Association of Autoimmune Addison's Disease with Alleles of STAT4 and GATA3 in European Cohorts

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Sökning: onr:"swepub:oai:gup.ub.gu.se/197696" > Association of Auto...

1 av 1
Föregående post
Nästa post
Till träfflistan

Association of Autoimmune Addison's Disease with Alleles of STAT4 and GATA3 in European Cohorts

Lobell, Anna (författare): Uppsala universitet,Autoimmunitet,Newcastle University, England,Uppsala University, Sweden

Macarthur, K. D. R. (författare): Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom,Newcastle University, England

Gan, E. H. (författare): Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom,Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway,Newcastle University, England

visa fler...

Baggott, L. E. (författare): Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom,Newcastle University, England

Bensing, Sophie (författare): Uppsala universitet,Karolinska Institutet,Autoimmunitet,University of Bergen, Norway,Uppsala University, Sweden Karolinska Institute, Sweden

Skinningsrud, B. (författare): Oslo University Hospital, Norway University of Oslo, Norway

Platt, H. (författare): CIGMR, Institute of Population Health, University of Manchester, Manchester, United Kingdom,University of Manchester, England

Short, A. (författare): University of Manchester, England

Lobell, A. (författare): Karolinska Institutet

Kämpe, Olle (författare): Uppsala universitet,Karolinska Institutet,Autoimmunitet,Uppsala University, Sweden

Bensing, S. (författare)

Betterle, C. (författare): Department of Medicine, University of Padua School of Medicine, Padua, Italy

Kasperlik-Zaluska, A. (författare): Department of Endocrinology, Center for Postgraduate Medical Education, Warsaw, Poland,Medical Centre Postgrad Educ, Poland

Zurawek, M. (författare): Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

Fichna, M. (författare): Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

Kockum, I. (författare): Karolinska Institutet,Karolinska Institute, Sweden Karolinska Institute, Sweden

Eriksson, G. N. (författare): Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

Ekwall, Olov, 1968 (författare): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Wahlberg, Jeanette, 1969- (författare): Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Endokrinmedicinska kliniken

Dahlqvist, Per (författare): Umeå universitet,Medicin,Umeå University, Sweden

Hulting, A. L. (författare): Karolinska Institutet, Stockholm, Sweden

Penna-Martinez, M. (författare): Department Medicine (Division Endocrinology), University Hospital Frankfurt, Goethe-University, Frankfurt, Germany,Goethe University of Frankfurt, Germany

Meyer, G. (författare): Department Medicine (Division Endocrinology), University Hospital Frankfurt, Goethe-University, Frankfurt, Germany,Goethe University of Frankfurt, Germany

Kahles, H. (författare): Department Medicine (Division Endocrinology), University Hospital Frankfurt, Goethe-University, Frankfurt, Germany,Goethe University of Frankfurt, Germany

Badenhoop, K. (författare): Department Medicine (Division Endocrinology), University Hospital Frankfurt, Goethe-University, Frankfurt, Germany,Goethe University of Frankfurt, Germany

Hahner, S. (författare): University Hospital Wuerzburg (Department of Medicine, Endocrinology and Diabetology), Wuerzburg, Germany,Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom,Newcastle University, England

Quinkler, M. (författare): Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Berlin, Germany

Falorni, A. (författare): Department of Internal Medicine, University of Perugia, Perugia, Italy

Phipps-Green, A. (författare): Department of Biochemistry, University of Otago, Otago, New Zealand

Merriman, T. R. (författare): Department of Biochemistry, University of Otago, Otago, New Zealand

Ollier, W. (författare): CIGMR, Institute of Population Health, University of Manchester, Manchester, United Kingdom,University of Manchester, England

Cordell, H. J. (författare): Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom,Newcastle University, England

Undlien, D. (författare): Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; University of Oslo, Oslo, Norway

Czarnocka, B. (författare): Department of Biochemistry and Molecular Biology, Center for Postgraduate Medical Education, Warsaw, Poland,Medical Centre Postgrad Educ, Poland

Husebye, E. (författare)

Pearce, S. H. S. (författare)

visa färre...

(creator_code:org_t)

2014-03-10
2014
Engelska.
Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 9:3

Relaterad länk:: https://journals.plo...; visa fler...; https://doi.org/10.1...; https://umu.diva-por... (primary) (Raw object); https://uu.diva-port... (primary) (Raw object); https://liu.diva-por... (primary) (Raw object); https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; http://kipublication...; https://urn.kb.se/re...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background: Gene variants known to contribute to Autoimmune Addison's disease (AAD) susceptibility include those at the MHC, MICA, CIITA, CTLA4, PTPN22, CYP27B1, NLRP-1 and CD274 loci. The majority of the genetic component to disease susceptibility has yet to be accounted for. Aim: To investigate the role of 19 candidate genes in AAD susceptibility in six European case-control cohorts. Methods: A sequential association study design was employed with genotyping using Sequenom iPlex technology. In phase one, 85 SNPs in 19 genes were genotyped in UK and Norwegian AAD cohorts (691 AAD, 715 controls). In phase two, 21 SNPs in 11 genes were genotyped in German, Swedish, Italian and Polish cohorts (1264 AAD, 1221 controls). In phase three, to explore association of GATA3 polymorphisms with AAD and to determine if this association extended to other autoimmune conditions, 15 SNPs in GATA3 were studied in UK and Norwegian AAD cohorts, 1195 type 1 diabetes patients from Norway, 650 rheumatoid arthritis patients from New Zealand and in 283 UK Graves' disease patients. Meta-analysis was used to compare genotype frequencies between the participating centres, allowing for heterogeneity. Results: We report significant association with alleles of two STAT4 markers in AAD cohorts (rs4274624: P = 0.00016; rs10931481: P = 0.0007). In addition, nominal association of AAD with alleles at GATA3 was found in 3 patient cohorts and supported by meta-analysis. Association of AAD with CYP27B1 alleles was also confirmed, which replicates previous published data. Finally, nominal association was found at SNPs in both the NF-kappa B1 and IL23A genes in the UK and Italian cohorts respectively. Conclusions: Variants in the STAT4 gene, previously associated with other autoimmune conditions, confer susceptibility to AAD. Additionally, we report association of GATA3 variants with AAD: this adds to the recent report of association of GATA3 variants with rheumatoid arthritis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

Nyckelord

rheumatoid-arthritis
graves-disease
hashimotos-thyroiditis
identical-twins
population
gene
susceptibility
polymorphism
haplotype
prevalence
MEDICINE

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Plos One (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reumatologi och ...

Artiklar i publikationen: Plos One

Av lärosätet: Göteborgs universitet; Örebro universitet; Umeå universitet; Karolinska Institutet; Uppsala universitet; Linköpings universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se