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Dynamic changes in ...
Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes
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- Brænne, Ingrid (författare)
- University of Virginia
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- Onengut-Gumuscu, Suna (författare)
- University of Virginia
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- Chen, Ruoxi (författare)
- University of Virginia
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visa fler...
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- Manichaikul, Ani (författare)
- University of Virginia
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- Rich, Stephen (författare)
- University of Virginia
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- Chen, Wei-Min (författare)
- University of Virginia
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- Farber, Charles (författare)
- University of Virginia
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- Lernmark, Åke (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Agardh, Daniel (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Aronsson, Carin Andrén (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ask, Maria (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Bennet, Rasmus (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Cilio, Corrado (creator_code:cre_t)
- Lund University,Lunds universitet,Diabetes - immunovirologi,Forskargrupper vid Lunds universitet,Diabetes - Immunovirology,Lund University Research Groups
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- Engqvist, Helene (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ericson-Hallström, Emelie (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Fransson, Lina (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Gard, Thomas (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Hansen, Monika (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Jisser, Hanna (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Johansen, Fredrik (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Jonsdottir, Berglind (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Jovic, Silvija (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Larsson, Helena Elding (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Neonatologi,Paediatric Endocrinology,Lund University Research Groups,Neonatology
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- Lindström, Marielle (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Lundgren, Markus (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Maziarz, Marlena (creator_code:cre_t)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
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- Månsson-Martinez, Maria (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Markan, Maria (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Mestan, Zeliha (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ottosson, Karin (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Rahmati, Kobra (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ramelius, Anita (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Salami, Falastin (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Sjöberg, Anette (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Sjöberg, Birgitta (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Svensson, Malin (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Törn, Carina (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Wallin, Anne (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Wimar, Åsa (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Åberg, Sofie (creator_code:cre_t)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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(creator_code:org_t)
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- 2021-11-22
- 2021
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11, s. 1-13
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Significant progress has been made in elucidating genetic risk factors influencing Type 1 diabetes (T1D); however, features other than genetic variants that initiate and/or accelerate islet autoimmunity that lead to the development of clinical T1D remain largely unknown. We hypothesized that genetic and environmental risk factors can both contribute to T1D through dynamic alterations of molecular interactions in physiologic networks. To test this hypothesis, we utilized longitudinal blood transcriptomic profiles in The Environmental Determinants of Diabetes in the Young (TEDDY) study to generate gene co-expression networks. In network modules that contain immune response genes associated with T1D, we observed highly dynamic differences in module connectivity in the 600 days (~ 2 years) preceding clinical diagnosis of T1D. Our results suggest that gene co-expression is highly plastic and that connectivity differences in T1D-associated immune system genes influence the timing and development of clinical disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Av författaren/redakt...
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Brænne, Ingrid
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Onengut-Gumuscu, ...
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Chen, Ruoxi
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Manichaikul, Ani
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Rich, Stephen
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Chen, Wei-Min
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visa fler...
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Farber, Charles
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Lernmark, Åke
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Agardh, Daniel
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Aronsson, Carin ...
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Ask, Maria
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Bennet, Rasmus
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Cilio, Corrado
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Engqvist, Helene
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Ericson-Hallströ ...
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Fransson, Lina
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Gard, Thomas
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Hansen, Monika
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Jisser, Hanna
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Johansen, Fredri ...
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Jonsdottir, Berg ...
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Jovic, Silvija
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Larsson, Helena ...
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Lindström, Marie ...
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Lundgren, Markus
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Maziarz, Marlena
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Månsson-Martinez ...
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Markan, Maria
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Mestan, Zeliha
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Ottosson, Karin
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Rahmati, Kobra
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Ramelius, Anita
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Salami, Falastin
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Sjöberg, Anette
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Sjöberg, Birgitt ...
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Svensson, Malin
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Törn, Carina
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Wallin, Anne
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Wimar, Åsa
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Åberg, Sofie
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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