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Milk intake and incident stroke and coronary heart disease in populations of European descent : a mendelian randomization study

Vissers, L.E.T. (författare)
Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, University Utrecht, Utrecht, Netherlands
Sluijs, I. (författare)
Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, University Utrecht, Utrecht, Netherlands
Burgess, S. (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom,University of Potsdam,German Institute of Human Nutrition,German Center for Diabetes Research
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Forouhi, N.G. (författare)
MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Freisling, H. (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Imamura, F. (författare)
MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Nilsson, Torbjörn K. (författare)
Umeå University,Umeå universitet,Klinisk kemi
Renström, Frida (författare)
Umeå University,Umeå universitet,Enheten för biobanksforskning,Division of Endocrinology and Diabetes, Cantonal Hospital St. Gallen, St. Gallen, Switzerland,Kantonsspital St Gallen
Weiderpass, E. (författare)
International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
Aleksandrova, K. (författare)
Germany Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany
Dahm, C.C. (författare)
Department of Public Health, Aarhus University, Aarhus, Denmark,CIBER Epidemiology and Public Health (CIBERESP),University of Murcia
Perez-Cornago, A. (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Schulze, M.B. (författare)
German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Germany Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany
Tong, T.Y.N. (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Aune, D. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Bjørknes University College, Oslo, Norway; Department of Endocrinology Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
Bonet, C. (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain,Bellvitge University Hospital-IDIBELL
Boer, J.M.A. (författare)
National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM)
Boeing, H. (författare)
German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
Chirlaque, M.D. (författare)
Department of Epidemiology, Regional Health Council IMIB-Arrixaca, Murcia University, Murcia, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Conchi, M.I. (författare)
Navarra Public Health Institute - IdiSNA, Pamplona, Spain; Research Network on Health Services in Chronic Diseases (REDISSEC), Pamplona, Spain,Health Services Research on Chronic Patients Network (REDISSEC)
Imaz, L. (författare)
Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa Donostia-San Sebastian, Spain; Biodonostia Health Research Institute, Spain
Sánches, M. J. (författare)
German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany,University of Granada,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
Krogh, V. (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Instituto Nazionale Dei Tumori, Milano, Italy
Kyrø, C. (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark
Masala, G. (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research Prevention and Clinical Network - ISPRO, Florence, Italy
Melander, O. (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Overvad, K. (författare)
Department of Public Health, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
Panico, S. (författare)
Dipartemento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
Sánches, M.J. (författare)
CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Andalusian School of Public Health (EASP), Granada, Spain; Instituto de Investigación Biosanitaria de Granada, Granada, Spain; Universidad de Granada, Granada, Spain
Sonestedt, E. (författare)
Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
Tjønneland, A. (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark
Tzoulaki, I. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Verschuren, W.M.M. (författare)
Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, University Utrecht, Utrecht, Netherlands; National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM)
Riboli, E. (författare)
School of Public Health, Imperial College, London, United Kingdom
Wareham, N.J. (författare)
MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Danesh, J. (författare)
MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Butterworth, A.S. (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom
Van Der Schouw, Y.T. (författare)
Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, University Utrecht, Utrecht, Netherlands
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 (creator_code:org_t)
Cambridge University Press, 2022
2022
Engelska.
Ingår i: British Journal of Nutrition. - : Cambridge University Press. - 0007-1145 .- 1475-2662. ; 128:9, s. 1789-1797
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
http://dx.doi.org/10... (free)
https://urn.kb.se/re...
https://doi.org/10.1...
https://lup.lub.lu.s...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Higher milk intake has been associated with a lower stroke risk, but not with risk of coronary heart disease (CHD). Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with stroke and CHD risk through instrumental variable (IV) and gene-outcome analyses. IV analysis included 29,328 participants (4,611 stroke; 9,828 CHD) of the EPIC-CVD (8 European countries) and EPIC-NL case-cohort studies. rs4988235, a lactase persistence (LP) single nucleotide polymorphism which enables digestion of lactose in adulthood was used as genetic instrument. Intake of milk was first regressed on rs4988235 in a linear regression model. Next, associations of genetically predicted milk consumption with stroke and CHD were estimated using Prentice-weighted Cox regression. Gene-outcome analysis included 777,024 participants (50,804 cases) from MEGASTROKE (including EPIC-CVD), UK Biobank and EPIC-NL for stroke, and 483,966 participants (61,612 cases) from CARDIoGRAM, UK Biobank and EPIC-CVD and EPIC-NL for CHD. In IV analyses, each additional LP allele was associated with a higher intake of milk in EPIC-CVD (β=13.7 g/day; 95%CI: 8.4-19.1) and EPIC-NL (36.8 g/day; 20.0-53.5). Genetically predicted milk intake was not associated with stroke (HR per 25 g/day 1.05; 95%CI: 0.94-1.16) or CHD (1.02; 0.96-1.08). In gene-outcome analyses, there was no association of rs4988235 with risk of stroke (odds ratios 1.02; 0.99-1.05) or CHD (0.99; 0.95-1.03). Current Mendelian Randomization analysis does not provide evidence for a causal inverse relationship between milk consumption and stroke or CHD risk.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

CHD
dairy
Mendelian Randomization
Milk
stroke
CHD
dairy
Mendelian Randomization
Milk
stroke

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