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Sökning: onr:"swepub:oai:DiVA.org:uu-443195" > An integrated multi...

An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

Viborg Lindskrog, Sia (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
Prip, Frederik (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
Lamy, Philippe (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark,Aarhus University Hospital
visa fler...
Taber, Ann (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
Groeneveld, Clarice S. (författare)
Ligue Natl Canc, Cartes Identite Tumeurs CIT Program, Paris, France; Inst Curie, UMR144, Oncol Mol, Paris, France,Curie Institute, Paris,Ligue Nationale Contre le Cancer
Birkenkamp-Demtröder, Karin (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
Bjerggaard Jensen, Jørgen (författare)
Aarhus Univ, Dept Clin Med, Aarhus, Denmark; Aarhus Univ Hosp, Dept Urol, Aarhus N, Denmark,Aarhus University Hospital
Strandgaard, Trine (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
Nordentoft, Iver (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark,Aarhus University Hospital
Christensen, Emil (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
Sokac, Mateo (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
Birkbak, Nicolai J. (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
Maretty, Lasse (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
Hermann, Gregers G. (författare)
Univ Copenhagen, Herlev Hosp, Dept Urol, Copenhagen, Denmark,University of Copenhagen
Petersen, Astrid C. (författare)
Aalborg Univ Hosp, Dept Pathol, Aalborg, Denmark,Aalborg University Hospital
Weyerer, Veronika (författare)
Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Inst Pathol, Erlangen, Germany,University Hospital Erlangen
Grimm, Marc-Oliver (författare)
Jena Univ Hosp, Dept Urol, Jena, Germany,Universitätsklinikum Jena
Horstmann, Marcus (författare)
Jena Univ Hosp, Dept Urol, Jena, Germany; St Josephshosp, Dept Urol, Malteser Hosp, Krefeld, Germany,St. Josefs Hospital Uerdingen,Universitätsklinikum Jena
Sjödahl, Gottfrid (författare)
Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Genomiska analyser av urinblåscancer,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urology - urothelial cancer, Malmö,Lund University Research Groups,Urothelial Cancer Genomics,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Skane Univ Hosp, Dept Translat Med, Div Urol Res, Malmö, Sweden
Höglund, Mattias (författare)
Lund University,Lunds universitet,Genomiska analyser av urinblåscancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urothelial Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden
Steiniche, Torben (författare)
Aarhus Univ Hosp, Dept Pathol, Aarhus N, Denmark,Aarhus University Hospital
Mogensen, Karin (författare)
Univ Copenhagen, Herlev Hosp, Dept Urol, Copenhagen, Denmark,University of Copenhagen
de Reyniès, Aurélien (författare)
Ligue Natl Canc, Cartes Identite Tumeurs CIT Program, Paris, France,Ligue Nationale Contre le Cancer
Nawroth, Roman (författare)
Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany
Jordan, Brian (författare)
Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine
Lin, Xiaoqi (författare)
Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine
Dragicevic, Dejan (författare)
Univ Belgrade, Fac Med, Clin Ctr Serbia, Clin Urol, Belgrade, Serbia,University of Belgrade,Leeds School of Medicine,Pennsylvania State University,Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England,Penn State Univ, Dept Surg, Div Urol, Hershey, PA USA
Ward, Douglas G. (författare)
Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham
Goel, Anshita (författare)
Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham
Hurst, Carolyn D. (författare)
Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England
Raman, Jay D. (författare)
Penn State Univ, Dept Surg, Div Urol, Hershey, PA USA
Warrick, Joshua I. (författare)
Penn State Univ, Dept Biochem & Mol Biol, Dept Pathol & Lab Med, Div Urol, Hershey, PA USA,Pennsylvania State University
Segersten, Ulrika (författare)
Uppsala University,Uppsala universitet,Urologkirurgi
Sikic, Danijel (författare)
Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Urol & Pediat Urol, Erlangen, Germany,University Hospital Erlangen
van Kessel, Kim E. M. (författare)
Erasmus MC, Erasmus MC Canc Inst, Dept Pathol, Rotterdam, Netherlands,Erasmus University Medical Center
Maurer, Tobias (författare)
Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany; Univ Med Ctr Hamburg Eppendorf, Dept Urol, Hamburg, Germany.;Univ Med Ctr Hamburg Eppendorf, Martini Clin, Hamburg, Germany,University Medical Center Hamburg-Eppendorf
Meeks, Joshua J. (författare)
Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine
DeGraff, David J. (författare)
Penn State Univ, Dept Biochem & Mol Biol, Dept Pathol & Lab Med, Div Urol, Hershey, PA USA,Pennsylvania State University
Bryan, Richard T. (författare)
Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham
Knowles, Margaret A. (författare)
Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England,Leeds School of Medicine
Simic, Tatjana (författare)
Univ Belgrade, Fac Med, Inst Med & Clin Biochem, Belgrade, Serbia,University of Belgrade
Hartmann, Arndt (författare)
Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Inst Pathol, Erlangen, Germany,University Hospital Erlangen
Zwarthoff, Ellen C. (författare)
Erasmus MC, Erasmus MC Canc Inst, Dept Pathol, Rotterdam, Netherlands,Erasmus University Medical Center
Malmström, Per-Uno (författare)
Uppsala University,Uppsala universitet,Urologkirurgi
Malats, Núria (författare)
CIBERONC, Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain,Spanish National Cancer Research Center (CNIO)
Real, Francisco X. (författare)
Spanish Natl Canc Res Ctr CNIO, Epithelial Carcinogenesis Grp, Madrid, Spain; Univ Pompeu Fabra, Dept Ciencies Expt & Salut, CIBERONC, Barcelona, Spain,Pompeu Fabra University,Spanish National Cancer Research Center (CNIO)
Dyrskjøt, Lars (författare)
Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital
visa färre...
 (creator_code:org_t)
2021-04-16
2021
Engelska.
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients diagnosed with NMIBC (n=834). Transcriptomic analysis identifies four classes (1, 2a, 2b and 3) reflecting tumor biology and disease aggressiveness. Both transcriptome-based subtyping and the level of chromosomal instability provide independent prognostic value beyond established prognostic clinicopathological parameters. High chromosomal instability, p53-pathway disruption and APOBEC-related mutations are significantly associated with transcriptomic class 2a and poor outcome. RNA-derived immune cell infiltration is associated with chromosomally unstable tumors and enriched in class 2b. Spatial proteomics analysis confirms the higher infiltration of class 2b tumors and demonstrates an association between higher immune cell infiltration and lower recurrence rates. Finally, the independent prognostic value of the transcriptomic classes is documented in 1228 validation samples using a single sample classification tool. The classifier provides a framework for biomarker discovery and for optimizing treatment and surveillance in next-generation clinical trials.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

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