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A multi-omics study of circulating phospholipid markers of blood pressure

Liu, Jun (författare)
Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.
de Vries, Paul S. (författare)
Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Texas Hlth Sci Ctr Houston, Dept Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA.
Del Greco, Fabiola M. (författare)
Univ Lubeck, Inst Biomed, Eurac Res, Affiliated Inst, Bolzano, Italy.
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Johansson, Åsa (författare)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
Schraut, Katharina E. (författare)
Univ Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.
Hayward, Caroline (författare)
Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, Med Res Council Human Genet Unit, Edinburgh, Midlothian, Scotland.
van Dijk, Ko Willems (författare)
Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands.;Leiden Univ, Dept Internal Med, Div Endocrinol, Med Ctr, Leiden, Netherlands.
Franco, Oscar H. (författare)
Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Bern, Inst Social & Prevent Med ISPM, Bern, Switzerland.
Hicks, Andrew A. (författare)
Univ Lubeck, Inst Biomed, Eurac Res, Affiliated Inst, Bolzano, Italy.
Vitart, Veronique (författare)
Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, Med Res Council Human Genet Unit, Edinburgh, Midlothian, Scotland.
Rudan, Igor (författare)
Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.
Campbell, Harry (författare)
Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.
Polasek, Ozren (författare)
Univ Split, Sch Med, Dept Publ Hlth, Split, Croatia.;Algebra Univ Coll, Ilica 242, Zagreb, Croatia.
Pramstaller, Peter P. (författare)
Univ Lubeck, Inst Biomed, Eurac Res, Affiliated Inst, Bolzano, Italy.
Wilson, James F. (författare)
Univ Edinburgh, Ctr Global Hlth Res, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, Med Res Council Human Genet Unit, Edinburgh, Midlothian, Scotland.
Gyllensten, Ulf (författare)
Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, Uppsala, Sweden.
van Duijn, Cornelia M. (författare)
Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.
Dehghan, Abbas (författare)
Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London, England.
Demirkan, Ayse (författare)
Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Surrey, Dept Clin & Expt Res, Sect Stat Multiomics, Surrey, England.;Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
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Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England. Erasmus MC, Dept Epidemiol, Univ Med Ctr, Rotterdam, Netherlands.;Univ Texas Hlth Sci Ctr Houston, Dept Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA. (creator_code:org_t)
2022-01-12
2022
Engelska.
Ingår i: Scientific Reports. - : NATURE PORTFOLIO. - 2045-2322. ; 12:1
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • High-throughput techniques allow us to measure a wide-range of phospholipids which can provide insight into the mechanisms of hypertension. We aimed to conduct an in-depth multi-omics study of various phospholipids with systolic blood pressure (SBP) and diastolic blood pressure (DBP). The associations of blood pressure and 151 plasma phospholipids measured by electrospray ionization tandem mass spectrometry were performed by linear regression in five European cohorts (n = 2786 in discovery and n = 1185 in replication). We further explored the blood pressure-related phospholipids in Erasmus Rucphen Family (ERF) study by associating them with multiple cardiometabolic traits (linear regression) and predicting incident hypertension (Cox regression). Mendelian Randomization (MR) and phenome-wide association study (Phewas) were also explored to further investigate these association results. We identified six phosphatidylethanolamines (PE 38:3, PE 38:4, PE 38:6, PE 40:4, PE 40:5 and PE 40:6) and two phosphatidylcholines (PC 32:1 and PC 40:5) which together predicted incident hypertension with an area under the ROC curve (AUC) of 0.61. The identified eight phospholipids are strongly associated with triglycerides, obesity related traits (e.g. waist, waist-hip ratio, total fat percentage, body mass index, lipid-lowering medication, and leptin), diabetes related traits (e.g. glucose, insulin resistance and insulin) and prevalent type 2 diabetes. The genetic determinants of these phospholipids also associated with many lipoproteins, heart rate, pulse rate and blood cell counts. No significant association was identified by bi-directional MR approach. We identified eight blood pressure-related circulating phospholipids that have a predictive value for incident hypertension. Our cross-omics analyses show that phospholipid metabolites in the circulation may yield insight into blood pressure regulation and raise a number of testable hypothesis for future research.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

GENOME-WIDE ASSOCIATIONHIGH-THROUGHPUT; QUANTIFICATION; HYPERTENSION; HERITABILITY TRAIT; SPHOSPHATIDYL; CHOLINE; SPHINGOMYELIN; ADIPONECTIN; METABOLITES

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