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Anti-CA15.3 and Ant...
Anti-CA15.3 and Anti-CA125 Antibodies and ovarian cancer risk : Results from the EPIC cohort
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- Cramer, Daniel W. (author)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School,Harvard University
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- Fichorova, Raina N. (author)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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- Terry, Kathryn L. (author)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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- Yamamoto, Hidemi (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Vitonis, Allison F. (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Ardanaz, Eva (author)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Aune, Dagfinn (author)
- Imperial College London
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- Boeing, Heiner (author)
- German Institute of Human Nutrition
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- Brandstedt, Jenny (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
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Boutron-Ruault, Marie Christine (author)
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- Chirlaque, Maria Dolores (author)
- University of Murcia
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Dorronsoro, Miren (author)
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- Dossus, Laure (author)
- International Agency for Research on Cancer, World Health Organization
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- Duell, Eric J. (author)
- Catalan Institute of Oncology
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- Gram, Inger T. (author)
- UiT The Arctic University of Norway, Tromsø
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- Gunter, Marc (author)
- International Agency for Research on Cancer, World Health Organization
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- Hansen, Louise (author)
- Danish Cancer Society
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- Idahl, Annika, 1965- (author)
- Umeå universitet,Umeå University,Obstetrik och gynekologi
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- Johnson, Theron (author)
- German Cancer Research Centre
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- Khaw, Kay Tee (author)
- University of Cambridge
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- Krogh, Vittorio (author)
- Istituto Nazionale dei Tumori
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Kvaskoff, Marina (author)
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- Mattiello, Amalia (author)
- University of Naples Federico II
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- Matullo, Giuseppe (author)
- University of Turin
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- Merritt, Melissa A. (author)
- Imperial College London
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- Nodin, Bjorn (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Orfanos, Philippos (author)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Onland-Moret, N. Charlotte (author)
- University Medical Center Utrecht
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- Palli, Domenico (author)
- Cancer Research and Prevention Institute (ISPO)
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- Peppa, Eleni (author)
- Hellenic Health Foundation, Athens
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- Quiros, J. Ramon (author)
- Public Health Directorate
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Sanchez-Perez, Maria Jose (author)
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Severi, Gianluca (author)
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- Tjønneland, Anne (author)
- Danish Cancer Society
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- Travis, Ruth C. (author)
- University of Oxford
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- Trichopoulou, Antonia (author)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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Tumino, Rosario (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institute,UiT The Arctic University of Norway, Tromsø,Folkhälsan Research Center,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Fortner, Renee T. (author)
- German Cancer Research Centre
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- Kaaks, Rudolf (author)
- German Cancer Research Centre
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(creator_code:org_t)
- American Association for Cancer Research, 2018
- 2018
- English 15 s.
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In: Cancer Epidemiology Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 27:7, s. 790-804
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- Background: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3, and CA125, and generate antibodies against them, but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined. Methods: CA15.3, CA125, and IgG1 antibodies against them were measured in 806 women who developed EOC and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression. Results: In controls, lower antibodies against both mucins were associated with current smoking; and, in postmenopausal women, higher levels with longer oral contraceptive use and later-age-at and shorter-interval-since last birth. Lower anti-CA15.3 antibodies were associated with higher body mass and, in premenopausal women, more ovulatory cycles. Higher anti-CA15.3 and anti-CA125 antibodies were associated with higher risk for mucinous EOC occurring ≥ 3 years from enrollment. Long-term risk for serous EOC was reduced in women with low CA125 and high anti-CA125 antibodies relative to women with low concentrations of both. Conclusions: We found general support for the hypothesis that anti-mucin antibody levels correlate with risk factors for EOC. Antibodies alone or in combinations with their antigen may predict longer term risk of specific EOC types. Impact: Anti-CA125 and anti-CA15.3 antibodies alone or in perspective of antigens may be informative in the pathogenesis of EOC subtypes, but less useful for informing risk for all EOC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Cramer, Daniel W ...
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Fichorova, Raina ...
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Terry, Kathryn L ...
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Yamamoto, Hidemi
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Vitonis, Allison ...
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Ardanaz, Eva
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show more...
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Aune, Dagfinn
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Boeing, Heiner
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Brandstedt, Jenn ...
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Boutron-Ruault, ...
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Chirlaque, Maria ...
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Dorronsoro, Mire ...
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Dossus, Laure
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Duell, Eric J.
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Gram, Inger T.
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Gunter, Marc
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Hansen, Louise
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Idahl, Annika, 1 ...
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Johnson, Theron
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Khaw, Kay Tee
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Krogh, Vittorio
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Kvaskoff, Marina
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Mattiello, Amali ...
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Matullo, Giusepp ...
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Merritt, Melissa ...
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Nodin, Bjorn
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Orfanos, Philipp ...
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Onland-Moret, N. ...
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Palli, Domenico
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Peppa, Eleni
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Quiros, J. Ramon
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Sanchez-Perez, M ...
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Severi, Gianluca
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Tjønneland, Anne
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Travis, Ruth C.
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Trichopoulou, An ...
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Tumino, Rosario
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Weiderpass, Elis ...
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Fortner, Renee T ...
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Kaaks, Rudolf
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Lund University
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Umeå University
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Karolinska Institutet