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Comprehensive global genome dynamics of Chlamydia trachomatis show ancient diversification followed by contemporary mixing and recent lineage expansion

Hadfield, James (author)
Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Harris, Simon R (author)
Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Seth-Smith, Helena M B (author)
Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom; Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland; Clinical Microbiology, University Hospital Basel, Basel, Switzerland
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Parmar, Surendra (author)
Public Health England, Public Health Laboratory Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
Andersson, Patiyan (author)
Menzies School of Health Research, Darwin NT, Australia
Giffard, Philip M. (author)
Menzies School of Health Research, Darwin NT, Australia; School of Psychological and Clinical Sciences, Charles Darwin University, Darwin, Australia
Schachter, Julius (author)
Department of Laboratory Medicine, University of California, San Francisco CA, USA
Moncada, Jeanne (author)
Department of Laboratory Medicine, University of Californiao, San Francisco CA, USA
Ellison, Louise (author)
Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Vaulet, María Lucía Gallo (author)
Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica, Microbiología Clínica, Universidad de Buenos Aires, Buenos Aires, Argentina
Fermepin, Marcelo Rodríguez (author)
Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica, Microbiología Clínica, Universidad de Buenos Aires, Buenos Aires, Argentina
Radebe, Frans (author)
Centre for HIV and Sexually Transmitted Infections, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa
Mendoza, Suyapa (author)
Jefe Laboratorio de ITS, Laboratorio Nacional de Vigilancia, Honduras
Ouburg, Sander (author)
Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, Vrije University Medical Center, Amsterdam, The Netherlands
Morré, Servaas A (author)
Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, Vrije University Medical Center, Amsterdam, The Netherlands; Department of Genetics and Cell Biology, Institute of Public Health Genomics, School for Oncology & Developmental Biology (GROW), Faculty of Health, Medicine and Life Sciences, University of Maastricht, Maastricht, The Netherlands
Sachse, Konrad (author)
Institute of Molecular Pathogenesis, Friedrich-Loeffler-Institut (Federal Research Institute for Animal Health), Jena, Germany
Puolakkainen, Mirja (author)
Department of Virology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Korhonen, Suvi J (author)
Department of Virology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Sonnex, Chris (author)
Public Health England, Public Health Laboratory Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
Wiggins, Rebecca (author)
Department of Biology, University of York, York, United Kingdom
Jalal, Hamid (author)
Public Health England, Public Health Laboratory Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
Brunelli, Tamara (author)
Clinical Chemistry and Microbiology Laboratory, Santo Stefano Hospital, Prato, Italy
Casprini, Patrizia (author)
Clinical Chemistry and Microbiology Laboratory, Santo Stefano Hospital, Prato, Italy
Pitt, Rachel (author)
Sexually Transmitted Bacteria Reference Unit, Microbiological Services, Public Health England, London, United Kingdom
Ison, Cathy (author)
Sexually Transmitted Bacteria Reference Unit, Microbiological Services, Public Health England, London, United Kingdom
Savicheva, Alevtina (author)
Laboratory of Microbiology, D.O. Ott Research Institute of Obstetrics and Gynecology, St. Petersburg, Russia
Shipitsyna, Elena (author)
Laboratory of Microbiology, D.O. Ott Research Institute of Obstetrics and Gynecology, St. Petersburg, Russia; WHO Collaborating Centre for Gonorrhoea and other STIs, Faculty of Medicine and Health, Örebro University Hospital, Örebro, Sweden
Hadad, Ronza, 1984- (author)
Örebro universitet,Institutionen för naturvetenskap och teknik,WHO Collaborating Centre for Gonorrhoea and other STIs, Örebro University Hospital, Örebro, Sweden
Kari, Laszlo (author)
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton Montana, USA
Burton, Matthew J (author)
Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom
Mabey, David (author)
Centre for Infectious Diseases and Microbiology, Sydney, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, Westmead Clinical School, University of Sydney, Sydney, Australia
Solomon, Anthony W (author)
Centre for Infectious Diseases and Microbiology, Sydney, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, Westmead Clinical School, University of Sydney, Sydney, Australia
Lewis, David (author)
Centre for HIV and Sexually Transmitted Infections, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa; Centre for Infectious Diseases and Microbiology, Sydney, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, Westmead Clinical School, University of Sydney, Sydney, Australia
Marsh, Peter (author)
Public Health England, Public Health Laboratory Southampton, Southampton General Hospital, Southampton, United Kingdom
Unemo, Magnus, 1970- (author)
Örebro University, School of Medical Sciences; WHO Collaborating Centre for Gonorrhoea and other STIs, Örebro University Hospital, Örebro, Sweden
Clarke, Ian N (author)
Molecular Microbiology Group, University Medical School, Southampton General Hospital, Southampton, United Kingdom
Parkhill, Julian (author)
Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Thomson, Nicholas R. (author)
Pathogen Genomics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom; Department of Pathogen Molecular Biology, The London School of Hygiene and Tropical Medicine, London, United Kingdom
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 (creator_code:org_t)
2017-06-06
2017
English.
In: Genome Research. - : Cold Spring Harbor Laboratory Press. - 1088-9051 .- 1549-5469. ; 27:7, s. 1220-1229
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Chlamydia trachomatis is the world's most prevalent bacterial sexually transmitted infection and leading infectious cause of blindness, yet it is one of the least understood human pathogens, in part due to the difficulties of in vitro culturing and the lack of available tools for genetic manipulation. Genome sequencing has reinvigorated this field, shedding light on the contemporary history of this pathogen. Here, we analyze 563 full genomes, 455 of which are novel, to show that the history of the species comprises two phases, and conclude that the currently circulating lineages are the result of evolution in different genomic ecotypes. Temporal analysis indicates these lineages have recently expanded in the space of thousands of years, rather than the millions of years as previously thought, a finding that dramatically changes our understanding of this pathogen's history. Finally, at a time when almost every pathogen is becoming increasingly resistant to antimicrobials, we show that there is no evidence of circulating genomic resistance in C. trachomatis.

Subject headings

NATURVETENSKAP  -- Biologi -- Evolutionsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Evolutionary Biology (hsv//eng)

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