Search: WFRF:(Caligo Maria A) >
Exploring the link ...
Exploring the link between MORF4L1 and risk of breast cancer
-
- Martrat, Griselda (author)
- IDIBELL,University Med Centre Utrecht
-
- Maxwell, Christopher A. (author)
- IDIBELL
-
- Tominaga, Emiko (author)
- University of Texas Health Science Centre San Antonio
-
show more...
-
- Porta-de-la-Riva, Montserrat (author)
- Chemoresistance and Predictive Factors of Tumor Response and Stromal Microenvironment, IDIBELL, Spain
-
- Bonifaci, Nuria (author)
- IDIBELL
-
- Gomez-Baldo, Laia (author)
- IDIBELL
-
- Bogliolo, Massimo (author)
- Autonomous University Barcelona
-
- Lazaro, Conxi (author)
- IDIBELL
-
- Blanco, Ignacio (author)
- IDIBELL
-
- Brunet, Joan (author)
- Hospital Josep Trueta
-
- Aguilar, Helena (author)
- Bellvitge Institute Biomed Research IDIBELL
-
- Fernandez-Rodriguez, Juana (author)
- IDIBELL
-
- Seal, Sheila (author)
- Institute Canc Research
-
- Renwick, Anthony (author)
- Institute Canc Research
-
- Rahman, Nazneen (author)
- Institute Canc Research
-
- Kuehl, Julia (author)
- Department of Human Genetics, University of Würzburg, Biozentrum, Am Hubland, Würzburg, Germany
-
- Neveling, Kornelia (author)
- University Wurzburg
-
- Schindler, Detlev (author)
- University Wurzbur
-
- Ramirez, Maria J. (author)
- Autonomous University Barcelona
-
- Castella, Maria (author)
- Autonomous University Barcelon
-
- Hernandez, Gonzalo (author)
- Autonomous University Barcelona
-
- Easton, Douglas F. (author)
- University Cambridge,Newcastle Upon Tyne Hospital NHS Trust
-
- Peock, Susan (author)
- University Cambridge
-
- Cook, Margaret (author)
- University Cambridge
-
- Oliver, Clare T. (author)
- University Cambridge
-
- Frost, Debra (author)
- University Cambridge
-
- Platte, Radka (author)
- University Cambridge
-
- Evans, D. Gareth (author)
- Cent Manchester University Hospital NHS Fdn Trust
-
- Lalloo, Fiona (author)
- Cent Manchester University Hospital NHS Fdn Trust
-
- Eeles, Rosalind (author)
- Institute Canc Research, Oncogenet Team
-
- Izatt, Louise (author)
- Guys and St Thomas NHS Fdn Trust
-
- Chu, Carol (author)
- St James Hospital,University Cambridge
-
- Davidson, Rosemarie (author)
- Ferguson Smith Centre Clin Genet
-
- Ong, Kai-Ren (author)
- Birmingham Womens Hospital Healthcare NHS Trust
-
- Cook, Jackie (author)
- Sheffield Childrens Hospital
-
Douglas, Fiona (author)
-
- Hodgson, Shirley (author)
- University London
-
- Brewer, Carole (author)
- Royal Devon and Exeter Hospital
-
- Morrison, Patrick J. (author)
- Belfast City Hospital
-
- Porteous, Mary (author)
- Western Gen Hospital
-
- Peterlongo, Paolo (author)
- Fdn IRCCS Ist Nazl Tumori INT,Leiden University
-
- Manoukian, Siranoush (author)
- Fdn IRCCS INT
-
- Peissel, Bernard (author)
- Fdn IRCCS INT
-
- Zaffaroni, Daniela (author)
- Fdn IRCCS INT
-
- Roversi, Gaia (author)
- Fdn IRCCS INT
-
- Barile, Monica (author)
- Ist Europeo Oncol IEO
-
- Viel, Alessandra (author)
- IRCCS
-
- Pasini, Barbara (author)
- University Turin
-
- Ottini, Laura (author)
- University Roma La Sapienza
-
- Putignano, Anna Laura (author)
- Fiorgen Fdn Pharmacogen
-
- Savarese, Antonella (author)
- Regina Elena Institute Canc Research
-
- Bernard, Loris (author)
- IEO,Netherlands Canc Institute
-
- Radice, Paolo (author)
- Fdn IRCCS Ist Nazl Tumori INT
-
- Healey, Sue (author)
- Queensland Institute Med Research
-
- Spurdle, Amanda (author)
- Queensland Institute Med Research
-
- Chen, Xiaoqing (author)
- Queensland Institute Med Research
-
- Beesley, Jonathan (author)
- Queensland Institute Med Research
-
- Rookus, Matti A. (author)
- Netherlands Canc Institute
-
- Verhoef, Senno (author)
- Netherlands Canc Institute
-
- Tilanus-Linthorst, Madeleine A. (author)
- Erasmus MC Daniel den Hoed Canc Centre
-
Vreeswijk, Maaike P. (author)
-
- Asperen, Christi J. (author)
- Leiden University
-
- Bodmer, Danielle (author)
- Radboud University Nijmegen
-
Ausems, Margreet G. E. M. (author)
-
- van Os, Theo A. (author)
- University Amsterdam
-
- Blok, Marinus J. (author)
- University Hospital Maastricht
-
- Meijers-Heijboer, Hanne E. J. (author)
- Vrije University Amsterdam Med Centre,Canc Prevent Institute Calif
-
Hogervorst, Frans B. L. (author)
-
- Goldgar, David E. (author)
- University Utah
-
- Buys, Saundra (author)
- Huntsman Canc Institute
-
John, Esther M. (author)
-
- Miron, Alexander (author)
- Harvard University
-
- Southey, Melissa (author)
- University Melbourne
-
- Daly, Mary B. (author)
- Fox Chase Canc Centre
-
- Harbst, Katja (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skane University Hospital
-
- Borg, Åke (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skane University Hospital
-
- Rantala, Johanna (author)
- Karolinska Institutet,Karolinska University Hospital
-
- Barbany-Bustinza, Gisela (author)
- Karolinska Institutet,Karolinska University Hospital
-
- Ehrencrona, Hans (author)
- Uppsala universitet,Uppsala University,Institutionen för immunologi, genetik och patologi
-
- Stenmark Askmalm, Marie (author)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Klinisk patologi och klinisk genetik
-
- Kaufman, Bella (author)
- The Institute of Oncology, Chaim Sheba Medical Center, Israel
-
- Laitman, Yael (author)
- Chaim Sheba Med Centre
-
- Milgrom, Roni (author)
- Chaim Sheba Med Centre
-
- Friedman, Eitan (author)
- Chaim Sheba Med Centre
-
- Domchek, Susan M. (author)
- University Penn
-
- Nathanson, Katherine L. (author)
- University Penn
-
- Rebbeck, Timothy R. (author)
- University Penn
-
- Johannsson, Oskar Thor (author)
- Department of Oncology, 20A Landspitali-LSH v/Hringbraut, Reykjavik, Iceland
-
- Couch, Fergus J. (author)
- Mayo Clin
-
- Wang, Xianshu (author)
- Mayo Clin
-
- Fredericksen, Zachary (author)
- Mayo Clin
-
- Cuadras, Daniel (author)
- IDIBELL
-
- Moreno, Vctor (author)
- IDIBELL
-
- Pientka, Friederike K. (author)
- University Lubeck
-
- Depping, Reinhard (author)
- University Lubeck
-
- Caldes, Trinidad (author)
- Hospital Clin San Carlos
-
- Osorio, Ana (author)
- Spanish Natl Canc Research Centre
-
- Benitez, Javier (author)
- Spanish Natl Canc Research Centre
-
- Bueren, Juan (author)
- Centre Invest Energet Medioambientales and Tecnol CIEM,
-
- Heikkinen, Tuomas (author)
- University Helsinki
-
- Nevanlinna, Heli (author)
- University Helsinki
-
- Hamann, Ute (author)
- Deutsch Krebsforschungszentrum DKFZ
-
- Torres, Diana (author)
- Pontificia University Javeriana
-
- Caligo, Maria Adelaide (author)
- University Hospital Pisa
-
- Godwin, Andrew K. (author)
- University Kansas
-
- Imyanitov, Evgeny N. (author)
- NN Petrov Oncol Research Institute
-
- Janavicius, Ramunas (author)
- Vilnius University Hospital
-
- Sinilnikova, Olga M. (author)
- University Lyon 1
-
- Stoppa-Lyonnet, Dominique (author)
- Institute Curie
-
- Mazoyer, Sylvie (author)
- University Lyon 1
-
- Verny-Pierre, Carole (author)
- University Lyon 1
-
- Castera, Laurent (author)
- Institute Curie
-
- de Pauw, Antoine (author)
- Institute Curie
-
- Bignon, Yves-Jean (author)
- University Clermont Ferrand
-
- Uhrhammer, Nancy (author)
- University Clermont Ferrand
-
- Peyrat, Jean-Philippe (author)
- Centre Oscar Lambret
-
- Vennin, Philippe (author)
- Consultation d'Oncogénétique, Centre Oscar Lambret, Lille, France
-
- Ferrer, Sandra Fert (author)
- Hotel Dieu Centre Hospital
-
- Collonge-Rame, Marie-Agnes (author)
- CHU Besancon
-
- Mortemousque, Isabelle (author)
- CHU Bretonneau
-
- McGuffog, Lesley (author)
- University Cambridge
-
- Chenevix-Trench, Georgia (author)
- Queensland Institute Med Research
-
- Pereira-Smith, Olivia M. (author)
- University Texas Hlth Science Centre San Antonio
-
Antoniou, Antonis C. (author)
-
- Ceron, Julian (author)
- IDIBELL
-
- Tominaga, Kaoru (author)
- University Texas Hlth Science Centre San Antonio
-
- Surralles, Jordi (author)
- Autonomous University Barcelona
-
- Angel Pujana, Miguel (author)
- Catalan Institute of Oncology, IDIBELL, Spain
-
show less...
-
(creator_code:org_t)
- 2011-04-05
- 2011
- English.
-
In: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 13:2
- Related links:
-
https://portal.resea... (primary) (free)
-
show more...
-
http://dx.doi.org/10... (free)
-
http://www.ncbi.nlm.... (free)
-
http://dx.doi.org/10... (free)
-
https://breast-cance...
-
https://liu.diva-por... (primary) (Raw object)
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens. Methods: Protein physical interactions were screened using the yeast two-hybrid system. Co-affinity purifications and endogenous co-immunoprecipitation assays were performed to corroborate interactions. Biochemical and functional assays in human, mouse and Caenorhabditis elegans models were carried out to characterize pathway components. Thirteen FANCD2-monoubiquitinylation-positive FA cell lines excluded for genetic defects in the downstream pathway components and 300 familial BrCa patients negative for BRCA1/2 mutations were analyzed for genetic mutations. Common genetic variants were genotyped in 9,573 BRCA1/2 mutation carriers for associations with BrCa risk. Results: A previously identified co-purifying protein with PALB2 was identified, MRG15 (MORF4L1 gene). Results in human, mouse and C. elegans models delineate molecular and functional relationships with BRCA2, PALB2, RAD51 and RPA1 that suggest a role for MRG15 in the repair of DNA double-strand breaks. Mrg15-deficient murine embryonic fibroblasts showed moderate sensitivity to g-irradiation relative to controls and reduced formation of Rad51 nuclear foci. Examination of mutants of MRG15 and BRCA2 C. elegans orthologs revealed phenocopy by accumulation of RPA-1 (human RPA1) nuclear foci and aberrant chromosomal compactions in meiotic cells. However, no alterations or mutations were identified for MRG15/MORF4L1 in unclassified FA patients and BrCa familial cases. Finally, no significant associations between common MORF4L1 variants and BrCa risk for BRCA1 or BRCA2 mutation carriers were identified: rs7164529, P-trend = 0.45 and 0.05, P-2df = 0.51 and 0.14, respectively; and rs10519219, P-trend = 0.92 and 0.72, P-2df = 0.76 and 0.07, respectively. Conclusions: While the present study expands on the role of MRG15 in the control of genomic stability, weak associations cannot be ruled out for potential low-penetrance variants at MORF4L1 and BrCa risk among BRCA2 mutation carriers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Rad51 Recombinase
- RNA Interference
- Nuclear Proteins
- Mutation
- Mice
- Humans
- Genetic Predisposition to Disease
- BRCA2
- BRCA1
- Genes
- Female
- Fanconi Anemia Complementation Group D2 Protein
- Fanconi Anemia
- DNA Repair
- DNA Damage
- Cell Line
- Caenorhabditis elegans
- Animals
- Breast Neoplasms
- Replication Protein A
- Risk Factors
- Transcription Factors
- Tumor Suppressor Proteins
- Two-Hybrid System Techniques
- MEDICINE
- TECHNOLOGY
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Martrat, Griseld ...
-
Maxwell, Christo ...
-
Tominaga, Emiko
-
Porta-de-la-Riva ...
-
Bonifaci, Nuria
-
Gomez-Baldo, Lai ...
-
show more...
-
Bogliolo, Massim ...
-
Lazaro, Conxi
-
Blanco, Ignacio
-
Brunet, Joan
-
Aguilar, Helena
-
Fernandez-Rodrig ...
-
Seal, Sheila
-
Renwick, Anthony
-
Rahman, Nazneen
-
Kuehl, Julia
-
Neveling, Kornel ...
-
Schindler, Detle ...
-
Ramirez, Maria J ...
-
Castella, Maria
-
Hernandez, Gonza ...
-
Easton, Douglas ...
-
Peock, Susan
-
Cook, Margaret
-
Oliver, Clare T.
-
Frost, Debra
-
Platte, Radka
-
Evans, D. Gareth
-
Lalloo, Fiona
-
Eeles, Rosalind
-
Izatt, Louise
-
Chu, Carol
-
Davidson, Rosema ...
-
Ong, Kai-Ren
-
Cook, Jackie
-
Douglas, Fiona
-
Hodgson, Shirley
-
Brewer, Carole
-
Morrison, Patric ...
-
Porteous, Mary
-
Peterlongo, Paol ...
-
Manoukian, Siran ...
-
Peissel, Bernard
-
Zaffaroni, Danie ...
-
Roversi, Gaia
-
Barile, Monica
-
Viel, Alessandra
-
Pasini, Barbara
-
Ottini, Laura
-
Putignano, Anna ...
-
Savarese, Antone ...
-
Bernard, Loris
-
Radice, Paolo
-
Healey, Sue
-
Spurdle, Amanda
-
Chen, Xiaoqing
-
Beesley, Jonatha ...
-
Rookus, Matti A.
-
Verhoef, Senno
-
Tilanus-Linthors ...
-
Vreeswijk, Maaik ...
-
Asperen, Christi ...
-
Bodmer, Danielle
-
Ausems, Margreet ...
-
van Os, Theo A.
-
Blok, Marinus J.
-
Meijers-Heijboer ...
-
Hogervorst, Fran ...
-
Goldgar, David E ...
-
Buys, Saundra
-
John, Esther M.
-
Miron, Alexander
-
Southey, Melissa
-
Daly, Mary B.
-
Harbst, Katja
-
Borg, Åke
-
Rantala, Johanna
-
Barbany-Bustinza ...
-
Ehrencrona, Hans
-
Stenmark Askmalm ...
-
Kaufman, Bella
-
Laitman, Yael
-
Milgrom, Roni
-
Friedman, Eitan
-
Domchek, Susan M ...
-
Nathanson, Kathe ...
-
Rebbeck, Timothy ...
-
Johannsson, Oska ...
-
Couch, Fergus J.
-
Wang, Xianshu
-
Fredericksen, Za ...
-
Cuadras, Daniel
-
Moreno, Vctor
-
Pientka, Frieder ...
-
Depping, Reinhar ...
-
Caldes, Trinidad
-
Osorio, Ana
-
Benitez, Javier
-
Bueren, Juan
-
Heikkinen, Tuoma ...
-
Nevanlinna, Heli
-
Hamann, Ute
-
Torres, Diana
-
Caligo, Maria Ad ...
-
Godwin, Andrew K ...
-
Imyanitov, Evgen ...
-
Janavicius, Ramu ...
-
Sinilnikova, Olg ...
-
Stoppa-Lyonnet, ...
-
Mazoyer, Sylvie
-
Verny-Pierre, Ca ...
-
Castera, Laurent
-
de Pauw, Antoine
-
Bignon, Yves-Jea ...
-
Uhrhammer, Nancy
-
Peyrat, Jean-Phi ...
-
Vennin, Philippe
-
Ferrer, Sandra F ...
-
Collonge-Rame, M ...
-
Mortemousque, Is ...
-
McGuffog, Lesley
-
Chenevix-Trench, ...
-
Pereira-Smith, O ...
-
Antoniou, Antoni ...
-
Ceron, Julian
-
Tominaga, Kaoru
-
Surralles, Jordi
-
Angel Pujana, Mi ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Breast Cancer Re ...
- By the university
-
Lund University
-
Karolinska Institutet
-
Uppsala University
-
Linköping University