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The Relationships b...
The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men.
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O'Connor, Daryl B (författare)
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Lee, David M (författare)
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Corona, Giovanni (författare)
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Forti, Gianni (författare)
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Tajar, Abdelouahid (författare)
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O'Neill, Terence W (författare)
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Pendleton, Neil (författare)
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Bartfai, Gyorgy (författare)
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Boonen, Steven (författare)
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Casanueva, Felipe F (författare)
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Finn, Joseph D (författare)
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- Giwercman, Aleksander (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine
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Han, Thang S (författare)
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Huhtaniemi, Ilpo T (författare)
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Kula, Krzysztof (författare)
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Labrie, Fernand (författare)
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Lean, Michael E J (författare)
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Punab, Margus (författare)
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Silman, Alan J (författare)
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Vanderschueren, Dirk (författare)
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Wu, Frederick C W (författare)
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(creator_code:org_t)
- The Endocrine Society, 2011
- 2011
- Engelska.
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 96, s. 1577-1587
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Context: Limited data are available exploring the associations between sex hormones, multiple domains of sexual functioning, and sexual function-related distress in nonpatient samples in Europe. Objectives: The aim of the study was to investigate the relationships between serum testosterone (T), estradiol (E2), and dihydrotestosterone (DHT) and sexual function in a multicenter population-based study of aging in men. Design: Using stratified random sampling, 2838 men aged 40-79 yr completed the European Male Ageing Study-Sexual Function Questionnaire and provided a blood sample for hormone measurements. T, E2, and DHT were measured using gas chromatography-mass spectrometry. Setting: We conducted a community-based population survey in eight European centers. Main Outcome Measures: Self-reported sexual function (overall sexual function, sexual function-related distress, erectile dysfunction, masturbation) was measured. Results: Total and free T, but not E2 or DHT, was associated with overall sexual function in middle-aged and older men. E2 was the only hormone associated with sexual function-related distress such that higher levels were related to greater distress. Free T levels were associated with masturbation frequency and erectile dysfunction in the fully adjusted models, such that higher T was associated with less dysfunction and greater frequency. Moreover, there was a T threshold for the relationship between total T, sexual function, and erectile dysfunction. At T concentrations of 8 nmol/liter or less, T was associated with worse sexual functioning, whereas at T levels over 8 nmol/liter, the relationship came to a plateau. Conclusions: These findings suggest that different hormonal mechanisms may regulate sexual functioning (T) vs. the psychological aspects (E2) of male sexual behavior. Moreover, there was a T threshold for overall sexual function such that at levels greater than 8 nmol/liter the relationship between T and sexual function did not become stronger.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Av författaren/redakt...
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O'Connor, Daryl ...
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Lee, David M
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Corona, Giovanni
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Forti, Gianni
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Tajar, Abdelouah ...
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O'Neill, Terence ...
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visa fler...
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Pendleton, Neil
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Bartfai, Gyorgy
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Boonen, Steven
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Casanueva, Felip ...
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Finn, Joseph D
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Giwercman, Aleks ...
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Han, Thang S
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Huhtaniemi, Ilpo ...
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Kula, Krzysztof
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Labrie, Fernand
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Lean, Michael E ...
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Punab, Margus
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Silman, Alan J
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Vanderschueren, ...
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Wu, Frederick C ...
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visa färre...
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Lunds universitet