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Sökning: onr:"swepub:oai:DiVA.org:umu-199395" > Genome-wide interac...

Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk

Li, Yafang (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
Xiao, Xiangjun (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States
Li, Jianrong (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States
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Byun, Jinyoung (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States
Cheng, Chao (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
Bossé, Yohan (författare)
Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Canada
McKay, James (författare)
Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
Albanes, Demetrios (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States
Lam, Stephen (författare)
Department of Integrative Oncology, University of British Columbia, Vancouver, Canada
Tardon, Adonina (författare)
Public Health Department, University of Oviedo, Asturias, Spain
Chen, Chu (författare)
Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Bojesen, Stig E. (författare)
Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2177, Denmark
Landi, Maria T. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States
Johansson, Mattias (författare)
Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
Risch, Angela (författare)
Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany; University of Salzburg and Cancer Cluster Salzburg, Austria
Bickeböller, Heike (författare)
Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Germany
Wichmann, H-Erich (författare)
Institute of Medical Statistics and Epidemiology, Technical University Munich, Germany
Christiani, David C. (författare)
Departments of Environmental Health and Epidemiology, Harvard TH Chan School of Public Health, Boston, United States
Rennert, Gad (författare)
Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
Arnold, Susanne (författare)
University of Kentucky, Markey Cancer Center, KY, Lexington, United States
Goodman, Gary (författare)
Swedish Cancer Institute, Seattle, WA 98104, USA
Field, John K. (författare)
Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
Davies, Michael P A (författare)
Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
Shete, Sanjay S. (författare)
Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center, Houston, United States; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, United States
Le Marchand, Loic (författare)
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, United States
Melander, O. (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Brunnström, H. (författare)
Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
Liu, Geoffrey (författare)
University Health Network- The Princess Margaret Cancer Centre, Toronto, Canada
Hung, Rayjean J. (författare)
Luenfeld-Tanenbaum Research Institute, Sinai Health System, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Canada
Andrew, Angeline S. (författare)
Departments of Epidemiology and Community and Family Medicine, Dartmouth College, Hanover, United States
Kiemeney, Lambertus A. (författare)
Radboud University Medical Center, Nijmegen, Netherlands
Shen, Hongbing (författare)
Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China
Sun, Ryan (författare)
Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center, Houston, United States
Zienolddiny, Shan (författare)
National Institute of Occupational Health, Oslo, Norway
Grankvist, Kjell (författare)
Umeå universitet,Klinisk kemi
Johansson, Mikael (författare)
Umeå universitet,Onkologi
Caporaso, Neil (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States
Teare, Dawn M. (författare)
Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
Hong, Yun-Chul (författare)
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
Lazarus, Philip (författare)
Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States
Schabath, Matthew B. (författare)
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States
Aldrich, Melinda C. (författare)
Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center Nashville, United States
Schwartz, Ann G. (författare)
Department of Oncology, Wayne State University School of Medicine, Detroit, United States; Karmanos Cancer Institute, Detroit, United States
Gorlov, Ivan (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
Purrington, Kristen (författare)
Karmanos Cancer Institute, Detroit, United States
Yang, Ping (författare)
Division of Epidemiology, Department of Health Sciences Research, MN, United States
Liu, Yanhong (författare)
Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
Han, Younghun (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States
Bailey-Wilson, Joan E. (författare)
National Human Genome Research Institute, NIH, Baltimore, United States
Pinney, Susan M. (författare)
University of Cincinnati College of Medicine, Cincinnati, United States
Mandal, Diptasri (författare)
Louisiana State University Health Sciences Center, New Orleans, United States
Willey, James C. (författare)
College of Medicine and Life Sciences, University of Toledo, Toledo, United States
Gaba, Colette (författare)
University of Toledo College of Medicine, Toledo, United States
Brennan, Paul (författare)
Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
Amos, Christopher I. (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, United States
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 (creator_code:org_t)
et al 
2022-02-09
2022
Engelska.
Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 31:16, s. 2831-2843
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene-sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency < 0.05), rs17662871 [odds ratio (OR) = 0.71, P = 4.29×10-8); rs79942605 (OR = 2.17, P = 2.81×10-8) and rs208908 (OR = 0.70, P = 4.54×10-8) were identified with different risk effect of lung cancer between men and women. Further expression quantitative trait loci and functional annotation analysis suggested rs208908 affects lung cancer risk through differential regulation of Coxsackie virus and adenovirus receptor gene expression in lung tissues between men and women. Our study is one of the first studies to provide novel insights about the genetic and molecular basis for sex disparity in lung cancer development.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

case control study
female
genetic predisposition
genetics
genome-wide association study
human
lung
lung tumor
male
single nucleotide polymorphism
Case-Control Studies
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Lung
Lung Neoplasms
Male
Polymorphism, Single Nucleotide

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