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Sökning: onr:"swepub:oai:DiVA.org:umu-181786" > Genome-wide associa...

Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

Lesseur, Corina (författare)
Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, NY, New York, United States
Ferreiro-Iglesias, Aida (författare)
Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
McKay, James D. (författare)
Section of Genetics, Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
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Bossé, Yohan (författare)
Department of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec City, Canada
Johansson, Mattias (författare)
Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
Gaborieau, Valerie (författare)
Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
Landi, Maria Teresa (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Christiani, David C. (författare)
Department of Environmental Health, Harvard TH Chan School of Public Health, Massachusetts General Hospital, MA, Boston, United States,University of Washington
Caporaso, Neil C. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Bojesen, Stig E. (författare)
Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen, Denmark
Amos, Christopher I. (författare)
Department of Medicine, Baylor college of Medicine, TX, Houston, United States
Shete, Sanjay (författare)
Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, TX, Houston, United States
Liu, Geoffrey (författare)
Lunenfeld-Tanenbaum Research Institute of Sinai Health System, University of Toronto, Toronto, Canada
Rennert, Gadi (författare)
Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
Albanes, Demetrios (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Aldrich, Melinda C. (författare)
Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, TN, Nashville, United States
Tardon, Adonina (författare)
Faculty of Medicine, University of Oviedo, CIBERESP, Oviedo, Spain
Chen, Chu (författare)
Department of Epidemiology, University of Washington School of Public Health and Community Medicine, WA, Seattle, United States
Triantafillos, Liloglou (författare)
Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom,Liverpool Hope University
Field, John K. (författare)
Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom,Liverpool Hope University
Teare, Marion Dawn (författare)
School of Health and Related Research, University Of Sheffield, Sheffield, United Kingdom,Sheffield Hallam University
Kiemeney, Lambertus A. (författare)
Radboud University Medical Center, Nijmegen, Netherlands
Diergaarde, Brenda (författare)
Department of Human Genetics, University of Pittsburgh, PA, Pittsburgh, United States; Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States
Ferris, Robert L. (författare)
UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States
Zienolddiny, Shanbeh (författare)
National Institute of Occupational Health, Oslo, Norway
Lam, Stephen (författare)
British Columbia Cancer Agency, Vancouver, Canada
Olshan, Andrew F. (författare)
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States
Weissler, Mark C. (författare)
Department of Otolaryngology/Head and Neck Surgery, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States
Lacko, Martin (författare)
Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, Netherlands
Risch, Angela (författare)
University of Salzburg, Department of Biosciences and Cancer Cluster Salzburg, Salzburg, Austria; Division of Epigenomics, DKFZ – German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany
Bickeböller, Heike (författare)
Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany
Ness, Andy R. (författare)
National Institute for Health Research (NIHR), Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom; Bristol Dental School, University of Bristol, Bristol, United Kingdom
Thomas, Steve (författare)
Bristol Dental School, University of Bristol, Bristol, United Kingdom
Le Marchand, Loic (författare)
Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii, HI, Honolulu, United States
Schabath, Matthew B. (författare)
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States
Wünsch-Filho, Victor (författare)
Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil
Tajara, Eloiza H. (författare)
Department of Molecular Biology, School of Medicine of São José do Rio Preto, São José do Rio Preto, Brazil
Andrew, Angeline S. (författare)
Biomedical Data Science, Geisel School of Medicine at Dartmouth, Dartmouth College, NH, Hanover, United States
Clifford, Gary M. (författare)
Infections Section, Infections and Cancer Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
Lazarus, Philip (författare)
Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States
Grankvist, Kjell (författare)
Umeå University,Umeå universitet,Klinisk kemi
Johansson, Mikael (författare)
Umeå University,Umeå universitet,Onkologi
Arnold, Susanne (författare)
Markey Cancer Center, University of Kentucky, KY, Lexington, United States
Melander, Olle (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Brunnström, Hans (författare)
Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
Boccia, Stefania (författare)
Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italy; Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy,Catholic University of the Sacred Heart, Rome
Cadoni, Gabriella (författare)
Dipartimento Patologia Testa Collo e Organi di Senso, Istituto di Clinica Otorinolaringoiatrica, Università Cattolica del Sacro Cuore, Roma, Italy; Dipartimento di Scienze dell’Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
Timens, Wim (författare)
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; GRIAC Research Institute, University of Groningen, Groningen, Netherlands
Obeidat, Ma'en (författare)
Centre for Heart Lung Innovation, St Paul’s Hospital, The University of British Columbia, Vancouver, Canada
Xiao, Xiangjun (författare)
Department of Medicine, Baylor college of Medicine, TX, Houston, United States
Houlston, Richard S. (författare)
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom
Hung, Rayjean J. (författare)
Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada
Brennan, Paul (författare)
Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
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 (creator_code:org_t)
et al 
2021-03-05
2021
Engelska.
Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 17:3
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta<5x10-8) aerodigestive SqCC susceptibility loci in the 2q33.1 region (rs56321285, TMEM273). Additionally, three previously unknown loci reached suggestive significance (Pmeta<5x10-7): 1q32.1 (rs12133735, near MDM4), 5q31.2 (rs13181561, TMEM173) and 19p13.11 (rs61494113, ABHD8). Multiple previously identified loci for aerodigestive SqCC also showed evidence of pleiotropy in at least another SqCC site, these include: 4q23 (ADH1B), 6p21.33 (STK19), 6p21.32 (HLA-DQB1), 9p21.33 (CDKN2B-AS1) and 13q13.1(BRCA2). Gene-based association and gene set enrichment identified a set of 48 SqCC-related genes to DNA damage and epigenetic regulation pathways. Our study highlights the importance of cross-cancer analyses to identify pleiotropic risk loci of histology-related cancers arising at distinct anatomical sites.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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