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Search: WFRF:(Carson Joseph) > A genome-wide scan ...

A genome-wide scan for common alleles affecting risk for autism.

Anney, Richard (author)
Klei, Lambertus (author)
Pinto, Dalila (author)
show more...
Regan, Regina (author)
Conroy, Judith (author)
Magalhaes, Tiago R (author)
Correia, Catarina (author)
Abrahams, Brett S (author)
Sykes, Nuala (author)
Pagnamenta, Alistair T (author)
Almeida, Joana (author)
Bacchelli, Elena (author)
Bailey, Anthony J (author)
Baird, Gillian (author)
Battaglia, Agatino (author)
Berney, Tom (author)
Bolshakova, Nadia (author)
Bölte, Sven (author)
Bolton, Patrick F. (author)
Bourgeron, Thomas (author)
Brennan, Sean (author)
Brian, Jessica (author)
Carson, Andrew R (author)
Casallo, Guillermo (author)
Casey, Jillian (author)
Chu, Su H (author)
Cochrane, Lynne (author)
Corsello, Christina (author)
Crawford, Emily L (author)
Crossett, Andrew (author)
Dawson, Geraldine (author)
de Jonge, Maretha (author)
Delorme, Richard (author)
Drmic, Irene (author)
Duketis, Eftichia (author)
Duque, Frederico (author)
Estes, Annette (author)
Farrar, Penny (author)
Fernandez, Bridget A (author)
Folstein, Susan E (author)
Fombonne, Eric (author)
Freitag, Christine M (author)
Gilbert, John (author)
Gillberg, Christopher, 1950 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Glessner, Joseph T (author)
Goldberg, Jeremy (author)
Green, Jonathan (author)
Guter, Stephen J (author)
Hakonarson, Hakon (author)
Heron, Elizabeth A (author)
Hill, Matthew (author)
Holt, Richard (author)
Howe, Jennifer L (author)
Hughes, Gillian (author)
Hus, Vanessa (author)
Igliozzi, Roberta (author)
Kim, Cecilia (author)
Klauck, Sabine M (author)
Kolevzon, Alexander (author)
Korvatska, Olena (author)
Kustanovich, Vlad (author)
Lajonchere, Clara M (author)
Lamb, Janine A (author)
Laskawiec, Magdalena (author)
Leboyer, Marion (author)
Le Couteur, Ann (author)
Leventhal, Bennett L (author)
Lionel, Anath C (author)
Liu, Xiao-Qing (author)
Lord, Catherine (author)
Lotspeich, Linda (author)
Lund, Sabata C (author)
Maestrini, Elena (author)
Mahoney, William (author)
Mantoulan, Carine (author)
Marshall, Christian R (author)
McConachie, Helen (author)
McDougle, Christopher J (author)
McGrath, Jane (author)
McMahon, William M (author)
Melhem, Nadine M (author)
Merikangas, Alison (author)
Migita, Ohsuke (author)
Minshew, Nancy J (author)
Mirza, Ghazala K (author)
Munson, Jeff (author)
Nelson, Stanley F (author)
Noakes, Carolyn (author)
Noor, Abdul (author)
Nygren, Gudrun, 1957 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Oliveira, Guiomar (author)
Papanikolaou, Katerina (author)
Parr, Jeremy R (author)
Parrini, Barbara (author)
Paton, Tara (author)
Pickles, Andrew (author)
Piven, Joseph (author)
Posey, David J (author)
Poustka, Annemarie (author)
Poustka, Fritz (author)
Prasad, Aparna (author)
Ragoussis, Jiannis (author)
Renshaw, Katy (author)
Rickaby, Jessica (author)
Roberts, Wendy (author)
Roeder, Kathryn (author)
Roge, Bernadette (author)
Rutter, Michael L (author)
Bierut, Laura J (author)
Rice, John P (author)
Salt, Jeff (author)
Sansom, Katherine (author)
Sato, Daisuke (author)
Segurado, Ricardo (author)
Senman, Lili (author)
Shah, Naisha (author)
Sheffield, Val C (author)
Soorya, Latha (author)
Sousa, Inês (author)
Stoppioni, Vera (author)
Strawbridge, Christina (author)
Tancredi, Raffaella (author)
Tansey, Katherine (author)
Thiruvahindrapduram, Bhooma (author)
Thompson, Ann P (author)
Thomson, Susanne (author)
Tryfon, Ana (author)
Tsiantis, John (author)
Van Engeland, Herman (author)
Vincent, John B (author)
Volkmar, Fred (author)
Wallace, Simon (author)
Wang, Kai (author)
Wang, Zhouzhi (author)
Wassink, Thomas H (author)
Wing, Kirsty (author)
Wittemeyer, Kerstin (author)
Wood, Shawn (author)
Yaspan, Brian L (author)
Zurawiecki, Danielle (author)
Zwaigenbaum, Lonnie (author)
Betancur, Catalina (author)
Buxbaum, Joseph D (author)
Cantor, Rita M (author)
Cook, Edwin H (author)
Coon, Hilary (author)
Cuccaro, Michael L (author)
Gallagher, Louise (author)
Geschwind, Daniel H (author)
Gill, Michael (author)
Haines, Jonathan L (author)
Miller, Judith (author)
Monaco, Anthony P (author)
Nurnberger, John I (author)
Paterson, Andrew D (author)
Pericak-Vance, Margaret A (author)
Schellenberg, Gerard D (author)
Scherer, Stephen W (author)
Sutcliffe, James S (author)
Szatmari, Peter (author)
Vicente, Astrid M (author)
Vieland, Veronica J (author)
Wijsman, Ellen M (author)
Devlin, Bernie (author)
Ennis, Sean (author)
Hallmayer, Joachim (author)
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 (creator_code:org_t)
2010-07-27
2010
English.
In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 19:20, s. 4072-4082
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10(-8). When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10(-8) threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Alleles
Autistic Disorder
Genetics
DNA Copy Number Variations
Databases
Genetic
European Continental Ancestry Group
Genetics
Genetic Predisposition to Disease
Genetic Variation
Genome
Human
Genome-Wide Association Study
Genotype
Humans
Polymorphism
Single Nucleotide
Risk Factors

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Anney, Richard
Klei, Lambertus
Pinto, Dalila
Regan, Regina
Conroy, Judith
Magalhaes, Tiago ...
show more...
Correia, Catarin ...
Abrahams, Brett ...
Sykes, Nuala
Pagnamenta, Alis ...
Almeida, Joana
Bacchelli, Elena
Bailey, Anthony ...
Baird, Gillian
Battaglia, Agati ...
Berney, Tom
Bolshakova, Nadi ...
Bölte, Sven
Bolton, Patrick ...
Bourgeron, Thoma ...
Brennan, Sean
Brian, Jessica
Carson, Andrew R
Casallo, Guiller ...
Casey, Jillian
Chu, Su H
Cochrane, Lynne
Corsello, Christ ...
Crawford, Emily ...
Crossett, Andrew
Dawson, Geraldin ...
de Jonge, Mareth ...
Delorme, Richard
Drmic, Irene
Duketis, Eftichi ...
Duque, Frederico
Estes, Annette
Farrar, Penny
Fernandez, Bridg ...
Folstein, Susan ...
Fombonne, Eric
Freitag, Christi ...
Gilbert, John
Gillberg, Christ ...
Glessner, Joseph ...
Goldberg, Jeremy
Green, Jonathan
Guter, Stephen J
Hakonarson, Hako ...
Heron, Elizabeth ...
Hill, Matthew
Holt, Richard
Howe, Jennifer L
Hughes, Gillian
Hus, Vanessa
Igliozzi, Robert ...
Kim, Cecilia
Klauck, Sabine M
Kolevzon, Alexan ...
Korvatska, Olena
Kustanovich, Vla ...
Lajonchere, Clar ...
Lamb, Janine A
Laskawiec, Magda ...
Leboyer, Marion
Le Couteur, Ann
Leventhal, Benne ...
Lionel, Anath C
Liu, Xiao-Qing
Lord, Catherine
Lotspeich, Linda
Lund, Sabata C
Maestrini, Elena
Mahoney, William
Mantoulan, Carin ...
Marshall, Christ ...
McConachie, Hele ...
McDougle, Christ ...
McGrath, Jane
McMahon, William ...
Melhem, Nadine M
Merikangas, Alis ...
Migita, Ohsuke
Minshew, Nancy J
Mirza, Ghazala K
Munson, Jeff
Nelson, Stanley ...
Noakes, Carolyn
Noor, Abdul
Nygren, Gudrun, ...
Oliveira, Guioma ...
Papanikolaou, Ka ...
Parr, Jeremy R
Parrini, Barbara
Paton, Tara
Pickles, Andrew
Piven, Joseph
Posey, David J
Poustka, Annemar ...
Poustka, Fritz
Prasad, Aparna
Ragoussis, Jiann ...
Renshaw, Katy
Rickaby, Jessica
Roberts, Wendy
Roeder, Kathryn
Roge, Bernadette
Rutter, Michael ...
Bierut, Laura J
Rice, John P
Salt, Jeff
Sansom, Katherin ...
Sato, Daisuke
Segurado, Ricard ...
Senman, Lili
Shah, Naisha
Sheffield, Val C
Soorya, Latha
Sousa, Inês
Stoppioni, Vera
Strawbridge, Chr ...
Tancredi, Raffae ...
Tansey, Katherin ...
Thiruvahindrapdu ...
Thompson, Ann P
Thomson, Susanne
Tryfon, Ana
Tsiantis, John
Van Engeland, He ...
Vincent, John B
Volkmar, Fred
Wallace, Simon
Wang, Kai
Wang, Zhouzhi
Wassink, Thomas ...
Wing, Kirsty
Wittemeyer, Kers ...
Wood, Shawn
Yaspan, Brian L
Zurawiecki, Dani ...
Zwaigenbaum, Lon ...
Betancur, Catali ...
Buxbaum, Joseph ...
Cantor, Rita M
Cook, Edwin H
Coon, Hilary
Cuccaro, Michael ...
Gallagher, Louis ...
Geschwind, Danie ...
Gill, Michael
Haines, Jonathan ...
Miller, Judith
Monaco, Anthony ...
Nurnberger, John ...
Paterson, Andrew ...
Pericak-Vance, M ...
Schellenberg, Ge ...
Scherer, Stephen ...
Sutcliffe, James ...
Szatmari, Peter
Vicente, Astrid ...
Vieland, Veronic ...
Wijsman, Ellen M
Devlin, Bernie
Ennis, Sean
Hallmayer, Joach ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Psychiatry
Articles in the publication
Human Molecular ...
By the university
University of Gothenburg

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