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Sökning: onr:"swepub:oai:DiVA.org:oru-110156" > Comprehensive mappi...

Comprehensive mapping review of real-world evidence publications focusing on targeted therapies in solid tumors : A collaborative work from ESMO real-world data and Digital Health Working Group

Pellat, A. (författare)
Gastroenterology and digestive oncology Department, Hôpital Cochin, Paris, France
Grinda, T. (författare)
Medical Oncology Dept., Institut Gustave Roussy, Villejuif, France
Prelaj, A. (författare)
Department of Medical Oncology, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy
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Cresta, P. (författare)
Medical Oncology Dept., VHIO - Vall d’Hebron Institute of Oncology, Barcelona, Spain
Valachis, A, 1984- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Dpt. of Oncology
Zerdes, I. (författare)
Oncology-Pathology Department, Karolinska Institutet - Bioclinicum, Solna, Sweden
Branco, D. Martins (författare)
Academic Trials Promoting Team (ATPT), Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), Institut Jules Bordet, Brussels, Belgium
Provenzano, L. (författare)
Department of Medical Oncology, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy
Spagnoletti, A. (författare)
Department of Medical Oncology, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy
Marta, G. Nader (författare)
Academic Trials Promoting Team (ATPT), Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), Institut Jules Bordet, Brussels, Belgium
Wilson, B. (författare)
Department of Oncology, Queen's University, Kingston ON, Canada
Montemurro, F. (författare)
Investigative Clinical Oncology dept., IRCCS - Istituto di Candiolo - FPO, Turin, Italy
Castelo-Branco, L. (författare)
Scientific and Medical Division, ESMO - European Society for Medical Oncology, Lugano, Switzerland
Pentheroudakis, G. (författare)
Scientific and Medical Division, ESMO - European Society for Medical Oncology, Lugano, Switzerland
Delaloge, S. (författare)
Breast Oncology Department, Institut Gustave Roussy, Villejuif, France
Koopman, M. (författare)
Medical Oncology Department, UMC - University Medical Center Utrecht, Utrecht, Netherlands
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Gastroenterology and digestive oncology Department, Hôpital Cochin, Paris, France Medical Oncology Dept, Institut Gustave Roussy, Villejuif, France (creator_code:org_t)
Elsevier, 2023
2023
Engelska.
Ingår i: Annals of Oncology. - : Elsevier. - 0923-7534 .- 1569-8041. ; 34:Suppl. 2, s. S925-S925
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
Abstract Ämnesord
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  • Background: A growing body of real-world evidence (RWE) aims to better reflect outcomes of cancer patients treated in real-world settings. We aimed to conduct a first comprehensive mapping review of the RWE produced over the past 3 years in terms of tumor type, treatment strategies, setting, and data sources, focusing on targeted therapies (TT) in solid tumors.Methods: We conducted a systematic review in PubMed of RWE studies published between 01/2020 and 12/2022. We identified non-interventional studies using observational data, focusing on solid tumors exposure to targeted therapies, excluding immunotherapies. Abstract and full-text screening were performed by 11 independent reviewers.Results: A total of 7,774 publications were retrieved with 1,251 considered eligible and extracted. The number of publications per year progressively increased during this period (328 in 2020; 421 in 2021; 502 in 2022). Most studies (50%) were performed in Asia, followed by Europe (25%) and North America (17%). Only 8% of studies had patients treated in more than one country. Treatment effectiveness and safety were assessed in 71% and 42% of studies respectively. Main data sources were medical records.Conclusions: RWE publications on TT for solid tumors are heterogeneous and mostly rely on retrospective data such as medical records. Population-based and international studies are rare. Collaborative efforts towards international representativeness and the use of routinely collected and/or standardized data sources must be encouraged to increase the relevance and future quality of publications and their potential impact on oncology practice.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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