Orleans, United States
de Andrade, Mariza (författare)
Mayo Clinic, College of Medicine, MN, Rochester, United States
Gaba, Colette (författare)
The University of Toledo College of Medicine and Life Sciences, University of Toledo, OH, Toledo, United States
Willey, James C. (författare)
The University of Toledo College of Medicine and Life Sciences, University of Toledo, OH, Toledo, United States
You, Ming (författare)
Center for Cancer Prevention, Houston Methodist Research Institute, TX, Houston, United States
Anderson, Marshall (författare)
University of Cincinnati College of Medicine, OH, Cincinnati, United States
Wiencke, John K. (författare)
Department of Neurological Surgery, University of California, San Francisco, CA, San Francisco, United States
Albanes, Demetrius (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Lam, Stephan (författare)
Department of Integrative Oncology, BC Cancer, BC, Vancouver, Canada
Tardon, Adonina (författare)
Public Health Department, University of Oviedo, ISPA and CIBERESP, Asturias, Spain
Chen, Chu (författare)
Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Baylor College of Medicine
Goodman, Gary (författare)
Swedish Cancer Institute, WA, Seattle, United States
Bojeson, Stig (författare)
Department of Clinical Biochemistry, Herlev Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Landi, Maria Teresa (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Chanock, Stephen J. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Johansson, Mattias (författare)
Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
Muley, Thomas (författare)
Division of Cancer Epigenomics, DKFZ – German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany
Risch, Angela (författare)
Division of Cancer Epigenomics, DKFZ – German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany; Department of Biosciences and Medical Biology, Allergy-Cancer-BioNano Research Centre, University of Salzburg, Salzburg, Austria; Cancer Cluster Salzburg, Salzburg, Austria
Wichmann, H.-Erich (författare)
Institute of Epidemiology, Helmholtz Center, Munich, Germany
Bickeböller, Heike (författare)
Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany
Christiani, David C. (författare)
Department of Epidemiology, Harvard T.H.Chan School of Public Health, MA, Boston, United States
Rennert, Gad (författare)
Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
Arnold, Susanne (författare)
University of Kentucky, Markey Cancer Center, KY, Lexington, United States
Field, John K. (författare)
Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
Shete, Sanjay (författare)
Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center, TX, Houston, United States; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, TX, Houston, United States
Le Marchand, Loic (författare)
Epidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States
Melander, O. (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Brunnstrom, H. (författare)
Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
Liu, Geoffrey (författare)
University Health Network- The Princess Margaret Cancer Centre, Ontario, Toronto, Canada
Andrew, Angeline S. (författare)
Departments of Epidemiology and Community and Family Medicine, Dartmouth College, NH, Hanover, United States
Kiemeney, Lambertus A. (författare)
Radboud University Medical Center, Nijmegen, Netherlands
Shen, Hongbing (författare)
Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China
Zienolddiny, Shanbeh (författare)
National Institute of Occupational Health, Oslo, Norway
Grankvist, Kjell (författare)
Umeå universitet,Klinisk kemi
Johansson, Mikael (författare)
Umeå universitet,Onkologi
Caporaso, Neil (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Cox, Angela (författare)
Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom
Hong, Yun-Chul (författare)
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
Yuan, Jian-Min (författare)
UPMC Hillman Cancer Center and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
Lazarus, Philip (författare)
Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States
Schabath, Matthew B. (författare)
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States
Aldrich, Melinda C. (författare)
Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
Patel, Alpa (författare)
American Cancer Society, GA, Atlanta, United States
Lan, Qing (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Rothman, Nathaniel (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Taylor, Fiona (författare)
Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom
Kachuri, Linda (författare)
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, San Francisco, United States
Witte, John S. (författare)
Department of Epidemiology and Population Health, Stanford University, CA, Stanford, United States
Sakoda, Lori C. (författare)
Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Spitz, Margaret (författare)
Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States
Brennan, Paul (författare)
Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
Lin, Xihong (författare)
Department of Biostatistics, Harvard TH Chan School of Public Health, MA, Boston, United States
McKay, James (författare)
Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
Hung, Rayjean J. (författare)
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, ON, Toronto, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, ON, Toronto, Canada
Amos, Christopher I. (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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 (creator_code:org_t)
et al 
2022-08-01
2022
Engelska.
Ingår i: Nature Genetics. - : Nature Research. - 1061-4036 .- 1546-1718. ; 54:8, s. 1167-1177
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Nyckelord

DNA binding protein
FUBP1 protein, human
RNA binding protein
genetic predisposition
genetics
genome-wide association study
human
lung tumor
meta analysis
quantitative trait locus
single nucleotide polymorphism
DNA-Binding Proteins
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Lung Neoplasms
Polymorphism, Single Nucleotide
Quantitative Trait Loci
RNA-Binding Proteins

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Av författaren/redakt...
Byun, Jinyoung
Han, Younghun
Li, Yafang
Xia, Jun
Long, Erping
Choi, Jiyeon
visa fler...
Xiao, Xiangjun
Zhu, Meng
Zhou, Wen
Sun, Ryan
Bossé, Yohan
Song, Zhuoyi
Schwartz, Ann
Lusk, Christine
Rafnar, Thorunn
Stefansson, Kari
Zhang, Tongwu
Zhao, Wei
Pettit, Rowland ...
Liu, Yanhong
Li, Xihao
Zhou, Hufeng
Walsh, Kyle M.
Gorlov, Ivan
Gorlova, Olga
Zhu, Dakai
Rosenberg, Susan ...
Pinney, Susan
Bailey-Wilson, J ...
Mandal, Diptasri
de Andrade, Mari ...
Gaba, Colette
Willey, James C.
You, Ming
Anderson, Marsha ...
Wiencke, John K.
Albanes, Demetri ...
Lam, Stephan
Tardon, Adonina
Chen, Chu
Goodman, Gary
Bojeson, Stig
Brenner, Hermann
Landi, Maria Ter ...
Chanock, Stephen ...
Johansson, Matti ...
Muley, Thomas
Risch, Angela
Wichmann, H.-Eri ...
Bickeböller, Hei ...
Christiani, Davi ...
Rennert, Gad
Arnold, Susanne
Field, John K.
Shete, Sanjay
Le Marchand, Loi ...
Melander, O.
Brunnstrom, H.
Liu, Geoffrey
Andrew, Angeline ...
Kiemeney, Lamber ...
Shen, Hongbing
Zienolddiny, Sha ...
Grankvist, Kjell
Johansson, Mikae ...
Caporaso, Neil
Cox, Angela
Hong, Yun-Chul
Yuan, Jian-Min
Lazarus, Philip
Schabath, Matthe ...
Aldrich, Melinda ...
Patel, Alpa
Lan, Qing
Rothman, Nathani ...
Taylor, Fiona
Kachuri, Linda
Witte, John S.
Sakoda, Lori C.
Spitz, Margaret
Brennan, Paul
Lin, Xihong
McKay, James
Hung, Rayjean J.
Amos, Christophe ...
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