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Impact of pathogen reduction methods on immunological properties of the COVID-19 convalescent plasma
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- Kostin, Alexander I. (author)
- N.V. Sklifosovsky Research Institute of Emergency Medicine
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- Lundgren, Maria N. (author)
- Region Skåne
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- Bulanov, Andrey Y. (author)
- N.V. Sklifosovsky Research Institute of Emergency Medicine
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- Ladygina, Elena A. (author)
- N.V. Sklifosovsky Research Institute of Emergency Medicine
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- Chirkova, Karina S. (author)
- N.V. Sklifosovsky Research Institute of Emergency Medicine
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- Gintsburg, Alexander L. (author)
- Gamaleya Research Institute of Epidemiology and Microbiology
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- Logunov, Denis Y. (author)
- Gamaleya Research Institute of Epidemiology and Microbiology
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- Dolzhikova, Inna V. (author)
- Gamaleya Research Institute of Epidemiology and Microbiology
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- Shcheblyakov, Dmitry V. (author)
- Gamaleya Research Institute of Epidemiology and Microbiology
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- Borovkova, Natalia V. (author)
- N.V. Sklifosovsky Research Institute of Emergency Medicine
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- Godkov, Mikhail A. (author)
- N.V. Sklifosovsky Research Institute of Emergency Medicine
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- Bazhenov, Alexey I. (author)
- N.V. Sklifosovsky Research Institute of Emergency Medicine
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- Shustov, Valeriy V. (author)
- N.V. Sklifosovsky Research Institute of Emergency Medicine
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- Bogdanova, Alina S. (author)
- N.V. Sklifosovsky Research Institute of Emergency Medicine
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- Kamalova, Alina R. (author)
- Pirogov Russian National Research Medical University (RNRMU)
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- Ganchin, Vladimir V. (author)
- Centre of Social Sector Analytical Development, Moscow
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- Dombrovskiy, Eugene A. (author)
- Centre of Social Sector Analytical Development, Moscow
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- Volkov, Stanislav E. (author)
- Lund University,Lunds universitet,Probability and Inference Theory Group,Forskargrupper vid Lunds universitet,Matematisk statistik,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Lund University Research Groups,Mathematical Statistics,Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH
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- Drozdova, Nataliya E. (author)
- N.V. Sklifosovsky Research Institute of Emergency Medicine
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- Petrikov, Sergey S. (author)
- N.V. Sklifosovsky Research Institute of Emergency Medicine
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NV. Sklifosovsky Research Institute of Emergency Medicine Region Skåne (creator_code:org_t)
- 2021-03-18
- 2021
- English.
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In: Vox Sanguinis. - : Wiley. - 0042-9007 .- 1423-0410. ; 116:6, s. 665-672
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http://dx.doi.org/10...
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https://www.ncbi.nlm...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background and objectives: COVID-19 convalescent plasma is an experimental treatment against SARS-CoV-2. The aim of this study is to assess the impact of different pathogen reduction methods on the levels and virus neutralizing activity of the specific antibodies against SARS-CoV2 in convalescent plasma. Materials and methods: A total of 140 plasma doses collected by plasmapheresis from COVID-19 convalescent donors were subjected to pathogen reduction by three methods: methylene blue (M)/visible light, riboflavin (R)/UVB and amotosalen (A)/UVA. To conduct a paired comparison, individual plasma doses were divided into 2 samples that were subjected to one of these methods. The titres of SARS-CoV2 neutralizing antibodies (NtAbs) and levels of specific immunoglobulins to RBD, S- and N-proteins of SARS-CoV-2 were measured before and after pathogen reduction. Results: The methods reduced NtAbs titres differently: among units with the initial titre 80 or above, 81% of units remained unchanged and 19% decreased by one step after methylene blue; 60% were unchanged and 40% decreased by one step after amotosalen; after riboflavin 43% were unchanged and 50% (7%, respectively) had a one-step (two-step, respectively) decrease. Paired two-sample comparisons (M vs. A, M vs. R and A vs. R) revealed that the largest statistically significant decrease in quantity and activity of the specific antibodies resulted from the riboflavin treatment. Conclusion: Pathogen reduction with methylene blue or with amotosalen provides the greater likelihood of preserving the immunological properties of the COVID-19 convalescent plasma compared to riboflavin.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- amotosalen
- COVID-19 convalescent plasma
- methylene blue
- NtAbs
- pathogen reduction
- riboflavin
Publication and Content Type
- art (subject category)
- ref (subject category)
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Kostin, Alexande ...
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Lundgren, Maria ...
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Bulanov, Andrey ...
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Ladygina, Elena ...
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Chirkova, Karina ...
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Gintsburg, Alexa ...
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Logunov, Denis Y ...
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Dolzhikova, Inna ...
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Shcheblyakov, Dm ...
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Borovkova, Natal ...
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Godkov, Mikhail ...
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Bazhenov, Alexey ...
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Shustov, Valeriy ...
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Bogdanova, Alina ...
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Kamalova, Alina ...
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Ganchin, Vladimi ...
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Dombrovskiy, Eug ...
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Volkov, Stanisla ...
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Drozdova, Natali ...
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Petrikov, Sergey ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Vox Sanguinis
- By the university
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Lund University