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Testing mutual excl...
Testing mutual exclusivity of ETS rearranged prostate cancer
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- Svensson, Maria A. (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- LaFargue, Christopher J. (author)
- Dept Pathol & Lab Med, Weill Cornell Med Coll, New York NY, USA
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MacDonald, Theresa Y. (author)
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- Pflueger, Dorothee (author)
- Dept Pathol & Lab Med, Weill Cornell Med Coll, New York NY, USA
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- Kitabayashi, Naoki (author)
- Dept Pathol & Lab Med, Weill Cornell Med Coll, New York NY, USA
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- Santa-Cruz, Ashley M. (author)
- Ventana, Tucson AZ, USA
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- Garsha, Karl E. (author)
- Ventana, Tucson AZ, USA
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- Sathyanarayana, Ubaradka G. (author)
- Ventana, Tucson AZ, USA
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- Riley, Janice P. (author)
- Ventana, Tucson AZ, USA
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Yun, Chol S. (author)
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- Nagy, Dea (author)
- Ventana, Tucson AZ, USA
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- Kosmeder, Jerry W. (author)
- Ventana, Tucson AZ, USA
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- Pestano, Gary A. (author)
- Ventana, Tucson AZ, USA
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- Tewari, Ashutosh K. (author)
- Dept Urol, Weill Cornell Med Coll, New York NY, USA
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- Demichelis, Francesca (author)
- Dept Pathol & Lab Med, Weill Cornell Med Coll, New York NY, USA; Inst Computat Biomed, Weill Cornell Med Coll, New York, USA
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- Rubin, Mark A. (author)
- Dept Pathol & Lab Med, Weill Cornell Med Coll, New York NY, USA
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: Laboratory Investigation. - : Elsevier BV. - 0023-6837 .- 1530-0307. ; 91:3, s. 404-412
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Abstract
Subject headings
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- Prostate cancer is a clinically heterogeneous and multifocal disease. More than 80% of patients with prostate cancer harbor multiple geographically discrete cancer foci at the time of diagnosis. Emerging data suggest that these foci are molecularly distinct consistent with the hypothesis that they arise as independent clones. One of the strongest arguments is the heterogeneity observed in the status of E26 transformation specific (ETS) rearrangements between discrete tumor foci. The clonal evolution of individual prostate cancer foci based on recent studies demonstrates intertumoral heterogeneity with intratumoral homogeneity. The issue of multifocality and interfocal heterogeneity is important and has not been fully elucidated due to lack of the systematic evaluation of ETS rearrangements in multiple tumor sites. The current study investigates the frequency of multiple gene rearrangements within the same focus and between different cancer foci. Fluorescence in situ hybridization (FISH) assays were designed to detect the four most common recurrent ETS gene rearrangements. In a cohort of 88 men with localized prostate cancer, we found ERG, ETV1, and ETV5 rearrangements in 51% (44/86), 6% (5/85), and 1% (1/86), respectively. None of the cases demonstrated ETV4 rearrangements. Mutual exclusiveness of ETS rearrangements was observed in the majority of cases; however, in six cases, we discovered multiple ETS or 50 fusion partner rearrangements within the same tumor focus. In conclusion, we provide further evidence for prostate cancer tumor heterogeneity with the identification of multiple concurrent gene rearrangements. Laboratory Investigation (2011) 91, 404-412; doi: 10.1038/labinvest.2010.179; published online 25 October 2010
Keyword
- ETS (E26 transformation specific) rearrangements
- TMPRSS2-ERG
- heterogeneity
- prostate cancer
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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Svensson, Maria ...
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LaFargue, Christ ...
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MacDonald, There ...
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Pflueger, Doroth ...
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Kitabayashi, Nao ...
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Santa-Cruz, Ashl ...
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show more...
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Garsha, Karl E.
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Sathyanarayana, ...
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Riley, Janice P.
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Yun, Chol S.
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Nagy, Dea
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Kosmeder, Jerry ...
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Pestano, Gary A.
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Tewari, Ashutosh ...
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Demichelis, Fran ...
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Rubin, Mark A.
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Laboratory Inves ...
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Örebro University