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Investigating reliable amyloid accumulation in Centiloids : Results from the AMYPAD Prognostic and Natural History Study

Bollack, Ariane (author)
University College London
Collij, Lyduine E. (author)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Amsterdam UMC - Vrije Universiteit Amsterdam
Garcia, David Vallez (author)
Amsterdam UMC - Vrije Universiteit Amsterdam
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Shekari, Mahnaz (author)
Pompeu Fabra University,Hospital del Mar Medical Research Institute,Pasqual Maragall Foundation for Research on Alzheimer
Altomare, Daniele (author)
University of Brescia
Payoux, Pierre (author)
University of Toulouse,Toulouse University Hospital
Dubois, Bruno (author)
Paris-Sorbonne University
Grau-Rivera, Oriol (author)
Pasqual Maragall Foundation for Research on Alzheimer
Boada, Mercè (author)
International University of Catalonia,CIBER Enfermedades Neurodegenerativas (CIBERNED)
Marquié, Marta (author)
International University of Catalonia,CIBER Enfermedades Neurodegenerativas (CIBERNED)
Nordberg, Agneta (author)
Karolinska Institute,Karolinska University Hospital
Walker, Zuzana (author)
University College London
Scheltens, Philip (author)
Amsterdam UMC - Vrije Universiteit Amsterdam
Schöll, Michael (author)
University of Gothenburg,Sahlgrenska University Hospital,University College London,Sahlgrenska Academy
Wolz, Robin (author)
IXICO Plc
Schott, Jonathan M. (author)
University College London
Gismondi, Rossella (author)
Life Molecular Imaging GmbH
Stephens, Andrew (author)
Life Molecular Imaging GmbH
Buckley, Christopher (author)
GE Healthcare, UK
Frisoni, Giovanni B. (author)
University of Brescia
Hanseeuw, Bernard (author)
Saint-Luc University Hospital,Massachusetts General Hospital
Visser, Pieter Jelle (author)
Karolinska Institute,Amsterdam UMC - Vrije Universiteit Amsterdam,Maastricht University
Vandenberghe, Rik (author)
Catholic University of Leuven
Drzezga, Alexander (author)
University Hospital of Cologne,Jülich Research Centre,German Center for Neurodegenerative Diseases (DZNE), Bonn
Yaqub, Maqsood (author)
Amsterdam UMC - Vrije Universiteit Amsterdam
Boellaard, Ronald (author)
Amsterdam UMC - Vrije Universiteit Amsterdam,University Medical Center Groningen
Gispert, Juan Domingo (author)
Pompeu Fabra University,CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),Pasqual Maragall Foundation for Research on Alzheimer
Markiewicz, Pawel (author)
London South Bank University,University College London
Cash, David M. (author)
University College London
Farrar, Gill (author)
GE Healthcare, UK
Barkhof, Frederik (author)
Amsterdam UMC - Vrije Universiteit Amsterdam,University College London
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 (creator_code:org_t)
 
2024
2024
English.
In: Alzheimer's and Dementia. - 1552-5260.
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • INTRODUCTION: To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations. METHODS: A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease–Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid-PET were included. A normative strategy was used to define reliable accumulation by estimating the 95th percentile of longitudinal measurements in sub-populations (NPNHS = 101/750, NInsight46 = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision-recall analyses. Accumulation rates were examined using linear mixed-effect models. RESULTS: Reliable accumulation in the PNHS was estimated to occur at >3.0 CL/year. Baseline CL of 16 [12,19] best predicted future Aβ-accumulators. Rates of amyloid accumulation were tracer-independent, lower for APOE ε4 non-carriers, and for subjects with higher levels of education. DISCUSSION: Our results support a 12–20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Geriatrics (hsv//eng)

Keyword

Alzheimer's
amyloid
Centiloid
longitudinal PET
quantification
reliable accumulation

Publication and Content Type

art (subject category)
ref (subject category)

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