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Sökning: onr:"swepub:oai:DiVA.org:uu-409793" > Reproductive and Ho...

Reproductive and Hormonal Factors and Risk of Ovarian Cancer by Tumor Dominance : Results from the Ovarian Cancer Cohort Consortium (OC3)

Huang, Tianyi (författare)
Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA
Townsend, Mary K. (författare)
H Lee Moffitt Canc Ctr & Res Inst, Div Populat Sci, Tampa, FL USA
Wentzensen, Nicolas (författare)
NCI, Div Canc Epidemiol & Genet, NIH, Washington, DC USA
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Trabert, Britton (författare)
NCI, Div Canc Epidemiol & Genet, NIH, Washington, DC USA
White, Emily (författare)
Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA
Arslan, Alan A. (författare)
NYU, Sch Med, Dept Populat Hlth, New York, NY USA;NYU, Dept Environm Med, Sch Med, 550 1St Ave, New York, NY 10016 USA;NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA
Weiderpass, Elisabete (författare)
WHO, Int Agcy Res Canc, Lyon, France
Buring, Julie E. (författare)
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, 181 Longwood Ave, Boston, MA 02115 USA
Clendenen, Tess V. (författare)
NYU, Sch Med, Dept Populat Hlth, New York, NY USA
Giles, Graham G. (författare)
Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia;Monash Univ, Monash Hlth, Sch Clin Sci, Precis Med, Clayton, Vic, Australia
Lee, I-Min (författare)
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, 181 Longwood Ave, Boston, MA 02115 USA
Milne, Roger L. (författare)
Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia;Monash Univ, Monash Hlth, Sch Clin Sci, Precis Med, Clayton, Vic, Australia
Onland-Moret, N. Charlotte (författare)
Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Peters, Ulrike (författare)
Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA
Sandler, Dale P. (författare)
NIEHS, Bethesda, MD USA
Schouten, Leo J. (författare)
Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands
van den Brandt, Piet A. (författare)
Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands
Wolk, Alicja (författare)
Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Stockholm, Sweden
Zeleniuch-Jacquotte, Anne (författare)
NYU, Sch Med, Dept Populat Hlth, New York, NY USA;NYU, Dept Environm Med, Sch Med, 550 1St Ave, New York, NY 10016 USA
Tworoger, Shelley S. (författare)
Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA;H Lee Moffitt Canc Ctr & Res Inst, Div Populat Sci, Tampa, FL USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
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 (creator_code:org_t)
AMER ASSOC CANCER RESEARCH, 2020
2020
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : AMER ASSOC CANCER RESEARCH. - 1055-9965 .- 1538-7755. ; 29:1, s. 200-207
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Laterality of epithelial ovarian tumors may reflect the underlying carcinogenic pathways and origins of tumor cells.Methods: We pooled data from 9 prospective studies participating in the Ovarian Cancer Cohort Consortium. Information on measures of tumor size or tumor dominance was extracted from surgical pathology reports or obtained through cancer registries. We defined dominant tumors as those restricted to one ovary or where the dimension of one ovary was at least twice as large as the other, and nondominant tumors as those with similar dimensions across the two ovaries or peritoneal tumors. Competing risks Cox models were used to examine whether associations with reproductive and hormonal risk factors differed by ovarian tumor dominance.Results: Of 1,058 ovarian cancer cases with tumor dominance information, 401 were left-dominant, 363 were right-dominant, and 294 were nondominant. Parity was more strongly inversely associated with risk of dominant than nondominant ovarian cancer (P-heterogeneity = 0.004). Ever use of oral contraceptives (OC) was associated with lower risk of dominant tumors, but was not associated with nondominant tumors (Pheterogeneity = 0.01). Higher body mass index was associated with higher risk of left-dominant tumors, but not significantly associated with risk of right-dominant or nondominant tumors (P-heterogeneity = 0.08).Conclusions: These data suggest that reproductive and hormonal risk factors appear to have a stronger impact on dominant tumors, which may have an ovarian or endometriosis origin.Impact: Examining the associations of ovarian cancer risk factors by tumor dominance may help elucidate the mechanisms through which these factors influence ovarian cancer risk.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

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