Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.

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Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.

Kalman, Janos L (author)

Papiol, Sergi (author)

Forstner, Andreas J (author)

Heilbronner, Urs (author)

Degenhardt, Franziska (author)

Strohmaier, Jana (author)

Adli, Mazda (author)

Adorjan, Kristina (author)

Akula, Nirmala (author)

Alda, Martin (author)

Anderson-Schmidt, Heike (author)

Andlauer, Till Fm (author)

Anghelescu, Ion-George (author)

Ardau, Raffaella (author)

Arias, Bárbara (author)

Arolt, Volker (author)

Aubry, Jean-Michel (author)

Backlund, Lena (author): Karolinska Institutet

Bartholdi, Kim (author)

Bauer, Michael (author)

Baune, Bernhard T (author)

Becker, Thomas (author)

Bellivier, Frank (author)

Benabarre, Antonio (author)

Bengesser, Susanne (author)

Bhattacharjee, Abesh Kumar (author)

Biernacka, Joanna M (author)

Birner, Armin (author)

Brichant-Petitjean, Clara (author)

Budde, Monika (author)

Cervantes, Pablo (author)

Chillotti, Caterina (author): Karolinska Institutet

Cichon, Sven (author)

Clark, Scott R (author)

Colom, Francesc (author)

Comes, Ashley L (author)

Cruceanu, Cristiana (author)

Czerski, Piotr M (author)

Dannlowski, Udo (author)

Dayer, Alexandre (author)

Del Zompo, Maria (author)

DePaulo, Jay Raymond (author)

Dietrich, Detlef E (author)

Étain, Bruno (author)

Ethofer, Thomas (author)

Falkai, Peter (author)

Fallgatter, Andreas (author)

Figge, Christian (author)

Flatau, Laura (author)

Folkerts, Here (author)

Frisen, Louise (author): Karolinska Institutet

Frye, Mark A (author)

Fullerton, Janice M (author)

Gade, Katrin (author)

Gard, Sébastien (author)

Garnham, Julie S (author)

Goes, Fernando S (author)

Grigoroiu-Serbanescu, Maria (author)

Gryaznova, Anna (author)

Hake, Maria (author)

Hauser, Joanna (author)

Herms, Stefan (author)

Hoffmann, Per (author)

Hou, Liping (author)

Jäger, Markus (author)

Jamain, Stephane (author)

Jiménez, Esther (author)

Juckel, Georg (author)

Kahn, Jean-Pierre (author)

Kassem, Layla (author)

Kelsoe, John (author)

Kittel-Schneider, Sarah (author)

Kliwicki, Sebastian (author)

Klohn-Sagatholislam, Farah (author)

Koller, Manfred (author)

König, Barbara (author)

Konrad, Carsten (author)

Lackner, Nina (author)

Laje, Gonzalo (author)

Landén, Mikael, 1966 (author): Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology

Lang, Fabian U (author)

Lavebratt, Catharina (author)

Leboyer, Marion (author)

Leckband, Susan G (author)

Maj, Mario (author): Karolinska Institutet

Manchia, Mirko (author)

Martinsson, Lina (author): Karolinska Institutet

McCarthy, Michael J (author)

McElroy, Susan L (author)

McMahon, Francis J (author)

Mitchell, Philip B (author)

Mitjans, Marina (author)

Mondimore, Francis M (author)

Monteleone, Palmiero (author)

Nieratschker, Vanessa (author)

Nievergelt, Caroline M (author)

Novák, Tomas (author)

Ösby, Urban (author)

Pfennig, Andrea (author)

Potash, James B (author)

Reich-Erkelenz, Daniela (author)

Reif, Andreas (author)

Reimer, Jens (author)

Reininghaus, Eva (author)

Reitt, Markus (author)

Ripke, Stephan (author)

Rouleau, Guy A (author)

Rybakowski, Janusz K (author)

Schalling, Martin (author)

Scherk, Harald (author)

Schmauß, Max (author)

Schofield, Peter R (author)

Schubert, K Oliver (author)

Schulte, Eva C (author)

Schulz, Sybille (author)

Senner, Fanny (author)

Severino, Giovanni (author)

Shekhtman, Tatyana (author)

Shilling, Paul D (author)

Simhandl, Christian (author)

Slaney, Claire M (author)

Spitzer, Carsten (author)

Squassina, Alessio (author)

Stamm, Thomas (author)

Stegmaier, Sophia (author)

Stierl, Sebastian (author)

Stopkova, Pavla (author)

Thiel, Andreas (author)

Tighe, Sarah K (author)

Tortorella, Alfonso (author)

Turecki, Gustavo (author)

Vieta, Eduard (author)

Veeh, Julia (author)

von Hagen, Martin (author)

Wigand, Moritz E (author)

Wiltfang, Jens (author)

Witt, Stephanie (author)

Wright, Adam (author)

Zandi, Peter P (author)

Zimmermann, Jörg (author)

Nöthen, Markus (author)

Rietschel, Marcella (author)

Schulze, Thomas G (author)

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(creator_code:org_t)

2018-06-28
2019
English.
In: Bipolar disorders. - : Wiley. - 1399-5618 .- 1398-5647. ; 21:1, s. 68-75

Related links:: https://onlinelibrar...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients.A total of 1995 BD type 1 patients from the Consortium of Lithium Genetics (ConLiGen), PsyCourse and Bonn-Mannheim samples were genotyped and their BD and SCZ polygenic risk scores (PRSs) were calculated using the summary statistics of the Psychiatric Genomics Consortium as a training data set. AAO was either separated into onset groups of clinical interest (childhood and adolescence [≤18 years] vs adulthood [>18 years]) or considered as a continuous measure. The associations between BD- and SCZ-PRSs and AAO were evaluated with regression models.BD- and SCZ-PRSs were not significantly associated with age at disease onset. Results remained the same when analyses were stratified by site of recruitment.The current study is the largest conducted so far to investigate the association between the cumulative BD and SCZ polygenic risk and AAO in BD patients. The reported negative results suggest that such a polygenic influence, if there is any, is not large, and highlight the importance of conducting further, larger scale studies to obtain more information on the genetic architecture of this clinically relevant phenotype.

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By the author/editor: Kalman, Janos L; Papiol, Sergi; Forstner, Andrea ...; Heilbronner, Urs; Degenhardt, Fran ...; Strohmaier, Jana; show more...; Adli, Mazda; Adorjan, Kristin ...; Akula, Nirmala; Alda, Martin; Anderson-Schmidt ...; Andlauer, Till F ...; Anghelescu, Ion- ...; Ardau, Raffaella; Arias, Bárbara; Arolt, Volker; Aubry, Jean-Mich ...; Backlund, Lena; Bartholdi, Kim; Bauer, Michael; Baune, Bernhard ...; Becker, Thomas; Bellivier, Frank; Benabarre, Anton ...; Bengesser, Susan ...; Bhattacharjee, A ...; Biernacka, Joann ...; Birner, Armin; Brichant-Petitje ...; Budde, Monika; Cervantes, Pablo; Chillotti, Cater ...; Cichon, Sven; Clark, Scott R; Colom, Francesc; Comes, Ashley L; Cruceanu, Cristi ...; Czerski, Piotr M; Dannlowski, Udo; Dayer, Alexandre; Del Zompo, Maria; DePaulo, Jay Ray ...; Dietrich, Detlef ...; Étain, Bruno; Ethofer, Thomas; Falkai, Peter; Fallgatter, Andr ...; Figge, Christian; Flatau, Laura; Folkerts, Here; Frisen, Louise; Frye, Mark A; Fullerton, Janic ...; Gade, Katrin; Gard, Sébastien; Garnham, Julie S; Goes, Fernando S; Grigoroiu-Serban ...; Gryaznova, Anna; Hake, Maria; Hauser, Joanna; Herms, Stefan; Hoffmann, Per; Hou, Liping; Jäger, Markus; Jamain, Stephane; Jiménez, Esther; Juckel, Georg; Kahn, Jean-Pierr ...; Kassem, Layla; Kelsoe, John; Kittel-Schneider ...; Kliwicki, Sebast ...; Klohn-Sagatholis ...; Koller, Manfred; König, Barbara; Konrad, Carsten; Lackner, Nina; Laje, Gonzalo; Landén, Mikael, ...; Lang, Fabian U; Lavebratt, Catha ...; Leboyer, Marion; Leckband, Susan ...; Maj, Mario; Manchia, Mirko; Martinsson, Lina; McCarthy, Michae ...; McElroy, Susan L; McMahon, Francis ...; Mitchell, Philip ...; Mitjans, Marina; Mondimore, Franc ...; Monteleone, Palm ...; Nieratschker, Va ...; Nievergelt, Caro ...; Novák, Tomas; Ösby, Urban; Pfennig, Andrea; Potash, James B; Reich-Erkelenz, ...; Reif, Andreas; Reimer, Jens; Reininghaus, Eva; Reitt, Markus; Ripke, Stephan; Rouleau, Guy A; Rybakowski, Janu ...; Schalling, Marti ...; Scherk, Harald; Schmauß, Max; Schofield, Peter ...; Schubert, K Oliv ...; Schulte, Eva C; Schulz, Sybille; Senner, Fanny; Severino, Giovan ...; Shekhtman, Tatya ...; Shilling, Paul D; Simhandl, Christ ...; Slaney, Claire M; Spitzer, Carsten; Squassina, Aless ...; Stamm, Thomas; Stegmaier, Sophi ...; Stierl, Sebastia ...; Stopkova, Pavla; Thiel, Andreas; Tighe, Sarah K; Tortorella, Alfo ...; Turecki, Gustavo; Vieta, Eduard; Veeh, Julia; von Hagen, Marti ...; Wigand, Moritz E; Wiltfang, Jens; Witt, Stephanie; Wright, Adam; Zandi, Peter P; Zimmermann, Jörg; Nöthen, Markus; Rietschel, Marce ...; Schulze, Thomas ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: Bipolar disorder ...

By the university: University of Gothenburg; Karolinska Institutet

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Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.

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