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A randomized trial ...
A randomized trial of basing treatment on human papillomavirus and/or cytology results in low-grade cervical lesion triage
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- Bjerre, Pontus (författare)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Department of Obstetrics and Gynecology, Central Hospital, Karlstad, Sweden
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- Silfverdal, Lena (författare)
- Umeå universitet,Obstetrik och gynekologi
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- Dillner, Lena (författare)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Department of Medical Microbiology, Lund University, University Hospital at Malmö, Malmö, Sweden
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- Hagmar, B. (författare)
- Department of Pathology, Norwegian National Hospital, University of Oslo, Oslo, Norway
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- Edvardsson, H. (författare)
- Department of Pathology, Central Hospital, Karlstad, Sweden
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- Dillner, Joakim (författare)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Department of Medical Microbiology, Lund University, University Hospital at Malmö, Malmö, Sweden
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- Andersson-Ellström, Agneta, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Obstetrics and Gynecology, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: American Journal of Obstetrics and Gynecology. - : Elsevier BV. - 1097-6868 .- 0002-9378. ; 199:1
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: This study was undertaken to compare management algorithms that base treatment with loop electrosurgical excision procedure on human papillomavirus and/or repeat Papanicolaou test smear results. STUDY DESIGN: A randomized trial that referred 674 women with either atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions cytology results, detected in organized screening to treatment either (1) if they were positive in a repeat Papanicolaou test smear and/or a human papillomavirus test or (2) if they were positive in the repeat Papanicolaou test smear test only. Women who tested positive were treated, regardless of colposcopic findings. RESULTS: There were 208 of 337 (62%) women who were treated in the human papillomavirus /Papanicolaou test smear group (187/337 because of HPV positivity) and 138 of 337 (41%) in the Papanicolaou test smear only group. Histopathologically diagnosed cervical intraepithelial neoplasia grade 2 or worse was found among 112 of 337 (33.2%) women in the human papillomavirus/Papanicolaou test smear group compared with 85 of 337 (25.2%) women in the Papanicolaou test smear only group (P < .05). Twenty-one women with cervical intraepithelial neoplasia 2+ had normal colposcopy. CONCLUSION: For adequate cervical intraepithelial neoplasia 2+ sensitivity, the decision to use loop electrosurgical excision procedure needs to be based on human papillomavirus testing results and should not exclude women with normal colposcopy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Adult
- Algorithms
- Cervical Intraepithelial Neoplasia/pathology/*surgery/virology
- Cervix Uteri/pathology/surgery/virology
- Colposcopy
- Electrosurgery/methods
- Female
- Humans
- Middle Aged
- Neoplasm Staging
- Papillomaviridae/*isolation & purification
- Treatment Outcome
- Triage
- Uterine Cervical Neoplasms/pathology/*surgery/virology
- *Vaginal Smears
- procedure
- loop electrosurgical excision
- colposcopy
- intraepithelial neoplasia
- atypical squamous cells of undetermined significance
- cervical
- randomized trial
- atypical squamous cells of undetermined significance; cervical intraepithelial neoplasia; colposcopy; loop electrosurgical excision procedure; randomized trial
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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