Search: WFRF:(Cronin Simon) >
RANK rewires energy...
RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer
-
- Rao, Shuan (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
- Sigl, Verena (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
- Wimmer, Reiner Alois (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
show more...
-
- Novatchkova, Maria (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
- Jais, Alexander (author)
- Med Univ Vienna, Dept Lab Med, A-1090 Vienna, Austria.;Max Planck Inst Metab Res, Dept Neuronal Control Metab, D-50931 Cologne, Germany.
-
- Wagner, Gabriel (author)
- Med Univ Vienna, Dept Lab Med, A-1090 Vienna, Austria.
-
- Handschuh, Stephan (author)
- Univ Vet Med, VetCore Facil Res, A-1220 Vienna, Austria.
-
- Uribesalgo, Iris (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
- Hagelkruys, Astrid (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
- Kozieradzki, Ivona (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
- Tortola, Luigi (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
- Nitsch, Roberto (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
- Cronin, Shane J. (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
- Orthofer, Michael (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
- Branstetter, Daniel (author)
- Amgen Inc, Dept Pathol, Seattle, WA 98119 USA.
-
- Canon, Jude (author)
- Amgen Inc, Dept Oncol Res, Seattle, WA 98119 USA.
-
- Rossi, John (author)
- Amgen Inc, Dept Mol Sci, Seattle, WA 98119 USA.
-
- D'Arcangelo, Manolo (author)
- Univ Colorado, Ctr Canc, Aurora, CO 80045 USA.
-
- Botling, Johan (author)
- Uppsala universitet,Klinisk och experimentell patologi,Johan Botling
-
- Micke, Patrick (author)
- Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
-
- La Fleur, Linnea (author)
- Uppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Johan Botling
-
- Edlund, Karolina (author)
- Leibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany.
-
- Bergqvist, Michael (author)
- Gavle Cent Hosp, Dept Oncol, S-80187 Gavle, Sweden.
-
- Ekman, Simon (author)
- Karolinska Institutet
-
- Lendl, Thomas (author)
- Gregor Mendel Inst Mol Plant Biol GMI, A-1030 Vienna, Austria.
-
- Popper, Helmut (author)
- Med Univ Graz, Inst Pathol, Res Unit Mol Lung & Pleura Pathol, A-8036 Graz, Austria.
-
- Takayanagi, Hiroshi (author)
- Univ Tokyo, Dept Immunol, Tokyo 1088639, Japan.
-
- Kenner, Lukas (author)
- Med Univ Vienna, Dept Clin Pathol, A-1090 Vienna, Austria.;Ludwig Boltzmann Inst Canc Res, A-1090 Vienna, Austria.;Univ Vet Med Vienna, Unit Pathol Lab Anim, A-1220 Vienna, Austria.
-
- Hirsch, Fred R. (author)
- Univ Colorado, Ctr Canc, Aurora, CO 80045 USA.
-
- Dougall, William (author)
- Amgen Inc, Dept Oncol Res, Seattle, WA 98119 USA.;QIMR, Berghofer Med Res Inst, Dept Immunol Canc & Infect, Brisbane, Qld 4006, Australia.
-
- Penninger, Josef (author)
- Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
-
show less...
-
Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria Med Univ Vienna, Dept Lab Med, A-1090 Vienna, Austria.;Max Planck Inst Metab Res, Dept Neuronal Control Metab, D-50931 Cologne, Germany. (creator_code:org_t)
- 2017-11-08
- 2017
- English.
-
In: Genes & Development. - : Cold Spring Harbor Laboratory. - 0890-9369 .- 1549-5477. ; 31:20, s. 2099-2112
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
http://genesdev.cshl...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Lung cancer is the leading cause of cancer deaths. Besides smoking, epidemiological studies have linked female sex hormones to lung cancer in women; however, the underlying mechanisms remain unclear. Here we report that the receptor activator of nuclear factor-kB (RANK), the key regulator of osteoclastogenesis, is frequently expressed in primary lung tumors, an active RANK pathway correlates with decreased survival, and pharmacologic RANK inhibition reduces tumor growth in patient-derived lung cancer xenografts. Clonal genetic inactivation of KRas(G12D) in mouse lung epithelial cells markedly impairs the progression of KRas(G12D)-driven lung cancer, resulting in a significant survival advantage. Mechanistically, RANK rewires energy homeostasis in human and murine lung cancer cells and promotes expansion of lung cancer stem-like cells, which is blocked by inhibiting mitochondrial respiration. Our data also indicate survival differences in KRas(G12D)-driven lung cancer between male and female mice, and we show that female sex hormones can promote lung cancer progression via the RANK pathway. These data uncover a direct role for RANK in lung cancer and may explain why female sex hormones accelerate lung cancer development. Inhibition of RANK using the approved drug denosumab may be a therapeutic drug candidate for primary lung cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- RANK
- energy homeostasis
- lung cancer
- lung cancer stem-like cells
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Rao, Shuan
-
Sigl, Verena
-
Wimmer, Reiner A ...
-
Novatchkova, Mar ...
-
Jais, Alexander
-
Wagner, Gabriel
-
show more...
-
Handschuh, Steph ...
-
Uribesalgo, Iris
-
Hagelkruys, Astr ...
-
Kozieradzki, Ivo ...
-
Tortola, Luigi
-
Nitsch, Roberto
-
Cronin, Shane J.
-
Orthofer, Michae ...
-
Branstetter, Dan ...
-
Canon, Jude
-
Rossi, John
-
D'Arcangelo, Man ...
-
Botling, Johan
-
Micke, Patrick
-
La Fleur, Linnea
-
Edlund, Karolina
-
Bergqvist, Micha ...
-
Ekman, Simon
-
Lendl, Thomas
-
Popper, Helmut
-
Takayanagi, Hiro ...
-
Kenner, Lukas
-
Hirsch, Fred R.
-
Dougall, William
-
Penninger, Josef
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Clinical Laborat ...
- Articles in the publication
-
Genes & Developm ...
- By the university
-
Uppsala University
-
Karolinska Institutet