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Genome-wide associa...
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
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- Melin, Beatrice S. (author)
- Umeå universitet,Institutionen för strålningsvetenskaper
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Barnholtz-Sloan, Jill S. (author)
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Wrensch, Margaret R. (author)
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show more...
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Johansen, Christoffer (author)
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Il'yasova, Dora (author)
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Kinnersley, Ben (author)
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Ostrom, Quinn T. (author)
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Labreche, Karim (author)
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Chen, Yanwen (author)
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Armstrong, Georgina (author)
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Liu, Yanhong (author)
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Eckel-Passow, Jeanette E. (author)
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Decker, Paul A. (author)
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Labussiere, Marianne (author)
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Idbaih, Ahmed (author)
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Hoang-Xuan, Khe (author)
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Di Stefano, Anna-Luisa (author)
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Mokhtari, Karima (author)
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Delattre, Jean-Yves (author)
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Broderick, Peter (author)
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Galan, Pilar (author)
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Gousias, Konstantinos (author)
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Schramm, Johannes (author)
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Schoemaker, Minouk J. (author)
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Fleming, Sarah J. (author)
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Herms, Stefan (author)
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Heilmann, Stefanie (author)
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Noethen, Markus M. (author)
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Wichmann, Heinz-Erich (author)
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Schreiber, Stefan (author)
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Swerdlow, Anthony (author)
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Lathrop, Mark (author)
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Simon, Matthias (author)
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Sanson, Marc (author)
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- Andersson, Ulrika (author)
- Umeå universitet,Institutionen för strålningsvetenskaper
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Rajaraman, Preetha (author)
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Chanock, Stephen (author)
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Linet, Martha (author)
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Wang, Zhaoming (author)
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Yeager, Meredith (author)
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Wiencke, John K. (author)
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Hansen, Helen (author)
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Mccoy, Lucie (author)
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Rice, Terri (author)
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Kosel, Matthew L. (author)
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Sicotte, Hugues (author)
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Amos, Christopher I. (author)
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Bernstein, Jonine L. (author)
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Davis, Faith (author)
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Lachance, Dan (author)
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Lau, Ching (author)
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Merrell, Ryan T. (author)
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Shildkraut, Joellen (author)
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Ali-Osman, Francis (author)
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Sadetzki, Siegal (author)
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Scheurer, Michael (author)
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Shete, Sanjay (author)
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Lai, Rose K. (author)
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Claus, Elizabeth B. (author)
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Olson, Sara H. (author)
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Jenkins, Robert B. (author)
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Houlston, Richard S. (author)
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Bondy, Melissa L. (author)
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(creator_code:org_t)
- 2017-03-27
- 2017
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:5, s. 789-794
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 x 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 x 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 x 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 x 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 x 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 x 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 x 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 x 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 x 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 x 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 x 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 x 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 x 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Melin, Beatrice ...
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Barnholtz-Sloan, ...
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Wrensch, Margare ...
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Johansen, Christ ...
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Il'yasova, Dora
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Kinnersley, Ben
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show more...
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Ostrom, Quinn T.
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Labreche, Karim
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Chen, Yanwen
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Armstrong, Georg ...
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Liu, Yanhong
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Eckel-Passow, Je ...
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Decker, Paul A.
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Labussiere, Mari ...
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Idbaih, Ahmed
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Hoang-Xuan, Khe
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Di Stefano, Anna ...
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Mokhtari, Karima
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Delattre, Jean-Y ...
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Broderick, Peter
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Galan, Pilar
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Gousias, Konstan ...
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Schramm, Johanne ...
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Schoemaker, Mino ...
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Fleming, Sarah J ...
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Herms, Stefan
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Heilmann, Stefan ...
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Noethen, Markus ...
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Wichmann, Heinz- ...
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Schreiber, Stefa ...
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Swerdlow, Anthon ...
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Lathrop, Mark
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Simon, Matthias
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Sanson, Marc
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Andersson, Ulrik ...
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Rajaraman, Preet ...
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Chanock, Stephen
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Linet, Martha
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Wang, Zhaoming
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Yeager, Meredith
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Wiencke, John K.
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Hansen, Helen
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Mccoy, Lucie
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Rice, Terri
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Kosel, Matthew L ...
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Sicotte, Hugues
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Amos, Christophe ...
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Bernstein, Jonin ...
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Davis, Faith
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Lachance, Dan
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Lau, Ching
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Merrell, Ryan T.
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Shildkraut, Joel ...
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Ali-Osman, Franc ...
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Sadetzki, Siegal
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Scheurer, Michae ...
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Shete, Sanjay
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Lai, Rose K.
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Claus, Elizabeth ...
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Olson, Sara H.
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Jenkins, Robert ...
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Houlston, Richar ...
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Bondy, Melissa L ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Umeå University