Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy

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Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy

Opel, Nils (author): Univ Munster, Germany

Narr, Katherine L. (author): Univ Calif Los Angeles, CA 90024 USA; Univ Calif Los Angeles, CA 90024 USA; Univ Calif Los Angeles, CA 90024 USA

Abbott, Christopher (author): Univ New Mexico, NM 87131 USA

Argyelan, Miklos (author): Feintein Inst Med Res, NY USA; Zucker Hillside Hosp, NY USA

Espinoza, Randall (author): Univ Calif Los Angeles, CA 90024 USA

Emsell, Louise (author): Katholieke Univ Leuven, Belgium

Bouckaert, Filip (author): Katholieke Univ Leuven, Belgium

Sienaert, Pascal (author): Katholieke Univ Leuven, Belgium

Vandenbulcke, Mathieu (author): Katholieke Univ Leuven, Belgium

Nordanskog, Pia (author): Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping

Repple, Jonathan (author): Univ Munster, Germany

Kavakbasi, Erhan (author): Univ Munster, Germany

Jorgensen, Martin B. (author): Rigshosp, Denmark

Paulson, Olaf B. (author): Rigshosp, Denmark; Univ Copenhagen, Denmark

Hanson, Lars G. (author): Copenhagen Univ Hosp Hvidovre, Denmark; Tech Univ Denmark, Denmark

Dols, Annemieke (author): GGZ Geest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands

van Exel, Eric (author): GGZ Geest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands

Oudega, Mardien L. (author): GGZ Geest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands

Takamiya, Akihiro (author): Keio Univ, Japan

Kishimoto, Taishiro (author): Keio Univ, Japan

Ousdal, Olga Therese (author): Haukeland Hosp, Norway

Haavik, Jan (author): Univ Bergen, Norway; Haukeland Hosp, Norway

Hammar, Asa (author): Haukeland Hosp, Norway; Univ Bergen, Norway

Oedegaard, Ketil Joachim (author): Haukeland Hosp, Norway; Univ Bergen, Norway

Kessler, Ute (author): Haukeland Hosp, Norway; Univ Bergen, Norway

Bartsch, Hauke (author): Univ Calif San Diego, CA 92093 USA; Haukeland Hosp, Norway

Dale, Anders M. (author): Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA USA

Baune, Bernhard T. (author): Univ Munster, Germany; Univ Melbourne, Australia; Univ Melbourne, Australia

Dannlowski, Udo (author): Univ Munster, Germany

Oltedal, Leif (author): Univ Bergen, Norway; Haukeland Hosp, Norway

Redlich, Ronny (author): Univ Munster, Germany; Univ Halle, Germany

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2021-07-01
2021
English.
In: Journal of Psychiatry & Neuroscience. - : CMA-Canadian Medical Association. - 1180-4882 .- 1488-2434. ; 46:4, s. E418-E426

Related links:: https://liu.diva-por... (primary) (Raw object); show more...; https://www.jpn.ca/c...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Obesity is a frequent somatic comorbidity of major depression, and it has been associated with worse clinical outcomes and brain structural abnormalities. Converging evidence suggests that electroconvulsive therapy (ECT) induces both clinical improvements and increased subcortical grey matter volume in patients with depression. However, it remains unknown whether increased body weight modulates the clinical response and structural neuroplasticity that occur with ECT. Methods: To address this question, we conducted a longitudinal investigation of structural MRI data from the Global ECT-MRI Research Collaboration (GEMRIC) in 223 patients who were experiencing a major depressive episode (10 scanning sites). Structural MRI data were acquired before and after ECT, and we assessed change in subcortical grey matter volume using FreeSurfer and Quarc. Results: Higher body mass index (BMI) was associated with a significantly lower increase in subcortical grey matter volume following ECT. We observed significant negative associations between BMI and change in subcortical grey matter volume, with pronounced effects in the thalamus and putamen, where obese participants showed increases in grey matter volume that were 43.3% and 49.6%, respectively, of the increases found in participants with normal weight. As well, BMI significantly moderated the association between subcortical grey matter volume change and clinical response to ECT. We observed no significant association between BMI and clinical response to ECT. Limitations: Because only baseline BMI values were available, we were unable to study BMI changes during ECT and their potential association with clinical and grey matter volume change. Conclusion: Future studies should take into account the relevance of body weight as a modulator of structural neuroplasticity during ECT treatment and aim to further explore the functional relevance of this novel finding.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: Journal of Psych ...

By the university: Linköping University

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Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy

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