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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Heid, Iris M (author)
Jackson, Anne U (author)
Randall, Joshua C (author)
show more...
Winkler, Thomas W (author)
Qi, Lu (author)
Steinthorsdottir, Valgerdur (author)
Thorleifsson, Gudmar (author)
Zillikens, M Carola (author)
Speliotes, Elizabeth K (author)
Mägi, Reedik (author)
Workalemahu, Tsegaselassie (author)
White, Charles C (author)
Bouatia-Naji, Nabila (author)
Harris, Tamara B (author)
Berndt, Sonja I (author)
Ingelsson, Erik (author)
Karolinska Institutet
Willer, Cristen J (author)
Weedon, Michael N (author)
Luan, Jian'an (author)
Vedantam, Sailaja (author)
Esko, Tõnu (author)
Kilpeläinen, Tuomas O (author)
Kutalik, Zoltán (author)
Li, Shengxu (author)
Monda, Keri L (author)
Dixon, Anna L (author)
Holmes, Christopher C (author)
Kaplan, Lee M (author)
Liang, Liming (author)
Min, Josine L (author)
Moffatt, Miriam F (author)
Molony, Cliona (author)
Nicholson, George (author)
Schadt, Eric E (author)
Zondervan, Krina T (author)
Feitosa, Mary F (author)
Ferreira, Teresa (author)
Allen, Hana Lango (author)
Weyant, Robert J (author)
Wheeler, Eleanor (author)
Wood, Andrew R (author)
Estrada, Karol (author)
Goddard, Michael E (author)
Lettre, Guillaume (author)
Mangino, Massimo (author)
Nyholt, Dale R (author)
Purcell, Shaun (author)
Smith, Albert Vernon (author)
Visscher, Peter M (author)
Yang, Jian (author)
McCarroll, Steven A (author)
Nemesh, James (author)
Voight, Benjamin F (author)
Absher, Devin (author)
Amin, Najaf (author)
Aspelund, Thor (author)
Coin, Lachlan (author)
Glazer, Nicole L (author)
Hayward, Caroline (author)
Heard-Costa, Nancy L (author)
Hottenga, Jouke-Jan (author)
Johansson, Åsa (author)
Uppsala universitet,Genomik,Gyllensten
Johnson, Toby (author)
Kaakinen, Marika (author)
Kapur, Karen (author)
Ketkar, Shamika (author)
Knowles, Joshua W (author)
Kraft, Peter (author)
Kraja, Aldi T (author)
Lamina, Claudia (author)
Leitzmann, Michael F (author)
McKnight, Barbara (author)
Morris, Andrew P (author)
Ong, Ken K (author)
Perry, John R B (author)
Peters, Marjolein J (author)
Polasek, Ozren (author)
Prokopenko, Inga (author)
Rayner, Nigel W (author)
Ripatti, Samuli (author)
Rivadeneira, Fernando (author)
Robertson, Neil R (author)
Sanna, Serena (author)
Sovio, Ulla (author)
Surakka, Ida (author)
Teumer, Alexander (author)
van Wingerden, Sophie (author)
Vitart, Veronique (author)
Zhao, Jing Hua (author)
Cavalcanti-Proença, Christine (author)
Chines, Peter S (author)
Fisher, Eva (author)
Kulzer, Jennifer R (author)
Lecoeur, Cecile (author)
Narisu, Narisu (author)
Sandholt, Camilla (author)
Scott, Laura J (author)
Silander, Kaisa (author)
Stark, Klaus (author)
Tammesoo, Mari-Liis (author)
Teslovich, Tanya M (author)
Timpson, Nicholas John (author)
Watanabe, Richard M (author)
Welch, Ryan (author)
Chasman, Daniel I (author)
Cooper, Matthew N (author)
Jansson, John-Olov, 1954 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
Kettunen, Johannes (author)
Lawrence, Robert W (author)
Pellikka, Niina (author)
Perola, Markus (author)
Vandenput, Liesbeth, 1974 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
Alavere, Helene (author)
Almgren, Peter (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Atwood, Larry D (author)
Bennett, Amanda J (author)
Biffar, Reiner (author)
Bonnycastle, Lori L (author)
Bornstein, Stefan R (author)
Buchanan, Thomas A (author)
Campbell, Harry (author)
Day, Ian N M (author)
Dei, Mariano (author)
Dörr, Marcus (author)
Elliott, Paul (author)
Erdos, Michael R (author)
Eriksson, Johan G (author)
Freimer, Nelson B (author)
Fu, Mao (author)
Gaget, Stefan (author)
Geus, Eco J C (author)
Gjesing, Anette P (author)
Grallert, Harald (author)
Grässler, Jürgen (author)
Groves, Christopher J (author)
Guiducci, Candace (author)
Hartikainen, Anna-Liisa (author)
Hassanali, Neelam (author)
Havulinna, Aki S (author)
Herzig, Karl-Heinz (author)
Hicks, Andrew A (author)
Hui, Jennie (author)
Igl, Wilmar (author)
Uppsala universitet,Institutionen för genetik och patologi
Jousilahti, Pekka (author)
Jula, Antti (author)
Kajantie, Eero (author)
Kinnunen, Leena (author)
Kolcic, Ivana (author)
Koskinen, Seppo (author)
Kovacs, Peter (author)
Kroemer, Heyo K (author)
Krzelj, Vjekoslav (author)
Kuusisto, Johanna (author)
Kvaloy, Kirsti (author)
Laitinen, Jaana (author)
Lantieri, Olivier (author)
Lathrop, G Mark (author)
Lokki, Marja-Liisa (author)
Luben, Robert N (author)
Ludwig, Barbara (author)
McArdle, Wendy L (author)
McCarthy, Anne (author)
Morken, Mario A (author)
Nelis, Mari (author)
Neville, Matt J (author)
Paré, Guillaume (author)
Parker, Alex N (author)
Peden, John F (author)
Pichler, Irene (author)
Pietiläinen, Kirsi H (author)
Platou, Carl G P (author)
Pouta, Anneli (author)
Ridderstråle, Martin (author)
Lund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups
Samani, Nilesh J (author)
Saramies, Jouko (author)
Sinisalo, Juha (author)
Smit, Jan H (author)
Strawbridge, Rona J (author)
Karolinska Institutet
Stringham, Heather M (author)
Swift, Amy J (author)
Teder-Laving, Maris (author)
Thomson, Brian (author)
Usala, Gianluca (author)
van Meurs, Joyce B J (author)
van Ommen, Gert-Jan (author)
Vatin, Vincent (author)
Volpato, Claudia B (author)
Wallaschofski, Henri (author)
Walters, G Bragi (author)
Widen, Elisabeth (author)
Wild, Sarah H (author)
Willemsen, Gonneke (author)
Witte, Daniel R (author)
Zgaga, Lina (author)
Zitting, Paavo (author)
Beilby, John P (author)
James, Alan L (author)
Kähönen, Mika (author)
Lehtimäki, Terho (author)
Nieminen, Markku S (author)
Ohlsson, Claes, 1965 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine
Palmer, Lyle J (author)
Raitakari, Olli (author)
Ridker, Paul M (author)
Stumvoll, Michael (author)
Tönjes, Anke (author)
Viikari, Jorma (author)
Balkau, Beverley (author)
Ben-Shlomo, Yoav (author)
Bergman, Richard N (author)
Boeing, Heiner (author)
Smith, George Davey (author)
Ebrahim, Shah (author)
Froguel, Philippe (author)
Hansen, Torben (author)
Hengstenberg, Christian (author)
Hveem, Kristian (author)
Isomaa, Bo (author)
Jørgensen, Torben (author)
Karpe, Fredrik (author)
Khaw, Kay-Tee (author)
Laakso, Markku (author)
Lawlor, Debbie A (author)
Marre, Michel (author)
Meitinger, Thomas (author)
Metspalu, Andres (author)
Midthjell, Kristian (author)
Pedersen, Oluf (author)
Salomaa, Veikko (author)
Schwarz, Peter E H (author)
Tuomi, Tiinamaija (author)
Tuomilehto, Jaakko (author)
Valle, Timo T (author)
Wareham, Nicholas J (author)
Arnold, Alice M (author)
Beckmann, Jacques S (author)
Bergmann, Sven (author)
Boerwinkle, Eric (author)
Boomsma, Dorret I (author)
Caulfield, Mark J (author)
Collins, Francis S (author)
Eiriksdottir, Gudny (author)
Gudnason, Vilmundur (author)
Gyllensten, Ulf (author)
Uppsala universitet,Institutionen för genetik och patologi,Gyllensten
Hamsten, Anders (author)
Karolinska Institutet
Hattersley, Andrew T (author)
Hofman, Albert (author)
Hu, Frank B (author)
Illig, Thomas (author)
Iribarren, Carlos (author)
Jarvelin, Marjo-Riitta (author)
Kao, W H Linda (author)
Kaprio, Jaakko (author)
Launer, Lenore J (author)
Munroe, Patricia B (author)
Oostra, Ben (author)
Penninx, Brenda W (author)
Pramstaller, Peter P (author)
Psaty, Bruce M (author)
Quertermous, Thomas (author)
Rissanen, Aila (author)
Rudan, Igor (author)
Shuldiner, Alan R (author)
Soranzo, Nicole (author)
Spector, Timothy D (author)
Syvänen, Ann-Christine (author)
Uppsala universitet,Molekylär medicin
Uda, Manuela (author)
Uitterlinden, André (author)
Völzke, Henry (author)
Vollenweider, Peter (author)
Wilson, James F (author)
Witteman, Jacqueline C (author)
Wright, Alan F (author)
Abecasis, Gonçalo R (author)
Boehnke, Michael (author)
Borecki, Ingrid B (author)
Deloukas, Panos (author)
Frayling, Timothy M (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Haritunians, Talin (author)
Hunter, David J (author)
Kaplan, Robert C (author)
North, Kari E (author)
O'Connell, Jeffrey R (author)
Peltonen, Leena (author)
Schlessinger, David (author)
Strachan, David P (author)
Hirschhorn, Joel N (author)
Assimes, Themistocles L (author)
Wichmann, H-Erich (author)
Thorsteinsdottir, Unnur (author)
van Duijn, Cornelia M (author)
Stefansson, Kari (author)
Cupples, L Adrienne (author)
Loos, Ruth J F (author)
Barroso, Inês (author)
McCarthy, Mark I (author)
Fox, Caroline S (author)
Mohlke, Karen L (author)
Lindgren, Cecilia M (author)
Luan, Jianan (author)
show less...
 (creator_code:org_t)
2010-10-10
2010
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

MEDICINE
MEDICIN

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art (subject category)

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By the author/editor
Heid, Iris M
Jackson, Anne U
Randall, Joshua ...
Winkler, Thomas ...
Qi, Lu
Steinthorsdottir ...
show more...
Thorleifsson, Gu ...
Zillikens, M Car ...
Speliotes, Eliza ...
Mägi, Reedik
Workalemahu, Tse ...
White, Charles C
Bouatia-Naji, Na ...
Harris, Tamara B
Berndt, Sonja I
Ingelsson, Erik
Willer, Cristen ...
Weedon, Michael ...
Luan, Jian'an
Vedantam, Sailaj ...
Esko, Tõnu
Kilpeläinen, Tuo ...
Kutalik, Zoltán
Li, Shengxu
Monda, Keri L
Dixon, Anna L
Holmes, Christop ...
Kaplan, Lee M
Liang, Liming
Min, Josine L
Moffatt, Miriam ...
Molony, Cliona
Nicholson, Georg ...
Schadt, Eric E
Zondervan, Krina ...
Feitosa, Mary F
Ferreira, Teresa
Allen, Hana Lang ...
Weyant, Robert J
Wheeler, Eleanor
Wood, Andrew R
Estrada, Karol
Goddard, Michael ...
Lettre, Guillaum ...
Mangino, Massimo
Nyholt, Dale R
Purcell, Shaun
Smith, Albert Ve ...
Visscher, Peter ...
Yang, Jian
McCarroll, Steve ...
Nemesh, James
Voight, Benjamin ...
Absher, Devin
Amin, Najaf
Aspelund, Thor
Coin, Lachlan
Glazer, Nicole L
Hayward, Carolin ...
Heard-Costa, Nan ...
Hottenga, Jouke- ...
Johansson, Åsa
Johnson, Toby
Kaakinen, Marika
Kapur, Karen
Ketkar, Shamika
Knowles, Joshua ...
Kraft, Peter
Kraja, Aldi T
Lamina, Claudia
Leitzmann, Micha ...
McKnight, Barbar ...
Morris, Andrew P
Ong, Ken K
Perry, John R B
Peters, Marjolei ...
Polasek, Ozren
Prokopenko, Inga
Rayner, Nigel W
Ripatti, Samuli
Rivadeneira, Fer ...
Robertson, Neil ...
Sanna, Serena
Sovio, Ulla
Surakka, Ida
Teumer, Alexande ...
van Wingerden, S ...
Vitart, Veroniqu ...
Zhao, Jing Hua
Cavalcanti-Proen ...
Chines, Peter S
Fisher, Eva
Kulzer, Jennifer ...
Lecoeur, Cecile
Narisu, Narisu
Sandholt, Camill ...
Scott, Laura J
Silander, Kaisa
Stark, Klaus
Tammesoo, Mari-L ...
Teslovich, Tanya ...
Timpson, Nichola ...
Watanabe, Richar ...
Welch, Ryan
Chasman, Daniel ...
Cooper, Matthew ...
Jansson, John-Ol ...
Kettunen, Johann ...
Lawrence, Robert ...
Pellikka, Niina
Perola, Markus
Vandenput, Liesb ...
Alavere, Helene
Almgren, Peter
Atwood, Larry D
Bennett, Amanda ...
Biffar, Reiner
Bonnycastle, Lor ...
Bornstein, Stefa ...
Buchanan, Thomas ...
Campbell, Harry
Day, Ian N M
Dei, Mariano
Dörr, Marcus
Elliott, Paul
Erdos, Michael R
Eriksson, Johan ...
Freimer, Nelson ...
Fu, Mao
Gaget, Stefan
Geus, Eco J C
Gjesing, Anette ...
Grallert, Harald
Grässler, Jürgen
Groves, Christop ...
Guiducci, Candac ...
Hartikainen, Ann ...
Hassanali, Neela ...
Havulinna, Aki S
Herzig, Karl-Hei ...
Hicks, Andrew A
Hui, Jennie
Igl, Wilmar
Jousilahti, Pekk ...
Jula, Antti
Kajantie, Eero
Kinnunen, Leena
Kolcic, Ivana
Koskinen, Seppo
Kovacs, Peter
Kroemer, Heyo K
Krzelj, Vjekosla ...
Kuusisto, Johann ...
Kvaloy, Kirsti
Laitinen, Jaana
Lantieri, Olivie ...
Lathrop, G Mark
Lokki, Marja-Lii ...
Luben, Robert N
Ludwig, Barbara
McArdle, Wendy L
McCarthy, Anne
Morken, Mario A
Nelis, Mari
Neville, Matt J
Paré, Guillaume
Parker, Alex N
Peden, John F
Pichler, Irene
Pietiläinen, Kir ...
Platou, Carl G P
Pouta, Anneli
Ridderstråle, Ma ...
Samani, Nilesh J
Saramies, Jouko
Sinisalo, Juha
Smit, Jan H
Strawbridge, Ron ...
Stringham, Heath ...
Swift, Amy J
Teder-Laving, Ma ...
Thomson, Brian
Usala, Gianluca
van Meurs, Joyce ...
van Ommen, Gert- ...
Vatin, Vincent
Volpato, Claudia ...
Wallaschofski, H ...
Walters, G Bragi
Widen, Elisabeth
Wild, Sarah H
Willemsen, Gonne ...
Witte, Daniel R
Zgaga, Lina
Zitting, Paavo
Beilby, John P
James, Alan L
Kähönen, Mika
Lehtimäki, Terho
Nieminen, Markku ...
Ohlsson, Claes, ...
Palmer, Lyle J
Raitakari, Olli
Ridker, Paul M
Stumvoll, Michae ...
Tönjes, Anke
Viikari, Jorma
Balkau, Beverley
Ben-Shlomo, Yoav
Bergman, Richard ...
Boeing, Heiner
Smith, George Da ...
Ebrahim, Shah
Froguel, Philipp ...
Hansen, Torben
Hengstenberg, Ch ...
Hveem, Kristian
Isomaa, Bo
Jørgensen, Torbe ...
Karpe, Fredrik
Khaw, Kay-Tee
Laakso, Markku
Lawlor, Debbie A
Marre, Michel
Meitinger, Thoma ...
Metspalu, Andres
Midthjell, Krist ...
Pedersen, Oluf
Salomaa, Veikko
Schwarz, Peter E ...
Tuomi, Tiinamaij ...
Tuomilehto, Jaak ...
Valle, Timo T
Wareham, Nichola ...
Arnold, Alice M
Beckmann, Jacque ...
Bergmann, Sven
Boerwinkle, Eric
Boomsma, Dorret ...
Caulfield, Mark ...
Collins, Francis ...
Eiriksdottir, Gu ...
Gudnason, Vilmun ...
Gyllensten, Ulf
Hamsten, Anders
Hattersley, Andr ...
Hofman, Albert
Hu, Frank B
Illig, Thomas
Iribarren, Carlo ...
Jarvelin, Marjo- ...
Kao, W H Linda
Kaprio, Jaakko
Launer, Lenore J
Munroe, Patricia ...
Oostra, Ben
Penninx, Brenda ...
Pramstaller, Pet ...
Psaty, Bruce M
Quertermous, Tho ...
Rissanen, Aila
Rudan, Igor
Shuldiner, Alan ...
Soranzo, Nicole
Spector, Timothy ...
Syvänen, Ann-Chr ...
Uda, Manuela
Uitterlinden, An ...
Völzke, Henry
Vollenweider, Pe ...
Wilson, James F
Witteman, Jacque ...
Wright, Alan F
Abecasis, Gonçal ...
Boehnke, Michael
Borecki, Ingrid ...
Deloukas, Panos
Frayling, Timoth ...
Groop, Leif
Haritunians, Tal ...
Hunter, David J
Kaplan, Robert C
North, Kari E
O'Connell, Jeffr ...
Peltonen, Leena
Schlessinger, Da ...
Strachan, David ...
Hirschhorn, Joel ...
Assimes, Themist ...
Wichmann, H-Eric ...
Thorsteinsdottir ...
van Duijn, Corne ...
Stefansson, Kari
Cupples, L Adrie ...
Loos, Ruth J F
Barroso, Inês
McCarthy, Mark I
Fox, Caroline S
Mohlke, Karen L
Lindgren, Cecili ...
Luan, Jianan
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Physiology
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Nutrition and Di ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
Articles in the publication
Nature Genetics
By the university
Uppsala University
University of Gothenburg
Lund University
Karolinska Institutet

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