SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Berndt Sonja I)
 

Sökning: WFRF:(Berndt Sonja I) > Epidemiologic facto...

Epidemiologic factors in relation to colorectal cancer risk and survival by genotoxic colibactin mutational signature

Thomas, Claire E. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Georgeson, Peter (författare)
Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Australia; University of Melbourne Centre for Cancer Research, University of Melbourne, Parkville, Australia
Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
visa fler...
Steinfelder, Robert S. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Buchanan, Daniel D. (författare)
Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Parkville, Australia; University of Melbourne Centre for Cancer Research, University of Melbourne, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia
Song, Mingyang (författare)
Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Harrison, Tabitha A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Um, Caroline Y. (författare)
Department of Population Science, American Cancer Society, Atlanta, Georgia
Hullar, Meredith A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Jenkins, Mark A. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Lynch, Brigid M. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
Melaku, Yohannes Adama (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; College of Medicine and Public Health, Flinders University, SA, Adelaide, Australia
Huyghe, Jeroen R. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Aglago, Elom K. (författare)
Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, Liberia
Boardman, Lisa A. (författare)
Gastroenterology and Hepatology, Mayo Clinic, MN, Rochester, United States
Campbell, Peter T. (författare)
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
Cao, Yin (författare)
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, MO, St Louis, United States; Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, MO, St. Louis, United States; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, MO, St. Louis, United States
Chan, Andrew T. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Drew, David A. (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
Figueiredo, Jane C. (författare)
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
French, Amy J. (författare)
Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
Giannakis, Marios (författare)
Department of Medical Oncology, Dana-Farber Cancer Institute, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States
Goode, Ellen L. (författare)
Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, MN, Rochester, United States
Gruber, Stephen B. (författare)
Department of Medical Oncology and Therapeutics Research and Center for Precision Medicine, City of Hope National Medical Center, Duarte, California
Gsur, Andrea (författare)
Center for Cancer Research, Medical University of Vienna, Vienna, Austria
Gunter, Marc J. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, United Kingdom
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
Huang, Wen-Yi (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, Liberia
Moreno, Victor (författare)
Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain
Murphy, Neil (författare)
Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
Newcomb, Polly A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Newton, Christina C. (författare)
Department of Population Science, American Cancer Society, Atlanta, Georgia
Nowak, Jonathan A. (författare)
Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Pathology, Dana-Farber Cancer Institute, MA, Boston, United States
Obón-Santacana, Mireia (författare)
Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Ogino, Shuji (författare)
Broad Institute of MIT and Harvard, MA, Cambridge, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Sun, Wei (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Toland, Amanda E. (författare)
Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, Ohio State University, OH, Columbus, United States
Trinh, Quang M. (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Ugai, Tomotaka (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Zaidi, Syed H. (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Phipps, Amanda I. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
visa färre...
 (creator_code:org_t)
American Association For Cancer Research (AACR), 2024
2024
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association For Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 33:4, s. 534-546
Relaterad länk:
https://urn.kb.se/re...
visa fler...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: The genotoxin colibactin causes a tumor single-base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors' association with colorectal cancer risk and survival differs by SBS88.METHODS: Within the Genetic Epidemiology of Colorectal Cancer Consortium and Colon Cancer Family Registry, we measured SBS88 in 4,308 microsatellite stable/microsatellite instability low tumors. Associations of epidemiologic factors with colorectal cancer risk by SBS88 were assessed using multinomial regression (N = 4,308 cases, 14,192 controls; cohort-only cases N = 1,911), and with colorectal cancer-specific survival using Cox proportional hazards regression (N = 3,465 cases).RESULTS: 392 (9%) tumors were SBS88 positive. Among all cases, the highest quartile of fruit intake was associated with lower risk of SBS88-positive colorectal cancer than SBS88-negative colorectal cancer [odds ratio (OR) = 0.53, 95% confidence interval (CI) 0.37-0.76; OR = 0.75, 95% CI 0.66-0.85, respectively, Pheterogeneity = 0.047]. Among cohort studies, associations of body mass index (BMI), alcohol, and fruit intake with colorectal cancer risk differed by SBS88. BMI ≥30 kg/m2 was associated with worse colorectal cancer-specific survival among those SBS88-positive [hazard ratio (HR) = 3.40, 95% CI 1.47-7.84], but not among those SBS88-negative (HR = 0.97, 95% CI 0.78-1.21, Pheterogeneity = 0.066).CONCLUSIONS: Most epidemiologic factors did not differ by SBS88 for colorectal cancer risk or survival. Higher BMI may be associated with worse colorectal cancer-specific survival among those SBS88-positive; however, validation is needed in samples with whole-genome or whole-exome sequencing available.IMPACT: This study highlights the importance of identification of tumor phenotypes related to colorectal cancer and understanding potential heterogeneity for risk and survival.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy