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WFRF:(Carlson Joseph W.)
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High density of stroma-localized CD11c-positive macrophages is associated with longer overall survival in high-grade serous ovarian cancer.
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- Corvigno, Sara (författare)
- Uppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Karolinska University Hospital,Karolinska Inst, Sweden; Uppsala Univ, Sweden
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- Mezheyeuski, Artur (författare)
- Uppsala University,Uppsala universitet,Experimentell och klinisk onkologi,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Karolinska University Hospital,Karolinska Inst, Sweden; Uppsala Univ, Sweden
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- De La Fuente, Laura Martin (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Elsevier BV, 2020
- 2020
- Engelska.
- Ingår i: Gynecologic Oncology. - : Elsevier BV. - 0090-8258 .- 1095-6859. ; 159:3, s. 860-868
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- OBJECTIVE: Pre-clinical studies have identified marker- and tumor compartment-defined functionally distinct macrophage subsets. Our study analyzes marker-defined macrophage subsets in different tumor compartments of high-grade serous ovarian cancer (HGSC).METHODS: A discovery cohort (N = 113) was subjected to immunohistochemistry (IHC) analyses. CD68-positivity was confirmed for CD11c-, CD80- and CD163-positive cells. Subset-marker-positive cells were scored in the total tumor and in four tumor compartments. Correlation analyses investigated co-expression of subsets, relationship to CD8+ cells and survival associations. A validation cohort (N = 121) was used to confirm selected findings from the discovery cohort.RESULTS: CD163-positve cells was the most abundant subtype in all compartments. CD11c and CD163 subsets were strongly correlated with each other in stroma and epithelial areas, whereas CD80 and CD163 were correlated in epithelial areas. CD80 and CD11c in perivascular areas showed low correlations. Strong associations were detected between CD8 and CD80 in the tumor epithelium-dominated areas, and between CD8 and CD11c in stroma areas. High stromal CD11c density was associated with a longer median overall survival in the discovery cohort (HR 0.39; CI 95%, 0.23-0.68; p = 0.001) and in the validation cohort (HR 0.46; CI 95%, 0.22-0.93; p = 0.03).CONCLUSIONS: Our study supports the existence of clinically relevant marker- and localization defined macrophage subsets in HGSC, which are independently regulated. Moreover, it suggests stromal CD11c as a novel prognostic marker in HGSC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- High-grade serous ovarian cancer
- Overall survival
- Tumor immunology
- Tumor microenvironment
- Tumor-associated macrophages
- Oncology
- Onkologi
- High-grade serous ovarian cancer
- Overall survival
- Tumor immunology
- Tumor microenvironment
- Tumor-associated macrophages
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