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Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of US adults

Holliday, Katelyn M. (författare)
Duke Univ, Sch Med, Dept Family Med & Community Hlth, Durham, NC USA.;Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
Gondalia, Rahul (författare)
Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
Baldassari, Antoine (författare)
Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
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Justice, Anne E. (författare)
Geisinger Hlth Syst, Danville, PA USA.
Stewart, James D. (författare)
Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
Liao, Duanping (författare)
Penn State Univ, Dept Publ Hlth Sci, Coll Med, Div Epidemiol, Hershey, PA USA.
Yanosky, Jeff D. (författare)
Penn State Univ, Dept Publ Hlth Sci, Coll Med, Div Epidemiol, Hershey, PA USA.
Jordahl, Kristina M. (författare)
Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA.
Bhatti, Parveen (författare)
BC Canc, Canc Control Res, Vancouver, BC, Canada.
Assimes, Themistocles L. (författare)
Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA.
Pankow, James S. (författare)
Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
Guan, Weihua (författare)
Univ Minnesota, Div Biostat, Minneapolis, MN USA.
Fornage, Myriam (författare)
Univ Texas Hlth Sci Ctr Houston, Brown Fdn, Inst Mol Med, McGovern Med Sch, Houston, TX 77030 USA.;Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Houston, TX 77030 USA.
Bressler, Jan (författare)
Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Houston, TX 77030 USA.
North, Kari E. (författare)
Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.
Conneely, Karen N. (författare)
Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA USA.
Li, Yun (författare)
Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.;Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.;Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27515 USA.
Hou, Lifang (författare)
Northwestern Univ Chicago, Feinberg Sch Med, Dept Prevent Med, Evanston, IL USA.;Northwestern Univ Chicago, Ctr Populat Epigenet, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Evanston, IL USA.
Vokonas, Pantel S. (författare)
Boston Univ, Sch Med, VA Normat Aging Study, VA Boston Healthcare Syst, Boston, MA 02118 USA.;Boston Univ, Sch Publ Hlth, VA Normat Aging Study, VA Boston Healthcare Syst, Boston, MA 02118 USA.
Ward-Caviness, Cavin K. (författare)
Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, 104 Mason Farm Rd, Chapel Hill, NC 27514 USA.
Wilson, Rory (författare)
German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
Wolf, Kathrin (författare)
German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
Waldenberger, Melanie (författare)
German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
Cyrys, Josef (författare)
German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.
Peters, Annette (författare)
German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Med Fac, Inst Med Informat Proc Biometry & Epidemiol, Munich, Germany.
Boezen, H. Marike (författare)
Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Groningen, Netherlands.
Vonk, Judith M. (författare)
Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Groningen, Netherlands.
Sayols-Baixeras, Sergi (författare)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Univ Pompeu Fabra, Hosp Mar, Cardiovasc Epidemiol & Genet Res Grp, Med Res Inst IMIM, Campus Mar, Barcelona, Spain.;Inst Salud Carlos III, MP Enfermedades Cardiovasc CIBERCV, Consorcio CIBER, Madrid, Spain.
Lee, Mikyeong (författare)
NIEHS, Epidemiol Branch, NIH, US Dept HHS, POB 12233, Res Triangle Pk, NC 27709 USA.
Baccarelli, Andrea A. (författare)
Columbia Univ, Dept Environm Hlth Sci, Lab Environm Epigenet, Mailman Sch Publ Hlth, New York, NY USA.;Columbia Univ, Dept Epidemiol, Lab Environm Epigenet, Mailman Sch Publ Hlth, New York, NY USA.
Whitsel, Eric A. (författare)
Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.;Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USA.
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Duke Univ, Sch Med, Dept Family Med & Community Hlth, Durham, NC USA;Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA. Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA. (creator_code:org_t)
Elsevier, 2022
2022
Engelska.
Ingår i: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 212
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Epigenetic mechanisms may underlie air pollution-health outcome associations. We estimated gaseous air pollutant-DNA methylation (DNAm) associations using twelve subpopulations within Women's Health Initiative (WHI) and Atherosclerosis Risk in Communities (ARIC) cohorts (n = 8397; mean age 61.3 years; 83% female; 46% African-American, 46% European-American, 8% Hispanic/Latino). We used geocoded participant address-specific mean ambient carbon monoxide (CO), nitrogen oxides (NO2; NOx), ozone (O-3), and sulfur dioxide (SO2) concentrations estimated over the 2-, 7-, 28-, and 365-day periods before collection of blood samples used to generate Illumina 450 k array leukocyte DNAm measurements. We estimated methylome-wide, subpopulation-and race/ethnicity-stratified pollutant-DNAm associations in multi-level, linear mixed-effects models adjusted for sociodemographic, behavioral, meteorological, and technical covariates. We combined stratum-specific estimates in inverse variance-weighted meta-analyses and characterized significant associations (false discovery rate; FDR<0.05) at Cytosine-phosphate-Guanine (CpG) sites without among-strata heterogeneity (P-Cochran's Q > 0.05). We attempted replication in the Cooperative Health Research in Region of Augsburg (KORA) study and Normative Aging Study (NAS). We observed a -0.3 (95% CI: -0.4, -0.2) unit decrease in percent DNAm per interquartile range (IQR, 7.3 ppb) increase in 28-day mean NO2 concentration at cg01885635 (chromosome 3; regulatory region 290 bp upstream from ZNF621; FDR = 0.03). At intragenic sites cg21849932 (chromosome 20; LIME1; intron 3) and cg05353869 (chromosome 11; KLHL35; exon 2), we observed a -0.3 (95% CI: -0.4, -0.2) unit decrease (FDR = 0.04) and a 1.2 (95% CI: 0.7, 1.7) unit increase (FDR = 0.04), respectively, in percent DNAm per IQR (17.6 ppb) increase in 7-day mean ozone concentration. Results were not fully replicated in KORA and NAS. We identified three CpG sites potentially susceptible to gaseous air pollution-induced DNAm changes near genes relevant for cardiovascular and lung disease. Further harmonized investigations with a range of gaseous pollutants and averaging durations are needed to determine the effect of gaseous air pollutants on DNA methylation and ultimately gene expression.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)

Nyckelord

Air pollution
DNA methylation
Epigenetics
Epigenome-wide association study
Gaseous pollutants

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