Predicting Circulating CA125 Levels among Healthy Premenopausal Women

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Predicting Circulating CA125 Levels among Healthy Premenopausal Women

Sasamoto, Naoko (författare): Harvard University,Brigham and Women's Hospital / Harvard Medical School

Babic, Ana (författare): Brigham and Women's Hospital / Harvard Medical School,Harvard University,Dana-Farber Cancer Institute

Rosner, Bernard A. (författare): Harvard University,Brigham and Women's Hospital / Harvard Medical School

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Fortner, Renee T. (författare): German Cancer Research Centre

Vitonis, Allison F. (författare): Brigham and Women's Hospital / Harvard Medical School

Yamamoto, Hidemi (författare): Brigham and Women's Hospital / Harvard Medical School

Fichorova, Raina N. (författare): Harvard University,Brigham and Women's Hospital / Harvard Medical School

Tjonneland, Anne (författare): Danish Cancer Society

Hansen, Louise (författare): Danish Cancer Society

Overvad, Kim (författare): Aarhus University

Kvaskoff, Marina (författare): University of Paris-Saclay

Fournier, Agnes (författare): University of Paris-Saclay

Mancini, Francesca Romana (författare): University of Paris-Saclay

Boeing, Heiner (författare): German Institute of Human Nutrition

Trichopoulou, Antonia (författare): National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens

Peppa, Eleni (författare): Hellenic Health Foundation, Athens

Karakatsani, Anna (författare): National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens

Palli, Domenico (författare): Institute for Cancer Research, Prevention and Clinical Network (ISPRO)

Pala, Valeria (författare): Istituto Nazionale dei Tumori

Mattiello, Amalia (författare): University of Naples Federico II

Tumino, Rosario (författare): Civic and M.P Arezzo Hospital

Grasso, Chiara C. (författare): University of Turin

Onland-Moret, N. Charlotte (författare): University Medical Center Utrecht

Weiderpass, Elisabete (författare): Karolinska Institutet,University of Helsinki,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø

Ramon Quiros, J. (författare): Public Health Directorate

Lujan-Barroso, Leila (författare): Bellvitge University Hospital-IDIBELL

Rodriguez-Barranco, Miguel (författare): CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)

Colorado-Yohar, Sandra (författare): University of Antioquia,Murcia Regional Health Council

Barricarte, Aurelio (författare): Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)

Dorronsoro, Miren (författare): CIBER Epidemiology and Public Health (CIBERESP)

Idahl, Annika, 1965- (författare): Umeå University,Umeå universitet,Obstetrik och gynekologi,Näringsforskning

Lundin, Eva (författare): Umeå University,Umeå universitet,Patologi

Sartor, Hanna (författare): Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital

Khaw, Kay-Tee (författare): University of Cambridge

Key, Timothy J. (författare): University of Oxford

Muller, David (författare): Imperial College London

Riboli, Elio (författare): International Agency for Research on Cancer, World Health Organization

Gunter, Marc J. (författare): International Agency for Research on Cancer, World Health Organization

Dossus, Laure (författare): International Agency for Research on Cancer, World Health Organization

Kaaks, Rudolf (författare): German Cancer Research Centre

Cramer, Daniel W. (författare): Harvard University,Brigham and Women's Hospital / Harvard Medical School

Tworoger, Shelley S. (författare): H. Lee Moffitt Cancer Center & Research Institute

Terry, Kathryn L. (författare): Brigham and Women's Hospital / Harvard Medical School,Harvard University

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(creator_code:org_t)

American Association for Cancer Research (AACR), 2019
2019
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 28:6, s. 1076-1085

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; http://kipublication...; visa färre...

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Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (>= 35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Results: The final linear CA125 prediction model included age, race, tubal ligation, endometriosis, menstrual phase at blood draw, and fibroids, which explained 7% of the total variance of CA125. The correlation between observed and predicted CA125 levels based on the abridged model (including age, race, and menstrual phase at blood draw) had similar correlation coefficients in NEC (r = 0.22) and in EPIC (r = 0.22). The dichotomous CA125 prediction model included age, tubal ligation, endometriosis, prior personal cancer diagnosis, family history of ovarian cancer, number of miscarriages, menstrual phase at blood draw, and smoking status with AUC of 0.83. The abridged dichotomous model (including age, number of miscarriages, menstrual phase at blood draw, and smoking status) showed similar AUCs in NEC (0.73) and in EPIC (0.78). Conclusions: We identified a combination of factors associated with CA125 levels in premenopausal women. Impact: Our model could be valuable in identifying healthy women likely to have elevated CA125 and consequently improve its specificity for ovarian cancer screening.

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Cancer Epidemiology, Biomarkers and Prevention (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Sasamoto, Naoko; Babic, Ana; Rosner, Bernard ...; Fortner, Renee T ...; Vitonis, Allison ...; Yamamoto, Hidemi; visa fler...; Fichorova, Raina ...; Tjonneland, Anne; Hansen, Louise; Overvad, Kim; Kvaskoff, Marina; Fournier, Agnes; Mancini, Frances ...; Boeing, Heiner; Trichopoulou, An ...; Peppa, Eleni; Karakatsani, Ann ...; Palli, Domenico; Pala, Valeria; Mattiello, Amali ...; Tumino, Rosario; Grasso, Chiara C ...; Onland-Moret, N. ...; Weiderpass, Elis ...; Ramon Quiros, J.; Lujan-Barroso, L ...; Rodriguez-Barran ...; Colorado-Yohar, ...; Barricarte, Aure ...; Dorronsoro, Mire ...; Idahl, Annika, 1 ...; Lundin, Eva; Sartor, Hanna; Khaw, Kay-Tee; Key, Timothy J.; Muller, David; Riboli, Elio; Gunter, Marc J.; Dossus, Laure; Kaaks, Rudolf; Cramer, Daniel W ...; Tworoger, Shelle ...; Terry, Kathryn L ...; visa färre...

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Av lärosätet: Umeå universitet; Lunds universitet; Karolinska Institutet

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Predicting Circulating CA125 Levels among Healthy Premenopausal Women

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