Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies

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Low Free Testosterone and Prostate Cancer Risk : A Collaborative Analysis of 20 Prospective Studies

Watts, Eleanor L. (författare): Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England

Appleby, Paul N. (författare): Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England

Perez-Cornago, Aurora (författare): Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England

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Bueno-de-Mesquita, H. Bas (författare): Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis, Bilthoven, Netherlands;Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands;Imperial Coll London, Dept Epidemiol & Biostat, London, England;Univ Malaya, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

Chan, June M. (författare): Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA;Univ Calif San Francisco, Dept Urol, San Francisco, CA USA

Chen, Chu (författare): Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA

Cohn, Barbara A. (författare): Publ Hlth Inst, Child Hlth & Dev Studies, Berkeley, CA USA

Cook, Michael B. (författare): US Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD USA

Flicker, Leon (författare): Univ Western Australia, Sch Med, Perth, WA, Australia;Univ Western Australia, Med Res Ctr, Western Australian Ctr Hlth & Ageing, Perth, WA, Australia

Freedman, Neal D. (författare): US Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD USA

Giles, Graham G. (författare): Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia

Giovannucci, Edward (författare): Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA USA;Publ Hlth Directorate, Asturias, Spain;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

Gislefoss, Randi E. (författare): Inst Epidemiol Canc Res, Canc Registry Norway, Oslo, Norway

Hankey, Graeme J. (författare): Univ Western Australia, Sch Med, Perth, WA, Australia

Kaaks, Rudolf (författare): German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

Knekt, Paul (författare): Natl Inst Hlth & Welf, Helsinki, Finland

Kolonel, Laurence N. (författare): Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA

Kubo, Tatsuhiko (författare): Univ Occupat & Environm Hlth, Dept Prevent Med & Community Hlth, Kitakyushu, Fukuoka, Japan

Le Marchand, Loic (författare): Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA

Luben, Robert N. (författare): Univ Cambridge, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge, England

Luostarinen, Tapio (författare): Inst Stat & Epidemiol Canc Res, Finnish Canc Registry, Helsinki, Finland

Mannisto, Satu (författare): Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland

Metter, E. Jeffrey (författare): Univ Tennessee, Ctr Hlth Sci, Dept Neurol, Memphis, TN 38163 USA

Mikami, Kazuya (författare): Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Urol, Kyoto, Japan

Milne, Roger L. (författare): Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia

Ozasa, Kotaro (författare): Radiat Effects Res Fdn, Dept Epidemiol, Hiroshima, Japan

Platz, Elizabeth A. (författare): Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

Quiros, J. Ramon (författare): Publ Hlth Directorate, Asturias, Spain

Rissanen, Harri (författare): Natl Inst Hlth & Welf, Helsinki, Finland

Sawada, Norie (författare): Natl Canc Ctr, Epidemiol & Prevent Grp, Ctr Publ Hlth Sci, Tokyo, Japan

Stampfer, Meir (författare): Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA USA

Stanczyk, Frank Z. (författare): Univ Southern Calif, Keck Sch Med, Div Reprod Endocrinol & Infertil, Los Angeles, CA USA

Stattin, Pär (författare): Uppsala universitet,Urologkirurgi

Tamakoshi, Akiko (författare): Hokkaido Univ, Grad Sch Med, Dept Publ Hlth, Sapporo, Hokkaido, Japan

Tangen, Catherine M. (författare): Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA

Thompson, Ian M. (författare): Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA

Tsilidis, Konstantinos K. (författare): Imperial Coll London, Dept Epidemiol & Biostat, London, England;Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece

Tsugane, Shoichiro (författare): Natl Canc Ctr, Epidemiol & Prevent Grp, Ctr Publ Hlth Sci, Tokyo, Japan

Ursin, Giske (författare): Inst Epidemiol Canc Res, Canc Registry Norway, Oslo, Norway;Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway;Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA

Vatten, Lars (författare): Norwegian Univ Sci & Technol, Fac Med, Dept Publ Hlth, Trondheim, Norway

Weiss, Noel S. (författare): Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA

Yeap, Bu B. (författare): Univ Western Australia, Sch Med, Perth, WA, Australia;Fiona Stanley Hosp, Dept Endocrinol & Diabet, Perth, WA, Australia

Allen, Naomi E. (författare): Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England

Key, Timothy J. (författare): Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England

Travis, Ruth C. (författare): Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England

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(creator_code:org_t)

Elsevier, 2018
2018
Engelska.
Ingår i: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560. ; 74:5, s. 585-594

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

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Background: Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting. Objective: To examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer. Design, setting, and participants: Analysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. Outcome measurements and statistical analysis: Odds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration. Results and limitations: Men in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR = 0.77, 95% confidence interval [CI] 0.69-0.86; p < 0.001) compared with men with higher concentrations (2nd-10th tenths of the distribution). Heterogeneity was present by tumour grade (p(het) = 0.01), with a lower risk of low-grade disease (OR = 0.76, 95% CI 0.67-0.88) and a nonsignificantly higher risk of high-grade disease (OR = 1.56, 95% CI 0.95-2.57). There was no evidence of heterogeneity by tumour stage. The observational design is a limitation. Conclusions: Men with low circulating free testosterone may have a lower risk of overall prostate cancer; this may be due to a direct biological effect, or detection bias. Further research is needed to explore the apparent differential association by tumour grade. Patient summary: In this study, we looked at circulating testosterone levels and risk of developing prostate cancer, finding that men with low testosterone had a lower risk of prostate cancer. (c) 2018 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology.

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Av författaren/redakt...: Watts, Eleanor L ...; Appleby, Paul N.; Perez-Cornago, A ...; Bueno-de-Mesquit ...; Chan, June M.; Chen, Chu; visa fler...; Cohn, Barbara A.; Cook, Michael B.; Flicker, Leon; Freedman, Neal D ...; Giles, Graham G.; Giovannucci, Edw ...; Gislefoss, Randi ...; Hankey, Graeme J ...; Kaaks, Rudolf; Knekt, Paul; Kolonel, Laurenc ...; Kubo, Tatsuhiko; Le Marchand, Loi ...; Luben, Robert N.; Luostarinen, Tap ...; Mannisto, Satu; Metter, E. Jeffr ...; Mikami, Kazuya; Milne, Roger L.; Ozasa, Kotaro; Platz, Elizabeth ...; Quiros, J. Ramon; Rissanen, Harri; Sawada, Norie; Stampfer, Meir; Stanczyk, Frank ...; Stattin, Pär; Tamakoshi, Akiko; Tangen, Catherin ...; Thompson, Ian M.; Tsilidis, Konsta ...; Tsugane, Shoichi ...; Ursin, Giske; Vatten, Lars; Weiss, Noel S.; Yeap, Bu B.; Allen, Naomi E.; Key, Timothy J.; Travis, Ruth C.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Urologi och njur ...

Artiklar i publikationen: European Urology

Av lärosätet: Uppsala universitet

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Low Free Testosterone and Prostate Cancer Risk : A Collaborative Analysis of 20 Prospective Studies

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