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Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Schijven, Dick (author)
Postema, Merel C. (author)
Fukunaga, Masaki (author)
show more...
Matsumoto, Junya (author)
Miura, Kenichiro (author)
de Zwarte, Sonja M. C. (author)
van Haren, Neeltje E. M. (author)
Cahn, Wiepke (author)
Hulshoff Pol, Hilleke E. (author)
Kahn, René S. (author)
Ayesa-Arriola, Rosa (author)
Ortiz-García de la Foz, Víctor (author)
Tordesillas-Gutierrez, Diana (author)
Vázquez-Bourgon, Javier (author)
Crespo-Facorro, Benedicto (author)
Alnæs, Dag (author)
Dahl, Andreas (author)
Westlye, Lars T. (author)
Agartz, Ingrid (author)
Andreassen, Ole A. (author)
Jönsson, Erik G. (author)
Karolinska Institutet
Kochunov, Peter (author)
Bruggemann, Jason M. (author)
Catts, Stanley V. (author)
Michie, Patricia T. (author)
Mowry, Bryan J. (author)
Quidé, Yann (author)
Rasser, Paul E. (author)
Schall, Ulrich (author)
Scott, Rodney J. (author)
Carr, Vaughan J. (author)
Green, Melissa J. (author)
Henskens, Frans A. (author)
Loughland, Carmel M. (author)
Pantelis, Christos (author)
Weickert, Cynthia Shannon (author)
Weickert, Thomas W. (author)
de Haan, Lieuwe (author)
Brosch, Katharina (author)
Pfarr, Julia-Katharina (author)
Ringwald, Kai G. (author)
Stein, Frederike (author)
Jansen, Andreas (author)
Kircher, Tilo T. J. (author)
Nenadić, Igor (author)
Krämer, Bernd (author)
Gruber, Oliver (author)
Satterthwaite, Theodore D. (author)
Bustillo, Juan (author)
Mathalon, Daniel H. (author)
Preda, Adrian (author)
Calhoun, Vince D. (author)
Ford, Judith M. (author)
Potkin, Steven G. (author)
Chen, Jingxu (author)
Tan, Yunlong (author)
Wang, Zhiren (author)
Xiang, Hong (author)
Fan, Fengmei (author)
Bernardoni, Fabio (author)
Ehrlich, Stefan (author)
Fuentes-Claramonte, Paola (author)
Garcia-Leon, Maria Angeles (author)
Guerrero-Pedraza, Amalia (author)
Salvador, Raymond (author)
Sarró, Salvador (author)
Pomarol-Clotet, Edith (author)
Ciullo, Valentina (author)
Piras, Fabrizio (author)
Vecchio, Daniela (author)
Banaj, Nerisa (author)
Spalletta, Gianfranco (author)
Michielse, Stijn (author)
van Amelsvoort, Therese (author)
Dickie, Erin W. (author)
Voineskos, Aristotle N. (author)
Sim, Kang (author)
Ciufolini, Simone (author)
Dazzan, Paola (author)
Murray, Robin M. (author)
Kim, Woo-Sung (author)
Chung, Young-Chul (author)
Andreou, Christina (author)
Schmidt, André (author)
Borgwardt, Stefan (author)
McIntosh, Andrew M. (author)
Whalley, Heather C. (author)
Lawrie, Stephen M. (author)
du Plessis, Stefan (author)
Luckhoff, Hilmar K. (author)
Scheffler, Freda (author)
Emsley, Robin (author)
Grotegerd, Dominik (author)
Lencer, Rebekka (author)
Dannlowski, Udo (author)
Edmond, Jesse T. (author)
Rootes-Murdy, Kelly (author)
Stephen, Julia M. (author)
Mayer, Andrew R. (author)
Antonucci, Linda A. (author)
Fazio, Leonardo (author)
Pergola, Giulio (author)
Bertolino, Alessandro (author)
Díaz-Caneja, Covadonga M. (author)
Janssen, Joost (author)
Lois, Noemi G. (author)
Arango, Celso (author)
Tomyshev, Alexander S. (author)
Lebedeva, Irina (author)
Cervenka, Simon (author)
Uppsala universitet,Psykiatri,Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm 113 64, Sweden
Sellgren, Carl M. (author)
Georgiadis, Foivos (author)
Kirschner, Matthias (author)
Kaiser, Stefan (author)
Hajek, Tomas (author)
Skoch, Antonin (author)
Spaniel, Filip (author)
Kim, Minah (author)
Kwak, Yoo Bin (author)
Oh, Sanghoon (author)
Kwon, Jun Soo (author)
James, Anthony (author)
Bakker, Geor (author)
Knöchel, Christian (author)
Stäblein, Michael (author)
Oertel, Viola (author)
Uhlmann, Anne (author)
Howells, Fleur M. (author)
Stein, Dan J. (author)
Temmingh, Henk S. (author)
Diaz-Zuluaga, Ana M. (author)
Pineda-Zapata, Julian A. (author)
López-Jaramillo, Carlos (author)
Homan, Stephanie (author)
Ji, Ellen (author)
Surbeck, Werner (author)
Homan, Philipp (author)
Fisher, Simon E. (author)
Franke, Barbara (author)
Glahn, David C. (author)
Gur, Ruben C. (author)
Hashimoto, Ryota (author)
Jahanshad, Neda (author)
Lueders, Eileen (author)
Uppsala universitet,Reproduktiv hälsa,School of Psychology, University of Auckland, Auckland 1010, New Zealand; Laboratory of Neuro Imaging, School of Medicine, University of Southern California, Los Angeles, CA 90033
Medland, Sarah E. (author)
Thompson, Paul M. (author)
Turner, Jessica A. (author)
van Erp, Theo G. M. (author)
Francks, Clyde (author)
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 (creator_code:org_t)
2023-03-28
2023
English.
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences (PNAS). - 0027-8424 .- 1091-6490. ; 120:14
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Schizophrenia
asymmetry
brain imaging
cortical
subcortical

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Schijven, Dick
Postema, Merel C ...
Fukunaga, Masaki
Matsumoto, Junya
Miura, Kenichiro
de Zwarte, Sonja ...
show more...
van Haren, Neelt ...
Cahn, Wiepke
Hulshoff Pol, Hi ...
Kahn, René S.
Ayesa-Arriola, R ...
Ortiz-García de ...
Tordesillas-Guti ...
Vázquez-Bourgon, ...
Crespo-Facorro, ...
Alnæs, Dag
Dahl, Andreas
Westlye, Lars T.
Agartz, Ingrid
Andreassen, Ole ...
Jönsson, Erik G.
Kochunov, Peter
Bruggemann, Jaso ...
Catts, Stanley V ...
Michie, Patricia ...
Mowry, Bryan J.
Quidé, Yann
Rasser, Paul E.
Schall, Ulrich
Scott, Rodney J.
Carr, Vaughan J.
Green, Melissa J ...
Henskens, Frans ...
Loughland, Carme ...
Pantelis, Christ ...
Weickert, Cynthi ...
Weickert, Thomas ...
de Haan, Lieuwe
Brosch, Katharin ...
Pfarr, Julia-Kat ...
Ringwald, Kai G.
Stein, Frederike
Jansen, Andreas
Kircher, Tilo T. ...
Nenadić, Igor
Krämer, Bernd
Gruber, Oliver
Satterthwaite, T ...
Bustillo, Juan
Mathalon, Daniel ...
Preda, Adrian
Calhoun, Vince D ...
Ford, Judith M.
Potkin, Steven G ...
Chen, Jingxu
Tan, Yunlong
Wang, Zhiren
Xiang, Hong
Fan, Fengmei
Bernardoni, Fabi ...
Ehrlich, Stefan
Fuentes-Claramon ...
Garcia-Leon, Mar ...
Guerrero-Pedraza ...
Salvador, Raymon ...
Sarró, Salvador
Pomarol-Clotet, ...
Ciullo, Valentin ...
Piras, Fabrizio
Vecchio, Daniela
Banaj, Nerisa
Spalletta, Gianf ...
Michielse, Stijn
van Amelsvoort, ...
Dickie, Erin W.
Voineskos, Arist ...
Sim, Kang
Ciufolini, Simon ...
Dazzan, Paola
Murray, Robin M.
Kim, Woo-Sung
Chung, Young-Chu ...
Andreou, Christi ...
Schmidt, André
Borgwardt, Stefa ...
McIntosh, Andrew ...
Whalley, Heather ...
Lawrie, Stephen ...
du Plessis, Stef ...
Luckhoff, Hilmar ...
Scheffler, Freda
Emsley, Robin
Grotegerd, Domin ...
Lencer, Rebekka
Dannlowski, Udo
Edmond, Jesse T.
Rootes-Murdy, Ke ...
Stephen, Julia M ...
Mayer, Andrew R.
Antonucci, Linda ...
Fazio, Leonardo
Pergola, Giulio
Bertolino, Aless ...
Díaz-Caneja, Cov ...
Janssen, Joost
Lois, Noemi G.
Arango, Celso
Tomyshev, Alexan ...
Lebedeva, Irina
Cervenka, Simon
Sellgren, Carl M ...
Georgiadis, Foiv ...
Kirschner, Matth ...
Kaiser, Stefan
Hajek, Tomas
Skoch, Antonin
Spaniel, Filip
Kim, Minah
Kwak, Yoo Bin
Oh, Sanghoon
Kwon, Jun Soo
James, Anthony
Bakker, Geor
Knöchel, Christi ...
Stäblein, Michae ...
Oertel, Viola
Uhlmann, Anne
Howells, Fleur M ...
Stein, Dan J.
Temmingh, Henk S ...
Diaz-Zuluaga, An ...
Pineda-Zapata, J ...
López-Jaramillo, ...
Homan, Stephanie
Ji, Ellen
Surbeck, Werner
Homan, Philipp
Fisher, Simon E.
Franke, Barbara
Glahn, David C.
Gur, Ruben C.
Hashimoto, Ryota
Jahanshad, Neda
Lueders, Eileen
Medland, Sarah E ...
Thompson, Paul M ...
Turner, Jessica ...
van Erp, Theo G. ...
Francks, Clyde
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Psychiatry
Articles in the publication
Proceedings of t ...
By the university
Uppsala University
Karolinska Institutet

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