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Investigating relia...
Investigating reliable amyloid accumulation in Centiloids : Results from the AMYPAD Prognostic and Natural History Study
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- Bollack, Ariane (author)
- University College London
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- Collij, Lyduine E. (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Garcia, David Vallez (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Shekari, Mahnaz (author)
- Pompeu Fabra University,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer
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- Altomare, Daniele (author)
- University of Brescia
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- Payoux, Pierre (author)
- University of Toulouse,Toulouse University Hospital
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- Dubois, Bruno (author)
- Paris-Sorbonne University
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- Grau-Rivera, Oriol (author)
- Pasqual Maragall Foundation for Research on Alzheimer
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- Boada, Mercè (author)
- International University of Catalonia,CIBER Enfermedades Neurodegenerativas (CIBERNED)
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- Marquié, Marta (author)
- International University of Catalonia,CIBER Enfermedades Neurodegenerativas (CIBERNED)
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- Nordberg, Agneta (author)
- Karolinska Institute,Karolinska University Hospital
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- Walker, Zuzana (author)
- University College London
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- Scheltens, Philip (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Schöll, Michael (author)
- University of Gothenburg,Sahlgrenska University Hospital,University College London,Sahlgrenska Academy
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- Wolz, Robin (author)
- IXICO Plc
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- Schott, Jonathan M. (author)
- University College London
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- Gismondi, Rossella (author)
- Life Molecular Imaging GmbH
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- Stephens, Andrew (author)
- Life Molecular Imaging GmbH
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- Buckley, Christopher (author)
- GE Healthcare, UK
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- Frisoni, Giovanni B. (author)
- University of Brescia
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- Hanseeuw, Bernard (author)
- Saint-Luc University Hospital,Massachusetts General Hospital
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- Visser, Pieter Jelle (author)
- Karolinska Institute,Amsterdam UMC - Vrije Universiteit Amsterdam,Maastricht University
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- Vandenberghe, Rik (author)
- Catholic University of Leuven
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- Drzezga, Alexander (author)
- University Hospital of Cologne,Jülich Research Centre,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Yaqub, Maqsood (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Boellaard, Ronald (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,University Medical Center Groningen
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- Gispert, Juan Domingo (author)
- Pompeu Fabra University,CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),Pasqual Maragall Foundation for Research on Alzheimer
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- Markiewicz, Pawel (author)
- London South Bank University,University College London
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- Cash, David M. (author)
- University College London
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- Farrar, Gill (author)
- GE Healthcare, UK
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- Barkhof, Frederik (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam,University College London
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(creator_code:org_t)
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- 2024
- 2024
- English.
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In: Alzheimer's and Dementia. - 1552-5260.
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- INTRODUCTION: To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations. METHODS: A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease–Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid-PET were included. A normative strategy was used to define reliable accumulation by estimating the 95th percentile of longitudinal measurements in sub-populations (NPNHS = 101/750, NInsight46 = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision-recall analyses. Accumulation rates were examined using linear mixed-effect models. RESULTS: Reliable accumulation in the PNHS was estimated to occur at >3.0 CL/year. Baseline CL of 16 [12,19] best predicted future Aβ-accumulators. Rates of amyloid accumulation were tracer-independent, lower for APOE ε4 non-carriers, and for subjects with higher levels of education. DISCUSSION: Our results support a 12–20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Alzheimer's
- amyloid
- Centiloid
- longitudinal PET
- quantification
- reliable accumulation
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Bollack, Ariane
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Collij, Lyduine ...
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Garcia, David Va ...
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Shekari, Mahnaz
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Altomare, Daniel ...
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Payoux, Pierre
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show more...
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Dubois, Bruno
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Grau-Rivera, Ori ...
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Boada, Mercè
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Marquié, Marta
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Nordberg, Agneta
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Walker, Zuzana
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Scheltens, Phili ...
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Schöll, Michael
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Wolz, Robin
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Schott, Jonathan ...
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Gismondi, Rossel ...
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Stephens, Andrew
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Buckley, Christo ...
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Frisoni, Giovann ...
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Hanseeuw, Bernar ...
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Visser, Pieter J ...
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Vandenberghe, Ri ...
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Drzezga, Alexand ...
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Yaqub, Maqsood
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Boellaard, Ronal ...
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Gispert, Juan Do ...
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Markiewicz, Pawe ...
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Cash, David M.
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Farrar, Gill
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Barkhof, Frederi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University