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Intralymphatic Immunotherapy : Update and Unmet Needs.

Senti, Gabriela (författare)
Clinical Trials Center, University Hospital, Zurich, Switzerland
Freiburghaus, Andreas U. (författare)
Clinical Trials Center, University Hospital, Zurich, Switzerland
Larenas-Linnemann, Désirée (författare)
Hospital Médica Sur, Mexico City, Mexico
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Hoffmann, Hans Jürgen (författare)
Department of Clinical Medicine, Aarhus University, Denmark; Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Denmark
Patterson, Amber M. (författare)
ENT & Allergy Specialists of Northwest Ohio, USA
Klimek, Ludger (författare)
Center for Rhinology and Allergology, Germany
Di Bona, Danilo (författare)
Department of Emergency and Organ Transplantation, Chair and School of Allergology and Clinical Immunology, University of Bari – Aldo Moro, Italy
Pfaar, Oliver (författare)
Center for Rhinology and Allergology, Germany; Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany
Ahlbeck, Lars, 1964- (författare)
Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Allergicentrum US
Akdis, Mübeccel (författare)
Swiss Institute of Allergy and Asthma Research SIAF, Switzerland
Weinfeld, Dan (författare)
Asthma and Allergy Clinic (Adults), Department of Internal Medicine, South Alvsborgs (Central) Hospital, Sweden
Contreras-Verduzco, Francisco A. (författare)
Allergy Department, National Institute of Pediatrics, Mexico
Pedroza-Melendez, Alvaro (författare)
Allergy Department, National Institute of Pediatrics, Mexico
Skaarup, Søren H. (författare)
Department of Clinical Medicine – Department of Respiratory Diseases and Allergy, Aarhus University, Denmark
Lee, Sang Min (författare)
Division of Allergy and Pulmonology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Republic of Korea
Cardell, Lars-Olaf (författare)
Karolinska Institutet,Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Sweden
Schmid, Johannes M. (författare)
Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Denmark
Westin, Ulla (författare)
Division of Ear, Nose and Throat Diseases, Head and Neck Surgery, Department of Clinical Sciences, Lund University, Skane University Hospital, Sweden; Region Skane, Skane University Hospital, Sweden
Dollner, Ralph (författare)
Department Otorhinolaryngology – Head and Neck Surgery, Clinic for Head-Neck and Reconstructive Surgery, Oslo University Hospital (OUS) HF – Rikshospitalet, Oslo, Norway
Kündig, Thomas M. (författare)
Department of Dermatology, University Hospital Zurich, Switzerland
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 (creator_code:org_t)
2018-11-02
2019
Engelska.
Ingår i: International Archives of Allergy and Immunology. - : S. Karger. - 1018-2438 .- 1423-0097. ; 178:2, s. 141-149
Relaterad länk:
https://www.karger.c...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • Allergen-specific immunotherapy (AIT) is the only allergy treatment that confers long-term symptom amelioration for patients suffering from allergy. The most frequently used allergen application route is subcutaneous injection (SCIT), commonly taken as the gold standard, followed by sublingual (SLIT) or oral (OIT) application of allergen preparations. This is an up-to-date review of the clinical evidence for a novel route of allergen application, i.e., directly into lymph nodes - intralymphatic immunotherapy (ILIT). The major advantages of ILIT over the current AIT approaches are its short duration and the low allergen doses administered. The whole treatment consists of merely 3 ultrasound-guided injections into inguinal lymph nodes 1 month apart. While the number of patients included in randomised controlled trials is still limited, the clinical results for ILIT are encouraging, but more clinical trials are needed, as well as more preclinical work for optimising formulations.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

Allergen-specific immunotherapy
Allergy
Clinical trials
Intralymphatic immunotherapy

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