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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Schunkert, Heribert (author)
Koenig, Inke R. (author)
Kathiresan, Sekar (author)
show more...
Reilly, Muredach P. (author)
Assimes, Themistocles L. (author)
Holm, Hilma (author)
Preuss, Michael (author)
Stewart, Alexandre F. R. (author)
Barbalic, Maja (author)
Gieger, Christian (author)
Absher, Devin (author)
Aherrahrou, Zouhair (author)
Allayee, Hooman (author)
Altshuler, David (author)
Anand, Sonia S. (author)
Andersen, Karl (author)
Anderson, Jeffrey L. (author)
Ardissino, Diego (author)
Ball, Stephen G. (author)
Karolinska Institutet
Balmforth, Anthony J. (author)
Barnes, Timothy A. (author)
Becker, Diane M. (author)
Becker, Lewis C. (author)
Berger, Klaus (author)
Bis, Joshua C. (author)
Boekholdt, S. Matthijs (author)
Boerwinkle, Eric (author)
Braund, Peter S. (author)
Brown, Morris J. (author)
Burnett, Mary Susan (author)
Buysschaert, Ian (author)
Carlquist, John F. (author)
Chen, Li (author)
Cichon, Sven (author)
Codd, Veryan (author)
Davies, Robert W. (author)
Dedoussis, George (author)
Dehghan, Abbas (author)
Demissie, Serkalem (author)
Devaney, Joseph M. (author)
Diemert, Patrick (author)
Do, Ron (author)
Doering, Angela (author)
Eifert, Sandra (author)
El Mokhtari, Nour Eddine (author)
Ellis, Stephen G. (author)
Elosua, Roberto (author)
Engert, James C. (author)
Epstein, Stephen E. (author)
de Faire, Ulf (author)
Karolinska Institutet
Fischer, Marcus (author)
Folsom, Aaron R. (author)
Freyer, Jennifer (author)
Gigante, Bruna (author)
Girelli, Domenico (author)
Gretarsdottir, Solveig (author)
Gudnason, Vilmundur (author)
Gulcher, Jeffrey R. (author)
Halperin, Eran (author)
Hammond, Naomi (author)
Hazen, Stanley L. (author)
Hofman, Albert (author)
Horne, Benjamin D. (author)
Illig, Thomas (author)
Iribarren, Carlos (author)
Jones, Gregory T. (author)
Jukema, J. Wouter (author)
Kaiser, Michael A. (author)
Kaplan, Lee M. (author)
Kastelein, John J. P. (author)
Khaw, Kay-Tee (author)
Knowles, Joshua W. (author)
Kolovou, Genovefa (author)
Kong, Augustine (author)
Laaksonen, Reijo (author)
Lambrechts, Diether (author)
Leander, Karin (author)
Karolinska Institutet
Lettre, Guillaume (author)
Li, Mingyao (author)
Lieb, Wolfgang (author)
Loley, Christina (author)
Lotery, Andrew J. (author)
Mannucci, Pier M. (author)
Maouche, Seraya (author)
Martinelli, Nicola (author)
McKeown, Pascal P. (author)
Meisinger, Christa (author)
Meitinger, Thomas (author)
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Merlini, Pier Angelica (author)
Mooser, Vincent (author)
Morgan, Thomas (author)
Muehleisen, Thomas W. (author)
Muhlestein, Joseph B. (author)
Muenzel, Thomas (author)
Musunuru, Kiran (author)
nahrstaedt, Janja (author)
Nelson, Christopher P. (author)
Noethen, Markus M. (author)
Olivieri, Oliviero (author)
Patel, Riyaz S. (author)
Patterson, Chris C. (author)
Peters, Annette (author)
Peyvandi, Flora (author)
Qu, Liming (author)
Quyyumi, Arshed A. (author)
Rader, Daniel J. (author)
Rallidis, Loukianos S. (author)
Rice, Catherine (author)
Rosendaal, Frits R. (author)
Rubin, Diana (author)
Salomaa, Veikko (author)
Sampietro, M. Lourdes (author)
Sandhu, Manj S. (author)
Schadt, Eric (author)
Schaefer, Arne (author)
Schillert, Arne (author)
Schreiber, Stefan (author)
Schrezenmeir, Juergen (author)
Schwartz, Stephen M. (author)
Siscovick, David S. (author)
Sivananthan, Mohan (author)
Sivapalaratnam, Suthesh (author)
Smith, Albert (author)
Smith, Tamara B. (author)
Snoep, Jaapjan D. (author)
Soranzo, Nicole (author)
Spertus, John A. (author)
Stark, Klaus (author)
Stirrups, Kathy (author)
Stoll, Monika (author)
Tang, W. H. Wilson (author)
Tennstedt, Stephanie (author)
Thorgeirsson, Gudmundur (author)
Thorleifsson, Gudmar (author)
Tomaszewski, Maciej (author)
Uitterlinden, Andre G. (author)
van Rij, Andre M. (author)
Voight, Benjamin F. (author)
Wareham, Nick J. (author)
Wells, George A. (author)
Wichmann, H-Erich (author)
Wild, Philipp S. (author)
Willenborg, Christina (author)
Witteman, Jaqueline C. M. (author)
Wright, Benjamin J. (author)
Ye, Shu (author)
Zeller, Tanja (author)
Ziegler, Andreas (author)
Cambien, Francois (author)
Goodall, Alison H. (author)
Cupples, L. Adrienne (author)
Quertermous, Thomas (author)
Maerz, Winfried (author)
Hengstenberg, Christian (author)
Blankenberg, Stefan (author)
Ouwehand, Willem H. (author)
Hall, Alistair S. (author)
Deloukas, Panos (author)
Thompson, John R. (author)
Stefansson, Kari (author)
Roberts, Robert (author)
Thorsteinsdottir, Unnur (author)
O'Donnell, Christopher J. (author)
McPherson, Ruth (author)
Erdmann, Jeanette (author)
Samani, Nilesh J. (author)
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 (creator_code:org_t)
2011-03-06
2011
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:4, s. 153-333
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

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By the author/editor
Schunkert, Herib ...
Koenig, Inke R.
Kathiresan, Seka ...
Reilly, Muredach ...
Assimes, Themist ...
Holm, Hilma
show more...
Preuss, Michael
Stewart, Alexand ...
Barbalic, Maja
Gieger, Christia ...
Absher, Devin
Aherrahrou, Zouh ...
Allayee, Hooman
Altshuler, David
Anand, Sonia S.
Andersen, Karl
Anderson, Jeffre ...
Ardissino, Diego
Ball, Stephen G.
Balmforth, Antho ...
Barnes, Timothy ...
Becker, Diane M.
Becker, Lewis C.
Berger, Klaus
Bis, Joshua C.
Boekholdt, S. Ma ...
Boerwinkle, Eric
Braund, Peter S.
Brown, Morris J.
Burnett, Mary Su ...
Buysschaert, Ian
Carlquist, John ...
Chen, Li
Cichon, Sven
Codd, Veryan
Davies, Robert W ...
Dedoussis, Georg ...
Dehghan, Abbas
Demissie, Serkal ...
Devaney, Joseph ...
Diemert, Patrick
Do, Ron
Doering, Angela
Eifert, Sandra
El Mokhtari, Nou ...
Ellis, Stephen G ...
Elosua, Roberto
Engert, James C.
Epstein, Stephen ...
de Faire, Ulf
Fischer, Marcus
Folsom, Aaron R.
Freyer, Jennifer
Gigante, Bruna
Girelli, Domenic ...
Gretarsdottir, S ...
Gudnason, Vilmun ...
Gulcher, Jeffrey ...
Halperin, Eran
Hammond, Naomi
Hazen, Stanley L ...
Hofman, Albert
Horne, Benjamin ...
Illig, Thomas
Iribarren, Carlo ...
Jones, Gregory T ...
Jukema, J. Woute ...
Kaiser, Michael ...
Kaplan, Lee M.
Kastelein, John ...
Khaw, Kay-Tee
Knowles, Joshua ...
Kolovou, Genovef ...
Kong, Augustine
Laaksonen, Reijo
Lambrechts, Diet ...
Leander, Karin
Lettre, Guillaum ...
Li, Mingyao
Lieb, Wolfgang
Loley, Christina
Lotery, Andrew J ...
Mannucci, Pier M ...
Maouche, Seraya
Martinelli, Nico ...
McKeown, Pascal ...
Meisinger, Chris ...
Meitinger, Thoma ...
Melander, Olle
Merlini, Pier An ...
Mooser, Vincent
Morgan, Thomas
Muehleisen, Thom ...
Muhlestein, Jose ...
Muenzel, Thomas
Musunuru, Kiran
nahrstaedt, Janj ...
Nelson, Christop ...
Noethen, Markus ...
Olivieri, Olivie ...
Patel, Riyaz S.
Patterson, Chris ...
Peters, Annette
Peyvandi, Flora
Qu, Liming
Quyyumi, Arshed ...
Rader, Daniel J.
Rallidis, Loukia ...
Rice, Catherine
Rosendaal, Frits ...
Rubin, Diana
Salomaa, Veikko
Sampietro, M. Lo ...
Sandhu, Manj S.
Schadt, Eric
Schaefer, Arne
Schillert, Arne
Schreiber, Stefa ...
Schrezenmeir, Ju ...
Schwartz, Stephe ...
Siscovick, David ...
Sivananthan, Moh ...
Sivapalaratnam, ...
Smith, Albert
Smith, Tamara B.
Snoep, Jaapjan D ...
Soranzo, Nicole
Spertus, John A.
Stark, Klaus
Stirrups, Kathy
Stoll, Monika
Tang, W. H. Wils ...
Tennstedt, Steph ...
Thorgeirsson, Gu ...
Thorleifsson, Gu ...
Tomaszewski, Mac ...
Uitterlinden, An ...
van Rij, Andre M ...
Voight, Benjamin ...
Wareham, Nick J.
Wells, George A.
Wichmann, H-Eric ...
Wild, Philipp S.
Willenborg, Chri ...
Witteman, Jaquel ...
Wright, Benjamin ...
Ye, Shu
Zeller, Tanja
Ziegler, Andreas
Cambien, Francoi ...
Goodall, Alison ...
Cupples, L. Adri ...
Quertermous, Tho ...
Maerz, Winfried
Hengstenberg, Ch ...
Blankenberg, Ste ...
Ouwehand, Willem ...
Hall, Alistair S ...
Deloukas, Panos
Thompson, John R ...
Stefansson, Kari
Roberts, Robert
Thorsteinsdottir ...
O'Donnell, Chris ...
McPherson, Ruth
Erdmann, Jeanett ...
Samani, Nilesh J ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
Articles in the publication
Nature Genetics
By the university
Lund University
Karolinska Institutet

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