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A common coding variant in CASP8 is associated with breast cancer risk

Cox, Angela (author)
Dunning, Alison M. (author)
Garcia-Closas, Montserrat (author)
show more...
Balasubramanian, Sabapathy (author)
Reed, Malcolm W. R. (author)
Pooley, Karen A. (author)
Scollen, Serena (author)
Karolinska Institutet
Baynes, Caroline (author)
Ponder, Bruce A. J. (author)
Chanock, Stephen (author)
Lissowska, Jolanta (author)
Brinton, Louise (author)
Peplonska, Beata (author)
Southey, Melissa C. (author)
Hopper, John L. (author)
McCredie, Margaret R. E. (author)
Giles, Graham G. (author)
Fletcher, Olivia (author)
Johnson, Nichola (author)
dos Santos Silva, Isabel (author)
Gibson, Lorna (author)
Bojesen, Stig E. (author)
Nordestgaard, Børge G. (author)
Axelsson, Christen K. (author)
Torres, Diana (author)
Hamann, Ute (author)
Justenhoven, Christina (author)
Brauch, Hiltrud (author)
Chang-Claude, Jenny (author)
Kropp, Silke (author)
Risch, Angela (author)
Wang-Gohrke, Shan (author)
Schürmann, Peter (author)
Bogdanova, Natalia (author)
Dörk, Thilo (author)
Fagerholm, Rainer (author)
Aaltonen, Kirsimari (author)
Blomqvist, Carl (author)
Uppsala universitet,Enheten för onkologi
Nevanlinna, Heli (author)
Seal, Sheila (author)
Renwick, Anthony (author)
Stratton, Michael R. (author)
Rahman, Nazneen (author)
Sangrajrang, Suleeporn (author)
Hughes, David (author)
Odefrey, Fabrice (author)
Brennan, Paul (author)
Spurdle, Amanda B. (author)
Chenevix-Trench, Georgia (author)
Beesley, Jonathan (author)
Mannermaa, Arto (author)
Hartikainen, Jaana (author)
Kataja, Vesa (author)
Kosma, Veli-Matti (author)
Couch, Fergus J. (author)
Olson, Janet E. (author)
Goode, Ellen L. (author)
Broeks, Annegien (author)
Schmidt, Marjanka K. (author)
Hogervorst, Frans B. L. (author)
Van't Veer, Laura J. (author)
Kang, Daehee (author)
Yoo, Keun-Young (author)
Noh, Dong-Young (author)
Ahn, Sei-Hyun (author)
Wedrén, Sara (author)
Hall, Per (author)
Karolinska Institutet
Low, Yen-Ling (author)
Liu, Jianjun (author)
Milne, Roger L (author)
Ribas, Gloria (author)
Gonzalez-Neira, Anna (author)
Benitez, Javier (author)
Sigurdson, Alice J. (author)
Stredrick, Denise L. (author)
Alexander, Bruce H. (author)
Struewing, Jeffery P. (author)
Pharoah, Paul D. P. (author)
Easton, Douglas F. (author)
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 (creator_code:org_t)
2007-02-11
2007
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 39:3, s. 352-358
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with breast cancer. We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C --> A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3' UTR A --> G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 V301I (rs1056538) and NUMA1 A794G (rs3750913). We included data from 9-15 studies, comprising 11,391-18,290 cases and 14,753-22,670 controls. We found evidence of an association with breast cancer for CASP8 D302H (with odds ratios (OR) of 0.89 (95% confidence interval (c.i.): 0.85-0.94) and 0.74 (95% c.i.: 0.62-0.87) for heterozygotes and rare homozygotes, respectively, compared with common homozygotes; P(trend) = 1.1 x 10(-7)) and weaker evidence for TGFB1 L10P (OR = 1.07 (95% c.i.: 1.02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies.

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By the author/editor
Cox, Angela
Dunning, Alison ...
Garcia-Closas, M ...
Balasubramanian, ...
Reed, Malcolm W. ...
Pooley, Karen A.
show more...
Scollen, Serena
Baynes, Caroline
Ponder, Bruce A. ...
Chanock, Stephen
Lissowska, Jolan ...
Brinton, Louise
Peplonska, Beata
Southey, Melissa ...
Hopper, John L.
McCredie, Margar ...
Giles, Graham G.
Fletcher, Olivia
Johnson, Nichola
dos Santos Silva ...
Gibson, Lorna
Bojesen, Stig E.
Nordestgaard, Bø ...
Axelsson, Christ ...
Torres, Diana
Hamann, Ute
Justenhoven, Chr ...
Brauch, Hiltrud
Chang-Claude, Je ...
Kropp, Silke
Risch, Angela
Wang-Gohrke, Sha ...
Schürmann, Peter
Bogdanova, Natal ...
Dörk, Thilo
Fagerholm, Raine ...
Aaltonen, Kirsim ...
Blomqvist, Carl
Nevanlinna, Heli
Seal, Sheila
Renwick, Anthony
Stratton, Michae ...
Rahman, Nazneen
Sangrajrang, Sul ...
Hughes, David
Odefrey, Fabrice
Brennan, Paul
Spurdle, Amanda ...
Chenevix-Trench, ...
Beesley, Jonatha ...
Mannermaa, Arto
Hartikainen, Jaa ...
Kataja, Vesa
Kosma, Veli-Matt ...
Couch, Fergus J.
Olson, Janet E.
Goode, Ellen L.
Broeks, Annegien
Schmidt, Marjank ...
Hogervorst, Fran ...
Van't Veer, Laur ...
Kang, Daehee
Yoo, Keun-Young
Noh, Dong-Young
Ahn, Sei-Hyun
Wedrén, Sara
Hall, Per
Low, Yen-Ling
Liu, Jianjun
Milne, Roger L
Ribas, Gloria
Gonzalez-Neira, ...
Benitez, Javier
Sigurdson, Alice ...
Stredrick, Denis ...
Alexander, Bruce ...
Struewing, Jeffe ...
Pharoah, Paul D. ...
Easton, Douglas ...
show less...
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Nature Genetics
By the university
Uppsala University
Karolinska Institutet

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