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Sökning: onr:"swepub:oai:DiVA.org:umu-184203" > Perspectives for sy...

Perspectives for systems biology in the management of tuberculosis

Kontsevaya, Irina (författare)
Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
Lange, Christoph (författare)
Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
Comella-Del-Barrio, Patricia (författare)
Research Institute Germans Trias i Pujol, CIBER Respiratory Diseases, Universitat Autònoma de Barcelona, Badalona, Spain
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Coarfa, Cristian (författare)
Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States; Molecular and Cellular Biology, Center for Precision Environmental health, Baylor College of Medicine, TX, Houston, United States
DiNardo, Andrew R. (författare)
Global Tuberculosis Program, Texas Children's Hospital, Dept of Pediatrics, Baylor College of Medicine, TX, Houston, United States
Gillespie, Stephen H. (författare)
School of Medicine, University of St Andrew, St Andrews, United Kingdom
Hauptmann, Matthias (författare)
Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany
Leschczyk, Christoph (författare)
Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany
Mandalakas, Anna M. (författare)
Global Tuberculosis Program, Texas Children's Hospital, Dept of Pediatrics, Baylor College of Medicine, TX, Houston, United States
Martinecz, Antal (författare)
Dept of Biology, Pennsylvania State University, University Park, United States; Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, United States; Dept of Pharmacy, Faculty of Health Sciences, UiT, Arctic University of Norway, Tromsø, Norway
Merker, Matthias (författare)
Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany
Niemann, Stefan (författare)
Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany
Reimann, Maja (författare)
Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
Rzhepishevska, Olena I (författare)
Umeå universitet,Kemiska institutionen,Institutionen för klinisk mikrobiologi
Schaible, Ulrich E. (författare)
Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany
Scheu, Katrin M. (författare)
Research Center Borstel, Borstel, Germany
Schurr, Erwin (författare)
Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Canada
Abel Zur Wiesch, Pia (författare)
Dept of Biology, Pennsylvania State University, University Park, United States; Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, United States
Heyckendorf, Jan (författare)
Research Center Borstel, Borstel, Germany; German Center for Infection Research, Borstel, Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany
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 (creator_code:org_t)
2021-05-25
2021
Engelska.
Ingår i: European Respiratory Review. - : European Respiratory Society (ERS). - 0905-9180 .- 1600-0617. ; 30:160
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://err.ersjourn...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • Standardised management of tuberculosis may soon be replaced by individualised, precision medicine-guided therapies informed with knowledge provided by the field of systems biology. Systems biology is a rapidly expanding field of computational and mathematical analysis and modelling of complex biological systems that can provide insights into mechanisms underlying tuberculosis, identify novel biomarkers, and help to optimise prevention, diagnosis and treatment of disease. These advances are critically important in the context of the evolving epidemic of drug-resistant tuberculosis. Here, we review the available evidence on the role of systems biology approaches - human and mycobacterial genomics and transcriptomics, proteomics, lipidomics/metabolomics, immunophenotyping, systems pharmacology and gut microbiomes - in the management of tuberculosis including prediction of risk for disease progression, severity of mycobacterial virulence and drug resistance, adverse events, comorbidities, response to therapy and treatment outcomes. Application of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach demonstrated that at present most of the studies provide "very low" certainty of evidence for answering clinically relevant questions. Further studies in large prospective cohorts of patients, including randomised clinical trials, are necessary to assess the applicability of the findings in tuberculosis prevention and more efficient clinical management of patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

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