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Circulating levels of testosterone, sex hormone binding globulin and colorectal cancer risk: Observational and mendelian randomization analyses

Dimou, Niki (författare)
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
Mori, Nagisa (författare)
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
Harlid, Sophia, 1978- (författare)
Umeå universitet,Onkologi
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Harbs, Justin (författare)
Umeå universitet,Onkologi
Martin, Richard M. (författare)
MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, United Kingdom; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, United Kingdom
Smith-Byrne, Karl (författare)
Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France
Papadimitriou, Nikos (författare)
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
Timothy Bishop, D. (författare)
Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom
Casey, Graham (författare)
Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
Colorado-Yohar, Sandra M. (författare)
Department of Epidemiology, Murcia Regional Health Council, IMIBArrixaca, Murcia, Spain; CIBER Epidemiología y Salud Publica (CIBERESP), Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
Cotterchio, Michelle (författare)
Ontario Health (Cancer Care Ontario), ON, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, ON, Toronto, Canada
Cross, Amanda J. (författare)
Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom
Le Marchand, Loic (författare)
University of Hawaii Cancer Center, HI, Honolulu, United States
Lin, Yi (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Offit, Kenneth (författare)
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, New York, United States; Department of Medicine, Weill Cornell Medical College, NY, New York, United States
Charlotte Onland-Moret, N. (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Potter, John D. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States; Centre for Public Health Research, Massey University, Wellington, New Zealand
Rohan, Thomas E. (författare)
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
Weiderpass, Elisabete (författare)
Office of the Director, International Agency for Research on Cancer, Lyon, France
Gunter, Marc J. (författare)
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
Murphy, Neil (författare)
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
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 (creator_code:org_t)
AACR Publications, 2021
2021
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : AACR Publications. - 1055-9965 .- 1538-7755. ; 30:7, s. 1336-1348
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Epidemiologic studies evaluating associations between sex steroid hormones and colorectal cancer risk have yielded inconsistent results. To elucidate the role of circulating levels of testosterone, and sex hormone-binding globulin (SHBG) in colorectal cancer risk, we conducted observational and Mendelian randomization (MR) analyses.Methods: The observational analyses included 333,530 participants enrolled in the UK Biobank with testosterone and SHBG measured. HRs and 95% confidence intervals (CI) were estimated using multivariable Cox proportional hazards models. For MR analyses, genetic variants robustly associated with hormone levels were identified and their association with colorectal cancer (42,866 cases/42,752 controls) was examined using two-sample MR.Results: In the observational analysis, there was little evidence that circulating levels of total testosterone were associated with colorectal cancer risk; the MR analyses showed a greater risk for women (OR per 1-SD = 1.09; 95% CI, 1.01-1.17), although pleiotropy may have biased this result. Higher SHBG concentrations were associated with greater colorectal cancer risk for women (HR per 1-SD = 1.16; 95% CI, 1.05-1.29), but was unsupported by the MR analysis. There was little evidence of associations between free testosterone and colorectal cancer in observational andMRanalyses.Conclusions: Circulating concentrations of sex hormones are unlikely to be causally associated with colorectal cancer. Additional experimental studies are required to better understand the possible role of androgens in colorectal cancer development.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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