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Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder.

Amare, Azmeraw (author)
Thalamuthu, Anbupalam (author)
Schubert, Klaus Oliver (author)
show more...
Fullerton, Janice (author)
Ahmed, Muktar (author)
Hartmann, Simon (author)
Papiol, Sergi (author)
Heilbronner, Urs (author)
Degenhardt, Franziska (author)
Tekola-Ayele, Fasil (author)
Hou, Liping (author)
Hsu, Yi-Hsiang (author)
Shekhtman, Tatyana (author)
Adli, Mazda (author)
Akula, Nirmala (author)
Akiyama, Kazufumi (author)
Ardau, Raffaella (author)
Arias, Bárbara (author)
Aubry, Jean-Michel (author)
Backlund, Lena (author)
Karolinska Institutet
Bhattacharjee, Abesh Kumar (author)
Bellivier, Frank (author)
Benabarre, Antoni (author)
Bengesser, Susanne (author)
Biernacka, Joanna (author)
Birner, Armin (author)
Marie-Claire, Cynthia (author)
Cervantes, Pablo (author)
Chen, Hsi-Chung (author)
Chillotti, Caterina (author)
Karolinska Institutet
Cichon, Sven (author)
Cruceanu, Cristiana (author)
Czerski, Piotr (author)
Dalkner, Nina (author)
Zompo, Maria Del (author)
DePaulo, J Raymond (author)
Etain, Bruno (author)
Jamain, Stéphane (author)
Falkai, Peter (author)
Forstner, Andreas J (author)
Frisén, Louise (author)
Karolinska Institutet
Frye, Mark (author)
Gard, Sébastien (author)
Garnham, Julie (author)
Goes, Fernando (author)
Grigoroiu-Serbanescu, Maria (author)
Fallgatter, Andreas (author)
Stegmaier, Sophia (author)
Ethofer, Thomas (author)
Biere, Silvia (author)
Petrova, Kristiyana (author)
Schuster, Ceylan (author)
Adorjan, Kristina (author)
Budde, Monika (author)
Heilbronner, Maria (author)
Kalman, Janos (author)
Kohshour, Mojtaba Oraki (author)
Reich-Erkelenz, Daniela (author)
Schaupp, Sabrina (author)
Schulte, Eva (author)
Senner, Fanny (author)
Vogl, Thomas (author)
Anghelescu, Ion-George (author)
Arolt, Volker (author)
Dannlowski, Udo (author)
Dietrich, Detlef E (author)
Figge, Christian (author)
Jäger, Markus (author)
Lang, Fabian (author)
Juckel, Georg (author)
Spitzer, Carsten (author)
Reimer, Jens (author)
Schmauß, Max (author)
Schmitt, Andrea (author)
Konrad, Carsten (author)
von Hagen, Martin (author)
Wiltfang, Jens (author)
Zimmermann, Jörg (author)
Andlauer, Till (author)
Fischer, Andre (author)
Bermpohl, Felix (author)
Kraft, Vivien (author)
Matura, Silke (author)
Gryaznova, Anna (author)
Falkenberg, Irina (author)
Yildiz, Cüneyt (author)
Kircher, Tilo (author)
Schmidt, Julia (author)
Koch, Marius (author)
Gade, Katrin (author)
Trost, Sarah (author)
Haußleiter, Ida (author)
Lambert, Martin (author)
Rohenkohl, Anja C (author)
Kraft, Vivien (author)
Grof, Paul (author)
Hashimoto, Ryota (author)
Hauser, Joanna (author)
Herms, Stefan (author)
Hoffmann, Per (author)
Jiménez, Esther (author)
Kahn, Jean-Pierre (author)
Kassem, Layla (author)
Kuo, Po-Hsiu (author)
Kato, Tadafumi (author)
Kelsoe, John (author)
Kittel-Schneider, Sarah (author)
Ferensztajn-Rochowiak, Ewa (author)
König, Barbara (author)
Kusumi, Ichiro (author)
Laje, Gonzalo (author)
Landén, Mikael, 1966 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Lavebratt, Catharina (author)
Leboyer, Marion (author)
Leckband, Susan G (author)
Tortorella, Alfonso (author)
Manchia, Mirko (author)
Martinsson, Lina (author)
Karolinska Institutet
McCarthy, Michael (author)
McElroy, Susan L (author)
Colom, Francesc (author)
Mitjans, Marina (author)
Mondimore, Francis (author)
Monteleone, Palmiero (author)
Nievergelt, Caroline (author)
Nöthen, Markus (author)
Novak, Tomas (author)
O'Donovan, Claire (author)
Ozaki, Norio (author)
Pfennig, Andrea (author)
Pisanu, Claudia (author)
Potash, James (author)
Reif, Andreas (author)
Reininghaus, Eva (author)
Rouleau, Guy (author)
Rybakowski, Janusz K (author)
Schalling, Martin (author)
Schofield, Peter (author)
Schweizer, Barbara W (author)
Severino, Giovanni (author)
Shilling, Paul D (author)
Shimoda, Kazutaka (author)
Simhandl, Christian (author)
Slaney, Claire (author)
Squassina, Alessio (author)
Stamm, Thomas (author)
Stopkova, Pavla (author)
Maj, Mario (author)
Turecki, Gustavo (author)
Vieta, Eduard (author)
Veeh, Julia (author)
Witt, Stephanie (author)
Wright, Adam (author)
Zandi, Peter (author)
Mitchell, Philip (author)
Bauer, Michael (author)
Alda, Martin (author)
Rietschel, Marcella (author)
McMahon, Francis (author)
Schulze, Thomas G (author)
Millischer, Vincent (author)
Clark, Scott (author)
Baune, Bernhard (author)
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 (creator_code:org_t)
Research Square Platform LLC, 2023
2023
English.
In: Research square. - : Research Square Platform LLC.
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N=2,367) and replicated in the combined PsyCourse (N=89) and BipoLife (N=102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P<����������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

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By the author/editor
Amare, Azmeraw
Thalamuthu, Anbu ...
Schubert, Klaus ...
Fullerton, Janic ...
Ahmed, Muktar
Hartmann, Simon
show more...
Papiol, Sergi
Heilbronner, Urs
Degenhardt, Fran ...
Tekola-Ayele, Fa ...
Hou, Liping
Hsu, Yi-Hsiang
Shekhtman, Tatya ...
Adli, Mazda
Akula, Nirmala
Akiyama, Kazufum ...
Ardau, Raffaella
Arias, Bárbara
Aubry, Jean-Mich ...
Backlund, Lena
Bhattacharjee, A ...
Bellivier, Frank
Benabarre, Anton ...
Bengesser, Susan ...
Biernacka, Joann ...
Birner, Armin
Marie-Claire, Cy ...
Cervantes, Pablo
Chen, Hsi-Chung
Chillotti, Cater ...
Cichon, Sven
Cruceanu, Cristi ...
Czerski, Piotr
Dalkner, Nina
Zompo, Maria Del
DePaulo, J Raymo ...
Etain, Bruno
Jamain, Stéphane
Falkai, Peter
Forstner, Andrea ...
Frisén, Louise
Frye, Mark
Gard, Sébastien
Garnham, Julie
Goes, Fernando
Grigoroiu-Serban ...
Fallgatter, Andr ...
Stegmaier, Sophi ...
Ethofer, Thomas
Biere, Silvia
Petrova, Kristiy ...
Schuster, Ceylan
Adorjan, Kristin ...
Budde, Monika
Heilbronner, Mar ...
Kalman, Janos
Kohshour, Mojtab ...
Reich-Erkelenz, ...
Schaupp, Sabrina
Schulte, Eva
Senner, Fanny
Vogl, Thomas
Anghelescu, Ion- ...
Arolt, Volker
Dannlowski, Udo
Dietrich, Detlef ...
Figge, Christian
Jäger, Markus
Lang, Fabian
Juckel, Georg
Spitzer, Carsten
Reimer, Jens
Schmauß, Max
Schmitt, Andrea
Konrad, Carsten
von Hagen, Marti ...
Wiltfang, Jens
Zimmermann, Jörg
Andlauer, Till
Fischer, Andre
Bermpohl, Felix
Kraft, Vivien
Matura, Silke
Gryaznova, Anna
Falkenberg, Irin ...
Yildiz, Cüneyt
Kircher, Tilo
Schmidt, Julia
Koch, Marius
Gade, Katrin
Trost, Sarah
Haußleiter, Ida
Lambert, Martin
Rohenkohl, Anja ...
Grof, Paul
Hashimoto, Ryota
Hauser, Joanna
Herms, Stefan
Hoffmann, Per
Jiménez, Esther
Kahn, Jean-Pierr ...
Kassem, Layla
Kuo, Po-Hsiu
Kato, Tadafumi
Kelsoe, John
Kittel-Schneider ...
Ferensztajn-Roch ...
König, Barbara
Kusumi, Ichiro
Laje, Gonzalo
Landén, Mikael, ...
Lavebratt, Catha ...
Leboyer, Marion
Leckband, Susan ...
Tortorella, Alfo ...
Manchia, Mirko
Martinsson, Lina
McCarthy, Michae ...
McElroy, Susan L
Colom, Francesc
Mitjans, Marina
Mondimore, Franc ...
Monteleone, Palm ...
Nievergelt, Caro ...
Nöthen, Markus
Novak, Tomas
O'Donovan, Clair ...
Ozaki, Norio
Pfennig, Andrea
Pisanu, Claudia
Potash, James
Reif, Andreas
Reininghaus, Eva
Rouleau, Guy
Rybakowski, Janu ...
Schalling, Marti ...
Schofield, Peter
Schweizer, Barba ...
Severino, Giovan ...
Shilling, Paul D
Shimoda, Kazutak ...
Simhandl, Christ ...
Slaney, Claire
Squassina, Aless ...
Stamm, Thomas
Stopkova, Pavla
Maj, Mario
Turecki, Gustavo
Vieta, Eduard
Veeh, Julia
Witt, Stephanie
Wright, Adam
Zandi, Peter
Mitchell, Philip
Bauer, Michael
Alda, Martin
Rietschel, Marce ...
McMahon, Francis
Schulze, Thomas ...
Millischer, Vinc ...
Clark, Scott
Baune, Bernhard
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Psychiatry
Articles in the publication
By the university
University of Gothenburg
Karolinska Institutet

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