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Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
- Dadaev, T (author)
- Saunders, EJ (author)
- Newcombe, PJ (author)
- show more...
- Anokian, E (author)
- Leongamornlert, DA (author)
- Brook, MN (author)
- Cieza-Borrella, C (author)
- Mijuskovic, M (author)
- Wakerell, S (author)
- Al Olama, AA (author)
- Schumacher, FR (author)
- Berndt, SI (author)
- Benlloch, S (author)
- Ahmed, M (author)
- Goh, C (author)
- Sheng, X (author)
- Zhang, Z (author)
- Muir, K (author)
- Govindasami, K (author)
- Lophatananon, A (author)
- Stevens, VL (author)
- Gapstur, SM (author)
- Carter, BD (author)
- Tangen, CM (author)
- Goodman, P (author)
- Thompson, IM (author)
- Batra, J (author)
- Chambers, S (author)
- Moya, L (author)
- Clements, J (author)
- Horvath, L (author)
- Tilley, W (author)
- Risbridger, G (author)
- Pharoah, P (author)
- Pashayan, N (author)
- Schleutker, J (author)
- Tammela, TLJ (author)
- Sipeky, C (author)
- Auvinen, A (author)
- Albanes, D (author)
- Weinstein, S (author)
- West, C (author)
- Dunning, AM (author)
- Burnet, N (author)
- Mucci, L (author)
- Giovannucci, E (author)
- Andriole, G (author)
- Cussenot, O (author)
- Cancel-Tassin, G (author)
- Koutros, S (author)
- Freeman, LEB (author)
- Sorensen, KD (author)
- Orntoft, TF (author)
- Borre, M (author)
- Maehle, L (author)
- Grindedal, EM (author)
- Neal, DE (author)
- Donovan, JL (author)
- Hamdy, FC (author)
- Martin, RM (author)
- Travis, RC (author)
- Key, TJ (author)
- Hamilton, RJ (author)
- Fleshner, NE (author)
- Finelli, A (author)
- Ingles, SA (author)
- Stern, MC (author)
- Rosenstein, B (author)
- Kerns, S (author)
- Ostrer, H (author)
- Lu, YJ (author)
- Zhang, HW (author)
- Feng, N (author)
- Mao, X (author)
- Guo, X (author)
- Wang, GM (author)
- Sun, Z (author)
- Giles, GG (author)
- Southey, MC (author)
- MacInnis, RJ (author)
- FitzGerald, LM (author)
- Kibel, AS (author)
- Drake, BF (author)
- Vega, A (author)
- Gomez-Caamano, A (author)
- Fachal, L (author)
- Kogevinas, M (author)
- Llorca, J (author)
- Castano-Vinyals, G (author)
- Penney, KL (author)
- Stampfer, M (author)
- Park, JY (author)
- Sellers, TA (author)
- Lin, HY (author)
- Stanford, JL (author)
- Cybulski, C (author)
- Wokolorczyk, D (author)
- Lubinski, J (author)
- Ostrander, EA (author)
- Geybels, MS (author)
- Nordestgaard, BG (author)
- Nielsen, SF (author)
- Weisher, M (author)
- Bisbjerg, R (author)
- Roder, MA (author)
- Iversen, P (author)
- Brenner, H (author)
- Cuk, K (author)
- Holleczek, B (author)
- Maier, C (author)
- Luedeke, M (author)
- Schnoeller, T (author)
- Kim, J (author)
- Logothetis, CJ (author)
- John, EM (author)
- Teixeira, MR (author)
- Paulo, P (author)
- Cardoso, M (author)
- Neuhausen, SL (author)
- Steele, L (author)
- Ding, YC (author)
- De Ruyck, K (author)
- De Meerleer, G (author)
- Ost, P (author)
- Razack, A (author)
- Lim, J (author)
- Teo, SH (author)
- Lin, DW (author)
- Newcomb, LF (author)
- Lessel, D (author)
- Gamulin, M (author)
- Kulis, T (author)
- Kaneva, R (author)
- Usmani, N (author)
- Slavov, C (author)
- Mitev, V (author)
- Parliament, M (author)
- Singhal, S (author)
- Claessens, F (author)
- Joniau, S (author)
- Van den Broeck, T (author)
- Larkin, S (author)
- Townsend, PA (author)
- Aukim-Hastie, C (author)
- Gago-Dominguez, M (author)
- Castelao, JE (author)
- Martinez, ME (author)
- Roobol, MJ (author)
- Jenster, G (author)
- van Schaik, RHN (author)
- Menegaux, F (author)
- Truong, T (author)
- Koudou, YA (author)
- Xu, JF (author)
- Khaw, KT (author)
- Cannon-Albright, L (author)
- Pandha, H (author)
- Michael, A (author)
- Kierzek, A (author)
- Thibodeau, SN (author)
- McDonnell, SK (author)
- Schaid, DJ (author)
- Lindstrom, S (author)
- Turman, C (author)
- Ma, J (author)
- Hunter, DJ (author)
- Riboli, E (author)
- Siddiq, A (author)
- Canzian, F (author)
- Kolonel, LN (author)
- Le Marchand, L (author)
- Hoover, RN (author)
- Machiela, MJ (author)
- Kraft, P (author)
- Freedman, M (author)
- Chanock, S (author)
- Henderson, BE (author)
- Easton, DF (author)
- Haiman, CA (author)
- Eeles, RA (author)
- Conti, DV (author)
- Kote-Jarai, Z (author)
- show less...
- (creator_code:org_t)
- 2018-06-11
- 2018
- English.
- In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 2256-
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Dadaev, T
- Saunders, EJ
- Newcombe, PJ
- Anokian, E
- Leongamornlert, ...
- Brook, MN
- show more...
- Cieza-Borrella, ...
- Mijuskovic, M
- Wakerell, S
- Al Olama, AA
- Schumacher, FR
- Berndt, SI
- Benlloch, S
- Ahmed, M
- Goh, C
- Sheng, X
- Zhang, Z
- Muir, K
- Govindasami, K
- Lophatananon, A
- Stevens, VL
- Gapstur, SM
- Carter, BD
- Tangen, CM
- Goodman, P
- Thompson, IM
- Batra, J
- Chambers, S
- Moya, L
- Clements, J
- Horvath, L
- Tilley, W
- Risbridger, G
- Gronberg, H
- Aly, M
- Nordstrom, T
- Pharoah, P
- Pashayan, N
- Schleutker, J
- Tammela, TLJ
- Sipeky, C
- Auvinen, A
- Albanes, D
- Weinstein, S
- Wolk, Alicja
- Hakansson, N
- West, C
- Dunning, AM
- Burnet, N
- Mucci, L
- Giovannucci, E
- Andriole, G
- Cussenot, O
- Cancel-Tassin, G
- Koutros, S
- Freeman, LEB
- Sorensen, KD
- Orntoft, TF
- Borre, M
- Maehle, L
- Grindedal, EM
- Neal, DE
- Donovan, JL
- Hamdy, FC
- Martin, RM
- Travis, RC
- Key, TJ
- Hamilton, RJ
- Fleshner, NE
- Finelli, A
- Ingles, SA
- Stern, MC
- Rosenstein, B
- Kerns, S
- Ostrer, H
- Lu, YJ
- Zhang, HW
- Feng, N
- Mao, X
- Guo, X
- Wang, GM
- Sun, Z
- Giles, GG
- Southey, MC
- MacInnis, RJ
- FitzGerald, LM
- Kibel, AS
- Drake, BF
- Vega, A
- Gomez-Caamano, A
- Fachal, L
- Szulkin, R
- Eklund, M
- Kogevinas, M
- Llorca, J
- Castano-Vinyals, ...
- Penney, KL
- Stampfer, M
- Park, JY
- Sellers, TA
- Lin, HY
- Stanford, JL
- Cybulski, C
- Wokolorczyk, D
- Lubinski, J
- Ostrander, EA
- Geybels, MS
- Nordestgaard, BG
- Nielsen, SF
- Weisher, M
- Bisbjerg, R
- Roder, MA
- Iversen, P
- Brenner, H
- Cuk, K
- Holleczek, B
- Maier, C
- Luedeke, M
- Schnoeller, T
- Kim, J
- Logothetis, CJ
- John, EM
- Teixeira, MR
- Paulo, P
- Cardoso, M
- Neuhausen, SL
- Steele, L
- Ding, YC
- De Ruyck, K
- De Meerleer, G
- Ost, P
- Razack, A
- Lim, J
- Teo, SH
- Lin, DW
- Newcomb, LF
- Lessel, D
- Gamulin, M
- Kulis, T
- Kaneva, R
- Usmani, N
- Slavov, C
- Mitev, V
- Parliament, M
- Singhal, S
- Claessens, F
- Joniau, S
- Van den Broeck, ...
- Larkin, S
- Townsend, PA
- Aukim-Hastie, C
- Gago-Dominguez, ...
- Castelao, JE
- Martinez, ME
- Roobol, MJ
- Jenster, G
- van Schaik, RHN
- Menegaux, F
- Truong, T
- Koudou, YA
- Xu, JF
- Khaw, KT
- Cannon-Albright, ...
- Pandha, H
- Michael, A
- Kierzek, A
- Thibodeau, SN
- McDonnell, SK
- Schaid, DJ
- Lindstrom, S
- Turman, C
- Ma, J
- Hunter, DJ
- Riboli, E
- Siddiq, A
- Canzian, F
- Kolonel, LN
- Le Marchand, L
- Hoover, RN
- Machiela, MJ
- Kraft, P
- Freedman, M
- Wiklund, F
- Chanock, S
- Henderson, BE
- Easton, DF
- Haiman, CA
- Eeles, RA
- Conti, DV
- Kote-Jarai, Z
- show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Urology and Neph ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
- Articles in the publication
- Nature communica ...
- By the university
- Karolinska Institutet
- Uppsala University
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